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The map label for this gene is pepD [H]

Identifier: 226948666

GI number: 226948666

Start: 1621000

End: 1622463

Strand: Direct

Name: pepD [H]

Synonym: CLM_1562

Alternate gene names: 226948666

Gene position: 1621000-1622463 (Clockwise)

Preceding gene: 226948662

Following gene: 226948667

Centisome position: 39.01

GC content: 26.23

Gene sequence:

>1464_bases
ATGTACAAAAGAATAGATGATTTACTTTGCAATAAAGTTTTTAAATATTTTAAAGATATAAGTAATGTACCTAGAGAATC
AGGATATGAAAAGAAAGTTAGTGACTATCTCTTTAATTTTGCAAAAGAAAAAAATTTATGGGTTATTCAAGATGAATATT
TAAATATAATTATAAAAAAGAAAGCTACAAAGGGATATGAAAAAGCACCTACTATTATATTTCAGGCACATATGGACATG
GTTTGTGAAAAGGCTAATGAAAAAGTACATGATTTTAAAAATGATCCTATAGAATTTAAAATAGAAGGGGATATGCTTTA
TGCAAAGGATACAACTTTAGGAGCTGATGATGGAATTGGATTAGCTTATATGTTAGCTATATTAGATTCTAATGATATTA
ATCATCCTAATCTTGAAATGTTATTTACCACTGAAGAAGAAACTACTATGCTAGGAGCGTTAAATGTTGACCATAATTTG
TTTGAAGGTAGAATTCTTATAAATATAGACTCAGAAGAGGAAGGGAAAATTTTAGTAAGCAGTGCTGGAGGAGTAGATAT
TAAACATAATGTACCTCTAAAATGGGAAAACACAAAAAAAAATTTAGAAGTTTTTAATATAGTAGTAGAAGATTTAAAAG
GGGGACATTCAGGACTTGATATCCATAAAGGAAGAGGAAATGCTATTAAAATATTAGGAAGAATACTAAAGAATCTAAAC
TATAATATGGAATATTCTTTAGCTTTTATAAAGGGTGGAAGCAAAACTAATAATATTCCTGTAAATGCTGAGGCTAAAAT
TTTAATAGAAAAAAGTTATGAAAATAAATTAAAGGAATTTATAAAATTTTCGAATAATACATTAAAAGAGGAGCTATATC
TAAAAGATGATAATATAAACATAAAGTTAAAAGATTCTACTCATAATACAGATAAAATTATTTCAGAGAAAAGCAAAAAT
TTAATTTTAAATTCTATATTGATTACTCCAAATGGTATAGAATCTATGGTAACTAATATAGATAGATTAGTAGAAAGTTC
TGTAAATTTAGGAACTATTTCAGTAGATGATAGTAAAGCTATATTGGAAAGTGGAATTAGAAGTTCAAACAAGAATTTAA
AGCATAAAATAATAGAAAAGATAAAGGCATTAGGGGAGATTACAAATTCACAAGTTATTTGTCATGGAGATTATCCAGAA
TGGTCATATGATGAAAAATCAGAAGTACTTTCTCTAAGTAGAAAAGTGTTTAAAAAATTATATGGGAAAGAAGCAGAAAT
TATAGCATATCATTGTGGTATTGAATGTGGGGTGCTTAAAAATAAAATAGAAGGATTACAGTGCATATCTATAGGTCCTA
ATATTTTTGAAATACATACACCTAAAGAACACTTAAGTATAAGTTCTGCAGAAAGAACTTTTCAATACATATTAGAAATA
TTAAAGGAAATGAATAATTTTTAG

Upstream 100 bases:

>100_bases
GTTAATGTGTGATATTATTTTTGAAATTTTACTTTTTTATGCTATTACTTTTATATTATAATAAACTTAGAGAAAATTTA
TATGAAGGTAGGAGAATTAT

Downstream 100 bases:

>100_bases
TTACAAGATTATAAAAAGATGTCACAGAATTGTATGTATGGAAGGGAGAGTGCTGCCATGAACAAATCTAAAAAAAATAT
TATAATAGGTGCTACTATAT

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MYKRIDDLLCNKVFKYFKDISNVPRESGYEKKVSDYLFNFAKEKNLWVIQDEYLNIIIKKKATKGYEKAPTIIFQAHMDM
VCEKANEKVHDFKNDPIEFKIEGDMLYAKDTTLGADDGIGLAYMLAILDSNDINHPNLEMLFTTEEETTMLGALNVDHNL
FEGRILINIDSEEEGKILVSSAGGVDIKHNVPLKWENTKKNLEVFNIVVEDLKGGHSGLDIHKGRGNAIKILGRILKNLN
YNMEYSLAFIKGGSKTNNIPVNAEAKILIEKSYENKLKEFIKFSNNTLKEELYLKDDNINIKLKDSTHNTDKIISEKSKN
LILNSILITPNGIESMVTNIDRLVESSVNLGTISVDDSKAILESGIRSSNKNLKHKIIEKIKALGEITNSQVICHGDYPE
WSYDEKSEVLSLSRKVFKKLYGKEAEIIAYHCGIECGVLKNKIEGLQCISIGPNIFEIHTPKEHLSISSAERTFQYILEI
LKEMNNF

Sequences:

>Translated_487_residues
MYKRIDDLLCNKVFKYFKDISNVPRESGYEKKVSDYLFNFAKEKNLWVIQDEYLNIIIKKKATKGYEKAPTIIFQAHMDM
VCEKANEKVHDFKNDPIEFKIEGDMLYAKDTTLGADDGIGLAYMLAILDSNDINHPNLEMLFTTEEETTMLGALNVDHNL
FEGRILINIDSEEEGKILVSSAGGVDIKHNVPLKWENTKKNLEVFNIVVEDLKGGHSGLDIHKGRGNAIKILGRILKNLN
YNMEYSLAFIKGGSKTNNIPVNAEAKILIEKSYENKLKEFIKFSNNTLKEELYLKDDNINIKLKDSTHNTDKIISEKSKN
LILNSILITPNGIESMVTNIDRLVESSVNLGTISVDDSKAILESGIRSSNKNLKHKIIEKIKALGEITNSQVICHGDYPE
WSYDEKSEVLSLSRKVFKKLYGKEAEIIAYHCGIECGVLKNKIEGLQCISIGPNIFEIHTPKEHLSISSAERTFQYILEI
LKEMNNF
>Mature_487_residues
MYKRIDDLLCNKVFKYFKDISNVPRESGYEKKVSDYLFNFAKEKNLWVIQDEYLNIIIKKKATKGYEKAPTIIFQAHMDM
VCEKANEKVHDFKNDPIEFKIEGDMLYAKDTTLGADDGIGLAYMLAILDSNDINHPNLEMLFTTEEETTMLGALNVDHNL
FEGRILINIDSEEEGKILVSSAGGVDIKHNVPLKWENTKKNLEVFNIVVEDLKGGHSGLDIHKGRGNAIKILGRILKNLN
YNMEYSLAFIKGGSKTNNIPVNAEAKILIEKSYENKLKEFIKFSNNTLKEELYLKDDNINIKLKDSTHNTDKIISEKSKN
LILNSILITPNGIESMVTNIDRLVESSVNLGTISVDDSKAILESGIRSSNKNLKHKIIEKIKALGEITNSQVICHGDYPE
WSYDEKSEVLSLSRKVFKKLYGKEAEIIAYHCGIECGVLKNKIEGLQCISIGPNIFEIHTPKEHLSISSAERTFQYILEI
LKEMNNF

Specific function: Dipeptidase with broad substrate specificity [H]

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=480, Percent_Identity=35.625, Blast_Score=309, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 55294; Mature: 55294

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKRIDDLLCNKVFKYFKDISNVPRESGYEKKVSDYLFNFAKEKNLWVIQDEYLNIIIKK
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHEEEEEEE
KATKGYEKAPTIIFQAHMDMVCEKANEKVHDFKNDPIEFKIEGDMLYAKDTTLGADDGIG
CCCCCCCCCCEEEEEHHHHHHHHHHCHHHHHCCCCCEEEEECCCEEEEECCCCCCCCCCC
LAYMLAILDSNDINHPNLEMLFTTEEETTMLGALNVDHNLFEGRILINIDSEEEGKILVS
HHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEECCEEEEEECCCCCCCEEEE
SAGGVDIKHNVPLKWENTKKNLEVFNIVVEDLKGGHSGLDIHKGRGNAIKILGRILKNLN
ECCCEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCC
YNMEYSLAFIKGGSKTNNIPVNAEAKILIEKSYENKLKEFIKFSNNTLKEELYLKDDNIN
CCEEEEEEEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEEEECCCEE
IKLKDSTHNTDKIISEKSKNLILNSILITPNGIESMVTNIDRLVESSVNLGTISVDDSKA
EEEECCCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCHHH
ILESGIRSSNKNLKHKIIEKIKALGEITNSQVICHGDYPEWSYDEKSEVLSLSRKVFKKL
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
YGKEAEIIAYHCGIECGVLKNKIEGLQCISIGPNIFEIHTPKEHLSISSAERTFQYILEI
HCCCCEEEEEECCCEEHHHHHHCCCEEEEEECCCEEEECCCHHHCCCCHHHHHHHHHHHH
LKEMNNF
HHHHHCC
>Mature Secondary Structure
MYKRIDDLLCNKVFKYFKDISNVPRESGYEKKVSDYLFNFAKEKNLWVIQDEYLNIIIKK
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHEEEEEEE
KATKGYEKAPTIIFQAHMDMVCEKANEKVHDFKNDPIEFKIEGDMLYAKDTTLGADDGIG
CCCCCCCCCCEEEEEHHHHHHHHHHCHHHHHCCCCCEEEEECCCEEEEECCCCCCCCCCC
LAYMLAILDSNDINHPNLEMLFTTEEETTMLGALNVDHNLFEGRILINIDSEEEGKILVS
HHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEECCEEEEEECCCCCCCEEEE
SAGGVDIKHNVPLKWENTKKNLEVFNIVVEDLKGGHSGLDIHKGRGNAIKILGRILKNLN
ECCCEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCC
YNMEYSLAFIKGGSKTNNIPVNAEAKILIEKSYENKLKEFIKFSNNTLKEELYLKDDNIN
CCEEEEEEEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEEEECCCEE
IKLKDSTHNTDKIISEKSKNLILNSILITPNGIESMVTNIDRLVESSVNLGTISVDDSKA
EEEECCCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCHHH
ILESGIRSSNKNLKHKIIEKIKALGEITNSQVICHGDYPEWSYDEKSEVLSLSRKVFKKL
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
YGKEAEIIAYHCGIECGVLKNKIEGLQCISIGPNIFEIHTPKEHLSISSAERTFQYILEI
HCCCCEEEEEECCCEEHHHHHHCCCEEEEEECCCEEEECCCHHHCCCCHHHHHHHHHHHH
LKEMNNF
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]