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The map label for this gene is lytC [H]

Identifier: 226949499

GI number: 226949499

Start: 2514477

End: 2516093

Strand: Reverse

Name: lytC [H]

Synonym: CLM_2434

Alternate gene names: 226949499

Gene position: 2516093-2514477 (Counterclockwise)

Preceding gene: 226949500

Following gene: 226949497

Centisome position: 60.55

GC content: 26.84

Gene sequence:

>1617_bases
ATGAAAAGGATAATTACATTAGTTACTTCTATAGCATTAATTTTGGGAGTATCGACAATAGCTCAGGGAAAAAATAATTA
CAGTGTAAGTAGAATAGAGGGTGCAAATAGATATAAGACATCTTTAAACATATCAAAACAATTTAATAATGATAAAGTAG
ATAATGTAATAATAGCAAGTGGAAGTGATTTTCCAGATGCATTAGCGGGAAGTAGTCTTTCTAAAAAATTAAAAACTCCA
ATATTATTGGTAGATAAAGATATAAAAGGCAGCTTAGATTCAATAGATTATATAAAGAGTCATTTAAATGTAAATGGAAA
TGTATACATATTAGGTGGTAATGCTTCTGTAAGTGAAAATTATATAAATTACATAAAATCCTTAGGATATAAAAATATTA
TAAGATTAGATGGAAAAAATAGATTTGATACAAATAGAGCAATAATAAATTCCATGAATATAAAAAAGGGAACTCCAATA
GTTATAACTAATGGATATGGATTTGCAGATGCATTAAGTGTATCTAGTGCTGCAGCCTCAAAAGGATATCCTATTTTAAT
GAGTGATTCTAAAACTTTGCCTAATGAAATTAAAGATAAAATTAGAGAAATTCAACCTTCTAAATTATATTTAATAGGTG
GACAAGGTTCTTTAAGTAATAATATAATTACAGAAGTAAGAAATATAGTACCTTCATTAAATTATAGCAATATAACAAGA
ATTTCGGGAAATAGCAGATATGATACTTCATTAGAGATATGTAAACACTTCAACTTAGACTCAGATATAGCAGTAATTGC
TAATGGAGAGAATTTTCCAGATGCCTTATCTGGCAGCGCATTAGCAGCAAAACAAAATGCTCCAATAGTACTTACAAATG
GTAAAGATATGTCAAATCAGAAAAAATATTTAAATACAACAAACTATAAAAATTTAATTTTACTTGGTGGTTCGGGAGCA
ATAAGCTCTAATTTAGAAAATATCTTAAATGGAACAATAAATGAACTAGATATAATAAAGAGTAAAAGTGTTTATAACTC
TAATATGAAAGATAACAATGGAGACATTTATTCAGTGTACCTATATAGTGATGACAAAAAAATAGAAATAGCAGAGTATA
GCTGGGCTGGAGCACAAAAAGGAGATATATTAAGTACTGGTCATTATAAAATAGCTATAGTAAAGCAAGGAGAGAGTGAG
CCAGAGATATATGATGCATATGATAATAAACCAATAAAATTAAACTTAAACAGAAATTCAGTTAAAGTATATAAAAATAA
ACAATCAAATGGTTCAGATTTTCTTATGATTGGTATGCCAGTATCCAGTAATATTTCAGAAATAAAGCTTTATTATATAA
AAGATGGAGAAATTAAAAAAACATATTTTAAAGATAAAAAAAGTATGGAAAGTAGGGCATATACTTTTAATTCACTATTC
TTTAATCAAAGAGAGGCTGATATTTTTGAAACATCAACTTATGACAATATGCAGACTTTTTTATTCTATGTACATTCATG
GAAATTCAATTTAGAGGATGGTGTCTTCTATAATTTAGGATTTAGGACTATGAATCAAGATACTTATTTTAATTACGAAA
AAAAGGTTCAACAATAA

Upstream 100 bases:

>100_bases
TATATAATATGCATTATTTGTTGTTTTATATAAATTGAATTTTGTTTTTAAATCTTAAAAAATAGTAGTATTAGTAACAA
TTAGGAAGGAGAGACATTCA

Downstream 100 bases:

>100_bases
TTAAATTATAACTTGTATATAAATATTTAATATTATAAAATACGCTAAATATTTGTTATAATATCAGGAGATTAATGAAT
ACGGATATTAATTAAATTTT

Product: amidase domain-containing protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MKRIITLVTSIALILGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIASGSDFPDALAGSSLSKKLKTP
ILLVDKDIKGSLDSIDYIKSHLNVNGNVYILGGNASVSENYINYIKSLGYKNIIRLDGKNRFDTNRAIINSMNIKKGTPI
VITNGYGFADALSVSSAAASKGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
ISGNSRYDTSLEICKHFNLDSDIAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQKKYLNTTNYKNLILLGGSGA
ISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSVYLYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESE
PEIYDAYDNKPIKLNLNRNSVKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEIKKTYFKDKKSMESRAYTFNSLF
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFRTMNQDTYFNYEKKVQQ

Sequences:

>Translated_538_residues
MKRIITLVTSIALILGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIASGSDFPDALAGSSLSKKLKTP
ILLVDKDIKGSLDSIDYIKSHLNVNGNVYILGGNASVSENYINYIKSLGYKNIIRLDGKNRFDTNRAIINSMNIKKGTPI
VITNGYGFADALSVSSAAASKGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
ISGNSRYDTSLEICKHFNLDSDIAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQKKYLNTTNYKNLILLGGSGA
ISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSVYLYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESE
PEIYDAYDNKPIKLNLNRNSVKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEIKKTYFKDKKSMESRAYTFNSLF
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFRTMNQDTYFNYEKKVQQ
>Mature_538_residues
MKRIITLVTSIALILGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIASGSDFPDALAGSSLSKKLKTP
ILLVDKDIKGSLDSIDYIKSHLNVNGNVYILGGNASVSENYINYIKSLGYKNIIRLDGKNRFDTNRAIINSMNIKKGTPI
VITNGYGFADALSVSSAAASKGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
ISGNSRYDTSLEICKHFNLDSDIAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQKKYLNTTNYKNLILLGGSGA
ISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSVYLYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESE
PEIYDAYDNKPIKLNLNRNSVKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEIKKTYFKDKKSMESRAYTFNSLF
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFRTMNQDTYFNYEKKVQQ

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 60010; Mature: 60010

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIITLVTSIALILGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIAS
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEC
GSDFPDALAGSSLSKKLKTPILLVDKDIKGSLDSIDYIKSHLNVNGNVYILGGNASVSEN
CCCCCHHHCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHH
YINYIKSLGYKNIIRLDGKNRFDTNRAIINSMNIKKGTPIVITNGYGFADALSVSSAAAS
HHHHHHHCCCCEEEEECCCCCCCCCHHEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHC
KGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
CCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEE
ISGNSRYDTSLEICKHFNLDSDIAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQ
ECCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCCCCCC
KKYLNTTNYKNLILLGGSGAISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSVY
HHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHEEECCCHHCCCCCCCCCCEEEEE
LYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESEPEIYDAYDNKPIKLNLNRNS
EECCCCEEEEEEEECCCCCCCCEEECCCEEEEEEECCCCCCCEEECCCCCCEEEEECCCE
VKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEIKKTYFKDKKSMESRAYTFNSLF
EEEEECCCCCCCCEEEEEECCCCCCCEEEEEEEECCCEEEHHHHHHHHHHHHCEEEEHHE
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFRTMNQDTYFNYEKKVQQ
ECCCCCCEEECCCCCCCEEEEEEEEEEEEECCCCEEEEECEEEECCCCEECHHHHHCC
>Mature Secondary Structure
MKRIITLVTSIALILGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIAS
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEC
GSDFPDALAGSSLSKKLKTPILLVDKDIKGSLDSIDYIKSHLNVNGNVYILGGNASVSEN
CCCCCHHHCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHH
YINYIKSLGYKNIIRLDGKNRFDTNRAIINSMNIKKGTPIVITNGYGFADALSVSSAAAS
HHHHHHHCCCCEEEEECCCCCCCCCHHEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHC
KGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
CCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEE
ISGNSRYDTSLEICKHFNLDSDIAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQ
ECCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCCCCCC
KKYLNTTNYKNLILLGGSGAISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSVY
HHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHEEECCCHHCCCCCCCCCCEEEEE
LYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESEPEIYDAYDNKPIKLNLNRNS
EECCCCEEEEEEEECCCCCCCCEEECCCEEEEEEECCCCCCCEEECCCCCCEEEEECCCE
VKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEIKKTYFKDKKSMESRAYTFNSLF
EEEEECCCCCCCCEEEEEECCCCCCCEEEEEEEECCCEEEHHHHHHHHHHHHCEEEEHHE
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFRTMNQDTYFNYEKKVQQ
ECCCCCCEEECCCCCCCEEEEEEEEEEEEECCCCEEEEECEEEECCCCEECHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]