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The map label for this gene is bdhA [H]

Identifier: 226949485

GI number: 226949485

Start: 2503187

End: 2504260

Strand: Reverse

Name: bdhA [H]

Synonym: CLM_2420

Alternate gene names: 226949485

Gene position: 2504260-2503187 (Counterclockwise)

Preceding gene: 226949486

Following gene: 226949482

Centisome position: 60.27

GC content: 34.26

Gene sequence:

>1074_bases
ATGAAAGCAGCATTATGGTATGAAAAAAAAGATGTAAGAGTGGAAGAAATTGAAGAACCAAAGGTAGTAGAAGGATATGT
AAAAATTAAAGTAAAATGGTGTGGAATATGTGGTTCCGATTTACATGAATATTTAGGAGGCCCTATATTTATTCCAGTAG
GACAACCTCATGCGTTAAGTGGAACAACAGCACCAGTAGTTTTAGGACACGAATTTTCAGGAGAAATAGTAGAATTAGGA
CAAGGTGTAACAAAATTTAATATTGGAGATAGGGTAATTGTTGAACCTATAGTAGCTTGTGGAAAATGTCCAGCCTGTAT
GGAAGGGAAATATAATCTTTGTTCATCTTTAGGTTTTCATGGACTTTGTGGAAGTGGCGGTGGACTTGCAGAATATACTG
TATTTCCAGAGGAATTTGTTCATAAAATTCCAGATGAAATGTCCTATGAGGATGCGGCTTTAGTAGAACCAATGGCAGTA
GCACTTCATTCTGTAAGAATAGCTAATTTTAATACAGGAGATACAGCTTTAGTATTAGGTGCAGGACCAATAGGTCTTGC
CACAATAGAATGCTTAAAAGCAGCTGGAGCAAGACTCATAGTAGTTTTACAAAGAAAATCTATAAGACAAAAATATGCAA
AAAGAGCAGGGGCAGATGTAGTTTTAGATCCTAATGAAGTTAATATACCAGAAGAAGTTAAAAAACTTACAGATGGGTTA
GGTGTAGATGTAGCCTTTGAAACCACAGGAGCTAAGATAGGATTTGATACTGGTATTGAAAGCTTAAAATTTGAAGGTAC
AATGGTTATAACTAGTATATGGGAAAAGGATACAAGCTTTAATCCGAATGTATTAGTATTTACTGAAAAGAAAATTGTAG
GAACTTTAGCATATAGACATGAATTCCCAGCCACTATGGCGTTAATGAAGGATGGAAGAATAAAAACAGATGGATATATT
ACAAAGAAAATAGCTTTAGATGATATAGTAGAAGAAGGATTTGGGGCTTTAACTGGACCGGAAAAGAAAAAACATGTAAA
AATTATTGTAACTCCAGATAAATCACTTTTATAA

Upstream 100 bases:

>100_bases
CTATAAATTTAGGGTAATTAAAGCTTTGGCATTATAATTGCTTTAAATAATGTTAATTAATTAACAACTATGTTAAAATT
AAAACTCTAGGAGGGCTATT

Downstream 100 bases:

>100_bases
ATTAATTATTTTTAGATCACATATTTAACCTACTAAAATTTGTTTATAGTAGGTTAAATATTTTTGAGAATCAATGTTTA
ACATTTTTATTTATCAATTC

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKAALWYEKKDVRVEEIEEPKVVEGYVKIKVKWCGICGSDLHEYLGGPIFIPVGQPHALSGTTAPVVLGHEFSGEIVELG
QGVTKFNIGDRVIVEPIVACGKCPACMEGKYNLCSSLGFHGLCGSGGGLAEYTVFPEEFVHKIPDEMSYEDAALVEPMAV
ALHSVRIANFNTGDTALVLGAGPIGLATIECLKAAGARLIVVLQRKSIRQKYAKRAGADVVLDPNEVNIPEEVKKLTDGL
GVDVAFETTGAKIGFDTGIESLKFEGTMVITSIWEKDTSFNPNVLVFTEKKIVGTLAYRHEFPATMALMKDGRIKTDGYI
TKKIALDDIVEEGFGALTGPEKKKHVKIIVTPDKSLL

Sequences:

>Translated_357_residues
MKAALWYEKKDVRVEEIEEPKVVEGYVKIKVKWCGICGSDLHEYLGGPIFIPVGQPHALSGTTAPVVLGHEFSGEIVELG
QGVTKFNIGDRVIVEPIVACGKCPACMEGKYNLCSSLGFHGLCGSGGGLAEYTVFPEEFVHKIPDEMSYEDAALVEPMAV
ALHSVRIANFNTGDTALVLGAGPIGLATIECLKAAGARLIVVLQRKSIRQKYAKRAGADVVLDPNEVNIPEEVKKLTDGL
GVDVAFETTGAKIGFDTGIESLKFEGTMVITSIWEKDTSFNPNVLVFTEKKIVGTLAYRHEFPATMALMKDGRIKTDGYI
TKKIALDDIVEEGFGALTGPEKKKHVKIIVTPDKSLL
>Mature_357_residues
MKAALWYEKKDVRVEEIEEPKVVEGYVKIKVKWCGICGSDLHEYLGGPIFIPVGQPHALSGTTAPVVLGHEFSGEIVELG
QGVTKFNIGDRVIVEPIVACGKCPACMEGKYNLCSSLGFHGLCGSGGGLAEYTVFPEEFVHKIPDEMSYEDAALVEPMAV
ALHSVRIANFNTGDTALVLGAGPIGLATIECLKAAGARLIVVLQRKSIRQKYAKRAGADVVLDPNEVNIPEEVKKLTDGL
GVDVAFETTGAKIGFDTGIESLKFEGTMVITSIWEKDTSFNPNVLVFTEKKIVGTLAYRHEFPATMALMKDGRIKTDGYI
TKKIALDDIVEEGFGALTGPEKKKHVKIIVTPDKSLL

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=325, Percent_Identity=30.4615384615385, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=30.9973045822102, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4501933, Length=385, Percent_Identity=30.1298701298701, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI34577061, Length=385, Percent_Identity=29.0909090909091, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI262073058, Length=378, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71743840, Length=378, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=26.1707988980716, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=26.1707988980716, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI71565154, Length=275, Percent_Identity=31.2727272727273, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI71565152, Length=367, Percent_Identity=26.7029972752044, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788073, Length=320, Percent_Identity=35, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787863, Length=232, Percent_Identity=35.7758620689655, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=29.4294294294294, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790045, Length=338, Percent_Identity=29.8816568047337, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788075, Length=354, Percent_Identity=29.0960451977401, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788407, Length=297, Percent_Identity=29.6296296296296, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786825, Length=299, Percent_Identity=29.4314381270903, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790718, Length=309, Percent_Identity=26.8608414239482, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082125, Length=308, Percent_Identity=30.1948051948052, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1786552, Length=354, Percent_Identity=27.4011299435028, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=23.9747634069401, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787572, Length=231, Percent_Identity=26.8398268398268, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786518, Length=295, Percent_Identity=27.1186440677966, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=337, Percent_Identity=31.4540059347181, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=266, Percent_Identity=33.8345864661654, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71997431, Length=284, Percent_Identity=29.5774647887324, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=284, Percent_Identity=29.5774647887324, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=278, Percent_Identity=26.6187050359712, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=325, Percent_Identity=24.3076923076923, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=220, Percent_Identity=30.4545454545455, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=311, Percent_Identity=25.4019292604502, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=383, Percent_Identity=36.5535248041775, Blast_Score=239, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319258, Length=381, Percent_Identity=36.745406824147, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322619, Length=326, Percent_Identity=33.1288343558282, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319955, Length=326, Percent_Identity=33.1288343558282, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323099, Length=326, Percent_Identity=31.2883435582822, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6320033, Length=365, Percent_Identity=28.7671232876712, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17137530, Length=323, Percent_Identity=30.9597523219814, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17737897, Length=333, Percent_Identity=29.7297297297297, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI45550770, Length=331, Percent_Identity=24.773413897281, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45551930, Length=331, Percent_Identity=24.773413897281, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI221457811, Length=331, Percent_Identity=24.773413897281, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17737895, Length=303, Percent_Identity=30.6930693069307, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 38581; Mature: 38581

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAALWYEKKDVRVEEIEEPKVVEGYVKIKVKWCGICGSDLHEYLGGPIFIPVGQPHALS
CCCCEEECCCCCCHHHCCCCCEEEEEEEEEEEEECCCCHHHHHHCCCCEEEECCCCCCCC
GTTAPVVLGHEFSGEIVELGQGVTKFNIGDRVIVEPIVACGKCPACMEGKYNLCSSLGFH
CCCCEEEEECCCCCCHHHHCCCCEEECCCCCHHHHHHHHCCCCCHHCCCCHHHHHHCCCC
GLCGSGGGLAEYTVFPEEFVHKIPDEMSYEDAALVEPMAVALHSVRIANFNTGDTALVLG
CCCCCCCCCEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEEE
AGPIGLATIECLKAAGARLIVVLQRKSIRQKYAKRAGADVVLDPNEVNIPEEVKKLTDGL
CCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCC
GVDVAFETTGAKIGFDTGIESLKFEGTMVITSIWEKDTSFNPNVLVFTEKKIVGTLAYRH
CEEEEEECCCCEEECCCCCCCEEECCEEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHH
EFPATMALMKDGRIKTDGYITKKIALDDIVEEGFGALTGPEKKKHVKIIVTPDKSLL
CCCHHHHHHCCCCEECCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MKAALWYEKKDVRVEEIEEPKVVEGYVKIKVKWCGICGSDLHEYLGGPIFIPVGQPHALS
CCCCEEECCCCCCHHHCCCCCEEEEEEEEEEEEECCCCHHHHHHCCCCEEEECCCCCCCC
GTTAPVVLGHEFSGEIVELGQGVTKFNIGDRVIVEPIVACGKCPACMEGKYNLCSSLGFH
CCCCEEEEECCCCCCHHHHCCCCEEECCCCCHHHHHHHHCCCCCHHCCCCHHHHHHCCCC
GLCGSGGGLAEYTVFPEEFVHKIPDEMSYEDAALVEPMAVALHSVRIANFNTGDTALVLG
CCCCCCCCCEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEEE
AGPIGLATIECLKAAGARLIVVLQRKSIRQKYAKRAGADVVLDPNEVNIPEEVKKLTDGL
CCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCC
GVDVAFETTGAKIGFDTGIESLKFEGTMVITSIWEKDTSFNPNVLVFTEKKIVGTLAYRH
CEEEEEECCCCEEECCCCCCCEEECCEEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHH
EFPATMALMKDGRIKTDGYITKKIALDDIVEEGFGALTGPEKKKHVKIIVTPDKSLL
CCCHHHHHHCCCCEECCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]