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The map label for this gene is rnz [H]

Identifier: 226948654

GI number: 226948654

Start: 1608979

End: 1610016

Strand: Direct

Name: rnz [H]

Synonym: CLM_1549

Alternate gene names: 226948654

Gene position: 1608979-1610016 (Clockwise)

Preceding gene: 226948653

Following gene: 226948655

Centisome position: 38.72

GC content: 30.92

Gene sequence:

>1038_bases
TTGGATTTGGCTTTATTAGGATGTGGAGGAGGCATGCCTATTCCAGATAGGTTCTTATCTTCCCTTCTTATGAATTATAG
AGGGAGAAAAATACTTATAGATTGTGGAGAAGGAACTCAAGTATCTATGAAAATACTAGGGTGGGGCTTTAAGTCTATTG
ATATTATATGTATAACTCATATGCATGGAGATCATGTAGTTGGGCTACCAGGGCTCTTGGCTACTATAGGTAATAGTGGC
AGAGAAGATCCCTTAACTATAATAGGTCCAGAAGGCATAGAAAATGTAATAACTGGACTTAGAACTATAGTTCCCTATTT
ACCTTATGATATAGTTATAATAGAAAATCCTAAAGAATCATTAAATGTAAATGTGCTGAAAAATGGTATGGAAGTATTAA
AAGGATATGGCAGCGGCAATTTAATAAAGAATAATAGCTTAAAAGATTGTATAAAAAATGGAGAAAATAGTATTAATCAA
TATGAAAACTATAATGATAAGCTAAGATATGATATAAAAATTTCTACATTGGAATTAGATCATTCTTGTCCTTGCATAGG
GTATGGATTTTATATTAATAGAAAACCTAAATTTAATCTAGAAAAAGCTGAAAGAAATAATGTGCCAAAGTTTTTATGGA
GTAGGCTTCAAAAAGGAGAAAGTTTAGTTTATGAAGGGATAAAATATAATCCCAGTATGGTTATGGGGAGAGACCGTAAA
GGAATAAAATTAAATTATGTTACAGATACAAGACCAATAGATCCTATAATAGATTTTATAAAAAATAGCGATTTGTTCAT
ATGTGAAGGAACTTATGGACGGGATGAAGATTTACATAAAGCCATAAAAAATAAACATATGACTTTTAGAGAAGGAGCTA
AGTTGGCTAACAAAGGTAAGGTGTCACAGCTTATATTAACGCATTTTAGTCCGGCTATGATAGATCCAGAAAGTTTTAAA
CAAAATGCTATAGAAGTTTTTCCAGATACTTTAATAGGGAAAGACAGACTTATTAAAACATTGTCTTTTAAGAAATAG

Upstream 100 bases:

>100_bases
TAATGACATATAATAATAATTAAGATATAAGTGAGTAACAATAAATGCAAATTATTAATATGAAAATAATATAAAAACTA
AAGTTAGGAGGAATAAAGTG

Downstream 100 bases:

>100_bases
TTATATATTTTTTAAGATTGAAACATAATTTATTACATGATAAAATATTTTTATTATAAAATATAATTTAAAATTTAATT
AAAGATGAATGAAGATTATT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITHMHGDHVVGLPGLLATIGNSG
REDPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKESLNVNVLKNGMEVLKGYGSGNLIKNNSLKDCIKNGENSINQ
YENYNDKLRYDIKISTLELDHSCPCIGYGFYINRKPKFNLEKAERNNVPKFLWSRLQKGESLVYEGIKYNPSMVMGRDRK
GIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGRDEDLHKAIKNKHMTFREGAKLANKGKVSQLILTHFSPAMIDPESFK
QNAIEVFPDTLIGKDRLIKTLSFKK

Sequences:

>Translated_345_residues
MDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITHMHGDHVVGLPGLLATIGNSG
REDPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKESLNVNVLKNGMEVLKGYGSGNLIKNNSLKDCIKNGENSINQ
YENYNDKLRYDIKISTLELDHSCPCIGYGFYINRKPKFNLEKAERNNVPKFLWSRLQKGESLVYEGIKYNPSMVMGRDRK
GIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGRDEDLHKAIKNKHMTFREGAKLANKGKVSQLILTHFSPAMIDPESFK
QNAIEVFPDTLIGKDRLIKTLSFKK
>Mature_345_residues
MDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITHMHGDHVVGLPGLLATIGNSG
REDPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKESLNVNVLKNGMEVLKGYGSGNLIKNNSLKDCIKNGENSINQ
YENYNDKLRYDIKISTLELDHSCPCIGYGFYINRKPKFNLEKAERNNVPKFLWSRLQKGESLVYEGIKYNPSMVMGRDRK
GIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGRDEDLHKAIKNKHMTFREGAKLANKGKVSQLILTHFSPAMIDPESFK
QNAIEVFPDTLIGKDRLIKTLSFKK

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=323, Percent_Identity=29.4117647058824, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI87082078, Length=345, Percent_Identity=28.9855072463768, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 38759; Mature: 38759

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITH
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCEEEEEEEEE
MHGDHVVGLPGLLATIGNSGREDPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKES
ECCCEEECCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCCHH
LNVNVLKNGMEVLKGYGSGNLIKNNSLKDCIKNGENSINQYENYNDKLRYDIKISTLELD
CCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHCCCHHHHHHCCCCCEEEEEEEEEEEEEC
HSCPCIGYGFYINRKPKFNLEKAERNNVPKFLWSRLQKGESLVYEGIKYNPSMVMGRDRK
CCCCEEEEEEEECCCCCCCCCHHHCCCCHHHHHHHHHCCCCEECCCCEECCCEEECCCCC
GIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGRDEDLHKAIKNKHMTFREGAKLANKGK
CEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHCCHHHCCCC
VSQLILTHFSPAMIDPESFKQNAIEVFPDTLIGKDRLIKTLSFKK
HHHHHHHHCCCCCCCHHHHHCCHHHHCCHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MDLALLGCGGGMPIPDRFLSSLLMNYRGRKILIDCGEGTQVSMKILGWGFKSIDIICITH
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCEEEEEEEEE
MHGDHVVGLPGLLATIGNSGREDPLTIIGPEGIENVITGLRTIVPYLPYDIVIIENPKES
ECCCEEECCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCCHH
LNVNVLKNGMEVLKGYGSGNLIKNNSLKDCIKNGENSINQYENYNDKLRYDIKISTLELD
CCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHCCCHHHHHHCCCCCEEEEEEEEEEEEEC
HSCPCIGYGFYINRKPKFNLEKAERNNVPKFLWSRLQKGESLVYEGIKYNPSMVMGRDRK
CCCCEEEEEEEECCCCCCCCCHHHCCCCHHHHHHHHHCCCCEECCCCEECCCEEECCCCC
GIKLNYVTDTRPIDPIIDFIKNSDLFICEGTYGRDEDLHKAIKNKHMTFREGAKLANKGK
CEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHCCHHHCCCC
VSQLILTHFSPAMIDPESFKQNAIEVFPDTLIGKDRLIKTLSFKK
HHHHHHHHCCCCCCCHHHHHCCHHHHCCHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA