Click here to switch to the map view.

The map label for this gene is panE [C]

Identifier: 226948437

GI number: 226948437

Start: 1382726

End: 1383637

Strand: Direct

Name: panE [C]

Synonym: CLM_1321

Alternate gene names: 226948437

Gene position: 1382726-1383637 (Clockwise)

Preceding gene: 226948436

Following gene: 226948438

Centisome position: 33.28

GC content: 26.97

Gene sequence:

>912_bases
ATGAAAATTGCTATAGTGGGTTCTGGAGCTATGGGATCCTTATATGGGGCTTATTTACATAAAAGTGGAGAGGAAGTTTA
TTTAATTAATAAATGGAAAGAACATATAAACACTATAAATAAAGTGGGATTAGTAATAGAAGAAGGAGATAAAAAATTAA
AGTTTTATCCAAAGGCTGTTACAAATTCTAAGGATATAAGTATAGTAGATTTGGCAATAGTATTTGTAAAATCTACAAAA
ACAGAGGAAGCAATTTTAGAAAATAAAAATATAATAGGAGAAAATACCTATGTTTTAACTCTTCAAAATGGATATGGAAA
TGGAGAAAAAATAGAAAAATATATAAATAAGAATAGAATAATAGTAGGAACTACTGGTGAAGGATGTACTACCATAAAGG
CAGGATATATAAAACATGCAGGTTCAGGAGATACTTACATAGGTATGTTTTCTGGGAAAGAAGATAATATTTTAAAAAGG
TTAGAAAATATTTTAAATAATAGCGGTTTTAATGCACATATATGCAAAGATCCTAGAGAACTTATCTGGGATAAACTTAT
TATAAATATTGGAATTAATGCTATAACAGCTATTTTAGGTATAAAAAATGGTGAAATTTTAAAGGAAATGGCTACAAAAA
AAATTATGAAAGATGCGGTTATAGAGGCAGTAAAGGTAGCTAATGCTAAAGGTCTTAGTTTTAATGAGGAAGAAATGATA
AAAAAAGTAGAAAATGTAGCCTTAAAAACAGCAGAAAATAAATCCTCTATGTTGCAAGATGTTCTAAATAATAAAAAAAC
AGAAATAGAGAATATAAATGGAGCTATTGTAAAAGAAGGAAGTAAATTTAATATAAAGACACCTGTAAACGAAACTCTAA
CTAATTTAATAATTTCTCTAGAAAAGAAATAG

Upstream 100 bases:

>100_bases
TTAGCACAATTATTTTTATTCATTTGAGTATTATTAACCGGAGAATGGTATAAGAATATTAAAAATGGGATAAAAAATTA
ATAAATTTGGGGGAGAGAAT

Downstream 100 bases:

>100_bases
GCTTCTAACACTGCAAAGATAAAAAATATGCTCATAAATCAATTCATTTCTCTAATAAGTTTTAAATCTGACTTCATTAA
AATTATATTAAAGTTAAATT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAVTNSKDISIVDLAIVFVKSTK
TEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRIIVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEMATKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTPVNETLTNLIISLEKK

Sequences:

>Translated_303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAVTNSKDISIVDLAIVFVKSTK
TEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRIIVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEMATKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTPVNETLTNLIISLEKK
>Mature_303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAVTNSKDISIVDLAIVFVKSTK
TEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRIIVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEMATKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTPVNETLTNLIISLEKK

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=298, Percent_Identity=28.8590604026846, Blast_Score=101, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33419; Mature: 33419

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAV
CEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHEEEEECCCCEEEEEEHHH
TNSKDISIVDLAIVFVKSTKTEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRI
CCCCCCEEEEEEEEEEECCCHHHHHHHCCCEECCCEEEEEEECCCCCHHHHHHHHCCCCE
IVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKRLENILNNSGFNAHICKDPRE
EEEECCCCCEEEEECCEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHH
LIWDKLIINIGINAITAILGIKNGEILKEMATKKIMKDAVIEAVKVANAKGLSFNEEEMI
HHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTPVNETLTNLIISL
HHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCCCCEEEECCCEEEEECCHHHHHHHHHHEE
EKK
CCC
>Mature Secondary Structure
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINKVGLVIEEGDKKLKFYPKAV
CEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHEEEEECCCCEEEEEEHHH
TNSKDISIVDLAIVFVKSTKTEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRI
CCCCCCEEEEEEEEEEECCCHHHHHHHCCCEECCCEEEEEEECCCCCHHHHHHHHCCCCE
IVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKRLENILNNSGFNAHICKDPRE
EEEECCCCCEEEEECCEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHH
LIWDKLIINIGINAITAILGIKNGEILKEMATKKIMKDAVIEAVKVANAKGLSFNEEEMI
HHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTPVNETLTNLIISL
HHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCCCCEEEECCCEEEEECCHHHHHHHHHHEE
EKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]