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The map label for this gene is xdhA [H]

Identifier: 226948552

GI number: 226948552

Start: 1494633

End: 1496930

Strand: Direct

Name: xdhA [H]

Synonym: CLM_1444

Alternate gene names: 226948552

Gene position: 1494633-1496930 (Clockwise)

Preceding gene: 226948551

Following gene: 226948553

Centisome position: 35.97

GC content: 32.33

Gene sequence:

>2298_bases
ATGGAAGATTCTTATGATTTAATTGGAAAAAGCATAAATAGAGTAGATGCAGTAGCTAAAGTTACAGGTAGAGCTAAGTA
TTGCTCAGATCATTTTGAAGCTAATTCACTTGTAGGAATGGTTTTAAGAAGTCCCTATGCTCATGCAAAAGTAAAAAATA
TAGATACTAAAGAAGCTGAAAGCTTAGATGGTGTTGAAGCTGTATTAACGTATAAAAATGTACCAAATACGAAATTTCCT
ACGGCAGGACATCCATATTCATTAGATCCAAGTCATAGAGACATAGAAGATTATGTATTACTTACAGACAAAGCACGCTT
TGTAGGAGATGCAGTTGCAGCAGTTATTGCGACTGATGAACTTATAGCCAAAAAAGCCTTAAAATTAATAAAAGTAGAAT
ATGAAGTTTTGCCTTTTGTAATCGATCAAGAAGAAGCAATAAAAGAGGGAGCTCCTGTTATTCATGATGAAAGACCAAAT
AATATAGTTAGTGATTTTGGTATAACAGTAGGAGATCCAGATGAAGTATTTAAAAATGCAGATAAAATTTATAAAGGTCA
ATATGAAACTCAAATAGTGCAACATTGTCAAATGGAAACGCACAATGCTATGGCAAAGATTGATGAGAAAGGTAGAATGC
TTATTATAACATCAACACAAATACCACATATTGTACGAAGAATAGTTTCAAAAGCTTGTAATTTACCTATTGGTAAAATA
AGAGTAATAAAGCCTTATGTTGGCGGAGGCTTTGGAGGAAAGCAAGATGTTATAATAGAACCACTTACAGCTATAATGTC
TCTTGCAGTTAATGGAAGATGTGTAAGGTTACAATTAAGTAGAGAAGAGGCATTTGTTGCAACTAGAACAAGACATGCAA
TGAGAGTAAATATCAAAATAGCTTTATCAAAAGATAATAAAATAGAAGGTTATGATATAGAGAACTTTGTAAATAATGGA
GCTTATGCATCCCATGGACATTCAATTGCTATGAGTGCAGGAAGTAAAATTAGACCTCTTTATGATATAAAGGCAGAAAA
ATATCGCCCCAAAACTATATATACTAATCTTCCAGTTGCAGGTGCAATGAGAGCCTATGGTATACCACAAATGTGTTTTG
TTATAGAATCTATGATTGATGATATATGTAATGATCTAAATATAGACCCTGTAGATTTTAGACTTAATAGTTTTATAAAG
AAAGGTCATATAGATAAGACATCAGATCTTGTAGTTAGAACCTTTGGATTACCAGAATGTTTAAAAAGAGGTAGAAAATT
AATAGATTGGGACGGAAAAAGAGAATTATATAAAAATCAAAATGGTCCTATAAGAAAAGGTGTTGGAATGGCCTGTTTTA
GTTATTTTTCAGGAACTTGGCCAGTATCACTTGAGGCAGCGGGAACAAGAATAGTAATGAATCAAGATGGTTCAGTCCAA
GTTCAAGTAGGAGCTACAGAAATAGGACAGGGTAGTGATACAGTATTTAGTCAAATGGCAGCAGAAACTATTGGAATACC
ATTTGATATGGTAACAATAGTCTCACAGCAAGATACAGATATTACTCCTTTTGATACAGGATCCTATGCATCAAGACAAT
CTTTTATAGCAGGCCAAGCTATAAAAAAAGCAGCAACAGAAGTAAAAAGAAAAGTTCTAAAAATTGCCAGTGATAAATGT
GGATTAGATGCAGAGCTTTTGGATATTGTAGATGCAAAGGTGATAGAAAAAGGATTAAAGAGAGAACTTTATACTTTAGA
AGAAATTGCGATGGAGGCATATTACAATAGAGAAAAATATGCACCTATAACAAGTGATTTAACCGTAAAGGTTAAAAATA
ATGCTATAGCCTATGGGGCAACCTTTGTAGAAGTAGAAGTTGATATAAGAACAGGAAAAATAAAAGTTTTAGATATTTAT
AACATACATGATTCAGGAAAAATTTTAAATAAAAAGTTAGCAGAAGGACAAGTACACGGTGGTGTTAGTATGGCTTTAGG
ATTTGCCTTATCAGAAAAATTCATAATAGATGAGAAAACAGGATCTATAATAAACAATAATCTTTTACATTATAAACTTC
CAACTATTATGGATACTCCAAACATAAAATGTGAATTTGTAAATACCTATGATCCAACATCTAGTTATGGACAAAAATCT
TTAGGTGAAAATACAACAATCTCTCCAGCTCCAGCTATACGTAATGCCGTATTAAATGCAACAGGAGTAGCATTTAATAA
ATTGCCAATGGATGCTCAATCTGTTTTTGAGAAATTTAAAGAGGTTGGACTTATATAG

Upstream 100 bases:

>100_bases
CTAGTAAATATAAGAGAGAAGTAAAAGAAAAAAAAGAATCATAAAATAAATAATATATGTAGTTATTATAGAAGGCAAAA
TATTAAAGGGGGAACTATAC

Downstream 100 bases:

>100_bases
GAGGCGAAATAATATGTATGATATAAATGAAATTTTAGAACCTAAAACATTAGAAAAGGCATTAGAATTATTATCAGAAC
ACGATAATTTAACGGTAATA

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKIDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAFVATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKTSDLVVRTFGLPECLKRGRKLIDWDGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKVLKIASDKC
GLDAELLDIVDAKVIEKGLKRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI

Sequences:

>Translated_765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKIDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAFVATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKTSDLVVRTFGLPECLKRGRKLIDWDGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKVLKIASDKC
GLDAELLDIVDAKVIEKGLKRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
>Mature_765_residues
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAESLDGVEAVLTYKNVPNTKFP
TAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDELIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPN
NIVSDFGITVGDPDEVFKNADKIYKGQYETQIVQHCQMETHNAMAKIDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAFVATRTRHAMRVNIKIALSKDNKIEGYDIENFVNNG
AYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVAGAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIK
KGHIDKTSDLVVRTFGLPECLKRGRKLIDWDGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQAIKKAATEVKRKVLKIASDKC
GLDAELLDIVDAKVIEKGLKRELYTLEEIAMEAYYNREKYAPITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIY
NIHDSGKILNKKLAEGQVHGGVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=712, Percent_Identity=26.2640449438202, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI71773480, Length=737, Percent_Identity=26.4586160108548, Blast_Score=182, Evalue=8e-46,
Organism=Escherichia coli, GI1789230, Length=753, Percent_Identity=46.6135458167331, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=809, Percent_Identity=31.0259579728059, Blast_Score=356, Evalue=3e-99,
Organism=Escherichia coli, GI1786478, Length=778, Percent_Identity=27.120822622108, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17540638, Length=749, Percent_Identity=25.6341789052069, Blast_Score=176, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17539860, Length=738, Percent_Identity=24.1192411924119, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32566215, Length=737, Percent_Identity=24.2876526458616, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17737937, Length=743, Percent_Identity=27.0524899057873, Blast_Score=209, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24647193, Length=729, Percent_Identity=23.8683127572016, Blast_Score=149, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24647199, Length=722, Percent_Identity=21.4681440443213, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24647201, Length=739, Percent_Identity=23.2746955345061, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24647195, Length=728, Percent_Identity=22.3901098901099, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24647197, Length=716, Percent_Identity=22.7653631284916, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84419; Mature: 84419

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAE
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCCCEECCCCCHHHH
SLDGVEAVLTYKNVPNTKFPTAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDE
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
LIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPNNIVSDFGITVGDPDEVFKNA
HHHHHHHHHHHEEHHHCCEEECCHHHHHCCCCCEECCCCCCHHHHCCCCCCCHHHHHHCH
DKIYKGQYETQIVQHCQMETHNAMAKIDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCE
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAFVATRTRHAMRVNIKI
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCEEEEEEEEE
ALSKDNKIEGYDIENFVNNGAYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVA
EECCCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCEEEECCCCH
GAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIKKGHIDKTSDLVVRTFGLPEC
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCHHH
LKRGRKLIDWDGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
HHCCCEEECCCCCHHHHCCCCCCCHHCHHHHHHHHHCCCCCEEEECCCEEEEEECCCCEE
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQA
EEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
IKKAATEVKRKVLKIASDKCGLDAELLDIVDAKVIEKGLKRELYTLEEIAMEAYYNREKY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIYNIHDSGKILNKKLAEGQVHG
CCCCCCEEEEEECCEEEEEEEEEEEEEEEEECEEEEEEEEEECCCCHHHHHHHHCCCCCC
GVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
CHHHHHHHHHCCEEEEECCCCCHHCCCEEEEECCCEECCCCCEEEEEECCCCCCHHHHHH
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
CCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEDSYDLIGKSINRVDAVAKVTGRAKYCSDHFEANSLVGMVLRSPYAHAKVKNIDTKEAE
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCCCEECCCCCHHHH
SLDGVEAVLTYKNVPNTKFPTAGHPYSLDPSHRDIEDYVLLTDKARFVGDAVAAVIATDE
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
LIAKKALKLIKVEYEVLPFVIDQEEAIKEGAPVIHDERPNNIVSDFGITVGDPDEVFKNA
HHHHHHHHHHHEEHHHCCEEECCHHHHHCCCCCEECCCCCCHHHHCCCCCCCHHHHHHCH
DKIYKGQYETQIVQHCQMETHNAMAKIDEKGRMLIITSTQIPHIVRRIVSKACNLPIGKI
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCE
RVIKPYVGGGFGGKQDVIIEPLTAIMSLAVNGRCVRLQLSREEAFVATRTRHAMRVNIKI
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCEEEEEEEEE
ALSKDNKIEGYDIENFVNNGAYASHGHSIAMSAGSKIRPLYDIKAEKYRPKTIYTNLPVA
EECCCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCEEEECCCCH
GAMRAYGIPQMCFVIESMIDDICNDLNIDPVDFRLNSFIKKGHIDKTSDLVVRTFGLPEC
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCHHH
LKRGRKLIDWDGKRELYKNQNGPIRKGVGMACFSYFSGTWPVSLEAAGTRIVMNQDGSVQ
HHCCCEEECCCCCHHHHCCCCCCCHHCHHHHHHHHHCCCCCEEEECCCEEEEEECCCCEE
VQVGATEIGQGSDTVFSQMAAETIGIPFDMVTIVSQQDTDITPFDTGSYASRQSFIAGQA
EEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
IKKAATEVKRKVLKIASDKCGLDAELLDIVDAKVIEKGLKRELYTLEEIAMEAYYNREKY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APITSDLTVKVKNNAIAYGATFVEVEVDIRTGKIKVLDIYNIHDSGKILNKKLAEGQVHG
CCCCCCEEEEEECCEEEEEEEEEEEEEEEEECEEEEEEEEEECCCCHHHHHHHHCCCCCC
GVSMALGFALSEKFIIDEKTGSIINNNLLHYKLPTIMDTPNIKCEFVNTYDPTSSYGQKS
CHHHHHHHHHCCEEEEECCCCCHHCCCEEEEECCCEECCCCCEEEEEECCCCCCHHHHHH
LGENTTISPAPAIRNAVLNATGVAFNKLPMDAQSVFEKFKEVGLI
CCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]