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The map label for this gene is guaD [H]

Identifier: 226948555

GI number: 226948555

Start: 1498449

End: 1498922

Strand: Direct

Name: guaD [H]

Synonym: CLM_1447

Alternate gene names: 226948555

Gene position: 1498449-1498922 (Clockwise)

Preceding gene: 226948554

Following gene: 226948556

Centisome position: 36.06

GC content: 30.17

Gene sequence:

>474_bases
ATGAATAAAAATGAAATAATGGATTTATGTGTAAAGAGTTGTATGGAAGGCATGAAAAATCATGAAGGAGGTCCTTTTGG
ATCTGCAATAGTTAAGGATGGAGAAGTGATTGCAGTAGCTCATAATACTGTAGTAGGAGATAATGATCCCACTGCCCATG
GTGAAGTAAATGTTATAAGAAAAGCATGTAAAAAACTTAATACATTTGATTTAAGTGGATGTGAATTATATACAACATCA
GAACCTTGTCCTATGTGTATGTCTGCAATTATTTGGGCAAATATATCAAAAGTATATTATGGATGTACAGTAGAAGATGC
TAGAGATATTGGTTTTAGAGATGAGCACATATTAAAATTTTTAAAAGAAGGCTGCAAAGATAAAAATATACTTGATTTAG
AAGCAGTTGATAAAAAATCTTCTTTAAAAGCTTTTGAATATTGGAGTAAGGATAGAGACAAAACCAAATATTAA

Upstream 100 bases:

>100_bases
TATGATAATCACTACAAGGTAAGTTTTGACAAGATTATTTTTAAAGTATAATATTAAGATATATAGTTTAATTATTAAAT
GATTTTAAGAGGTTACTAAG

Downstream 100 bases:

>100_bases
AAGTAATAAGTTATAAAATAAATCCAGTAGCAAGCATTAAGAAGCTTTCTATTGGATTTTGTTTTAGTTTTTACTATGTA
TATTTTTAAATGTATAATTT

Product: guanine deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MNKNEIMDLCVKSCMEGMKNHEGGPFGSAIVKDGEVIAVAHNTVVGDNDPTAHGEVNVIRKACKKLNTFDLSGCELYTTS
EPCPMCMSAIIWANISKVYYGCTVEDARDIGFRDEHILKFLKEGCKDKNILDLEAVDKKSSLKAFEYWSKDRDKTKY

Sequences:

>Translated_157_residues
MNKNEIMDLCVKSCMEGMKNHEGGPFGSAIVKDGEVIAVAHNTVVGDNDPTAHGEVNVIRKACKKLNTFDLSGCELYTTS
EPCPMCMSAIIWANISKVYYGCTVEDARDIGFRDEHILKFLKEGCKDKNILDLEAVDKKSSLKAFEYWSKDRDKTKY
>Mature_157_residues
MNKNEIMDLCVKSCMEGMKNHEGGPFGSAIVKDGEVIAVAHNTVVGDNDPTAHGEVNVIRKACKKLNTFDLSGCELYTTS
EPCPMCMSAIIWANISKVYYGCTVEDARDIGFRDEHILKFLKEGCKDKNILDLEAVDKKSSLKAFEYWSKDRDKTKY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=78, Percent_Identity=35.8974358974359, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554608, Length=153, Percent_Identity=45.7516339869281, Blast_Score=149, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17555996, Length=154, Percent_Identity=43.5064935064935, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17566; Mature: 17566

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00127 RNASE_PANCREATIC ; PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.9 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNEIMDLCVKSCMEGMKNHEGGPFGSAIVKDGEVIAVAHNTVVGDNDPTAHGEVNVIR
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCEEEEECCEEECCCCCCCCCHHHHHH
KACKKLNTFDLSGCELYTTSEPCPMCMSAIIWANISKVYYGCTVEDARDIGFRDEHILKF
HHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHH
LKEGCKDKNILDLEAVDKKSSLKAFEYWSKDRDKTKY
HHHCCCCCCEEEHHHHCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNKNEIMDLCVKSCMEGMKNHEGGPFGSAIVKDGEVIAVAHNTVVGDNDPTAHGEVNVIR
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCEEEEECCEEECCCCCCCCCHHHHHH
KACKKLNTFDLSGCELYTTSEPCPMCMSAIIWANISKVYYGCTVEDARDIGFRDEHILKF
HHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHH
LKEGCKDKNILDLEAVDKKSSLKAFEYWSKDRDKTKY
HHHCCCCCCEEEHHHHCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]