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The map label for this gene is hgdC_1 [H]

Identifier: 226949460

GI number: 226949460

Start: 2469949

End: 2470722

Strand: Reverse

Name: hgdC_1 [H]

Synonym: CLM_2393

Alternate gene names: 226949460

Gene position: 2470722-2469949 (Counterclockwise)

Preceding gene: 226949461

Following gene: 226949459

Centisome position: 59.46

GC content: 34.24

Gene sequence:

>774_bases
ATGTATACAATGGGATTGGATATAGGTTCTACTACCTCTAAGGGTGTTATTATAAAGGATGGAGAGGAAATAGTTGCTAG
TGTTTTAGTACCTGTTGGAACTGGAACCAGTGGACCTCTAAAATTAATAAAAGAATTAAAAGAAAAATCTAATTTAACAG
AAAAGGACATAGAAAAAACCGTAGTTACAGGCTATGGTAGAATCCAATATAAAGATGCTGACAAACAAATAAGTGAATTA
AGTTGCCATGCTAAAGGGGTGGCATTTTTAATACCAGGTGCAAGGACTATAATAGATATTGGTGGACAAGATGCTAAGGC
TATGAAGTTGAATAATAAGGGTAAACTTATAAATTTTATAATGAATGATAAGTGTGCCGCTGGTACAGGAAGATTTTTAG
ATGTTATGGCAGGAGTTCTTGAAACGGATGTTTCTAAATTAGGAGAAATATCAGAAAAATCTACAAAGGAAGTTTCAATT
AGTAGTACCTGTACTGTGTTTGCTGAATCAGAGGTAATTTCTCATCTATCAGCAAATGCAAAAAAAGAAGATATTGTAGC
AGGAATTCATACCTCTGTAGTAAGACGTGTATCAACTCTTGCCATGAGAGTAGGTATTGAAGATCAAGTAGTTATGGTAG
GTGGAGTAGCTAGAAATAAAGGAATAGTTAAAGCTATGGAAAAGGAACTAGGCCATGATATAAAAGTACCAAAATTAGCA
CAATTAACTGGAGCATTAGGCGCAGCTATATATGCTTTTGAGGAAACAAAATAG

Upstream 100 bases:

>100_bases
AAGGAAGATGAGGACAATATATAAAAAAAGATGGTATATCAACTGTAGAGTCTGAATAACAATTATTATACTAAAATATT
TTAAAAAGGGGGATACACAT

Downstream 100 bases:

>100_bases
ATTTAATTGAGAGGGCAAAGATAAAAAGTTCATTTTATGTACTTTTTATCTTTGCTATATTAAAATTAAATATGTTTTTA
CAGAGACCTTTAAAATATTA

Product: 2-hydroxyglutaryl-CoA dehydratase subunit A

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MYTMGLDIGSTTSKGVIIKDGEEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKTVVTGYGRIQYKDADKQISEL
SCHAKGVAFLIPGARTIIDIGGQDAKAMKLNNKGKLINFIMNDKCAAGTGRFLDVMAGVLETDVSKLGEISEKSTKEVSI
SSTCTVFAESEVISHLSANAKKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPKLA
QLTGALGAAIYAFEETK

Sequences:

>Translated_257_residues
MYTMGLDIGSTTSKGVIIKDGEEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKTVVTGYGRIQYKDADKQISEL
SCHAKGVAFLIPGARTIIDIGGQDAKAMKLNNKGKLINFIMNDKCAAGTGRFLDVMAGVLETDVSKLGEISEKSTKEVSI
SSTCTVFAESEVISHLSANAKKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPKLA
QLTGALGAAIYAFEETK
>Mature_257_residues
MYTMGLDIGSTTSKGVIIKDGEEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKTVVTGYGRIQYKDADKQISEL
SCHAKGVAFLIPGARTIIDIGGQDAKAMKLNNKGKLINFIMNDKCAAGTGRFLDVMAGVLETDVSKLGEISEKSTKEVSI
SSTCTVFAESEVISHLSANAKKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPKLA
QLTGALGAAIYAFEETK

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=252, Percent_Identity=40.8730158730159, Blast_Score=192, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 27311; Mature: 27311

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTMGLDIGSTTSKGVIIKDGEEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKT
CEEEEECCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
VVTGYGRIQYKDADKQISELSCHAKGVAFLIPGARTIIDIGGQDAKAMKLNNKGKLINFI
HHCCCCEEEEECHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCEEEEECCCCCEEEEE
MNDKCAAGTGRFLDVMAGVLETDVSKLGEISEKSTKEVSISSTCTVFAESEVISHLSANA
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEEHHHHHHHHHCCC
KKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPKLA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHH
QLTGALGAAIYAFEETK
HHHHHHHHHEEEEECCC
>Mature Secondary Structure
MYTMGLDIGSTTSKGVIIKDGEEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKT
CEEEEECCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
VVTGYGRIQYKDADKQISELSCHAKGVAFLIPGARTIIDIGGQDAKAMKLNNKGKLINFI
HHCCCCEEEEECHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCEEEEECCCCCEEEEE
MNDKCAAGTGRFLDVMAGVLETDVSKLGEISEKSTKEVSISSTCTVFAESEVISHLSANA
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEEHHHHHHHHHCCC
KKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPKLA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHH
QLTGALGAAIYAFEETK
HHHHHHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]