Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 226947772

GI number: 226947772

Start: 672542

End: 673573

Strand: Direct

Name: phoR [H]

Synonym: CLM_0621

Alternate gene names: 226947772

Gene position: 672542-673573 (Clockwise)

Preceding gene: 226947771

Following gene: 226947773

Centisome position: 16.19

GC content: 26.65

Gene sequence:

>1032_bases
ATGAAATCAAAAAAGTTGTCTATTAAATACATTTGCTTACTGATATTTATTGGTGCTTTTTTAACATCAACTATTTTTAT
TATTCCTGTATATATGATTACTAAAAATAAGATTATTATTTTATGTACCAGTATGTTTGTTTTATGTATATGCATATGGT
TTGTAATATTTATGCTCCTAATAAGGAAAAAATTATTATTATTTATTTCTAATATTTCATGTTCATTAGATAAAATGATG
AATGGTAATAGTAACATCTATGTTAACTTAGAGGAAGAAACCTTATTATCAAAAGTTAATTATAAGATGAAAAGACTGTC
TGAAATTATGAAAGAAAATAATAGTAGAGTTTCCCGGGAAAAAGCTGATCTTGAAAAATTAGTTTCAGATATTTCTCATC
AAGTAAAAACTCCTATAGCAAATCTAAAGATGATTAATGCTACTTTATTACAGGGTAATGTATCAGAAAAAGAACAAATA
GATTTTTTAAGATCAATGGATGGTCAGCTTGATAAGCTAGATTTCCTAATGCAATCTATGATAAAGACTTCAAGGCTTGA
AACAGGAATAATAACTTTAGAGAAAAAGAATTATTCCATTTATGAAACCATTGCAGCAGTAATGGGAGCTATTTTATTTA
AAGCTGAAAAAAAGAAAATACAAATTACGGTTAATTGTGATGCTAATTTATTTGCTTTACATGATAGAAAATGGACAACT
GAGGCATTATTTAATATTGTAGATAATGCTGTAAAATATACTCCTGTAGGTGGTGAGATTCATATAAATTGTTCAAAATT
AGAAATGTATACTAGAATTGATATAATAGATAATGGCAGGGGTATAAAAGAAAGCCATCAAGCTGAAATTTTCAAACGAT
TTTATAGAGAAAAAGATGTACATGACCTTCCTGGTATTGGTATTGGGTTATACTTGGCTCGTGAAATTATAACAATGGAA
GATGGTTATATTAAAGTAATATCTAAAGAAGGAGAAGGTTCTACATTTTCTGTATTTCTGTTAAATAGCTAA

Upstream 100 bases:

>100_bases
CAGTTATTAGTCGTATTAGAAATAAAATAGAAGCAGAAGAAACTCAATATATTAAAACCGTATATGGAATGGGATATATG
TGGATAGGTGATGACAGAAA

Downstream 100 bases:

>100_bases
ATTAGTAATGGAATTTTTAATAGGGTATCTCAAGATTATATCTATTTTGAGATACCTTTTCATATTATTTGTAACTTTTT
TATCTAGTAATATTTTCAAA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKSKKLSIKYICLLIFIGAFLTSTIFIIPVYMITKNKIIILCTSMFVLCICIWFVIFMLLIRKKLLLFISNISCSLDKMM
NGNSNIYVNLEEETLLSKVNYKMKRLSEIMKENNSRVSREKADLEKLVSDISHQVKTPIANLKMINATLLQGNVSEKEQI
DFLRSMDGQLDKLDFLMQSMIKTSRLETGIITLEKKNYSIYETIAAVMGAILFKAEKKKIQITVNCDANLFALHDRKWTT
EALFNIVDNAVKYTPVGGEIHINCSKLEMYTRIDIIDNGRGIKESHQAEIFKRFYREKDVHDLPGIGIGLYLAREIITME
DGYIKVISKEGEGSTFSVFLLNS

Sequences:

>Translated_343_residues
MKSKKLSIKYICLLIFIGAFLTSTIFIIPVYMITKNKIIILCTSMFVLCICIWFVIFMLLIRKKLLLFISNISCSLDKMM
NGNSNIYVNLEEETLLSKVNYKMKRLSEIMKENNSRVSREKADLEKLVSDISHQVKTPIANLKMINATLLQGNVSEKEQI
DFLRSMDGQLDKLDFLMQSMIKTSRLETGIITLEKKNYSIYETIAAVMGAILFKAEKKKIQITVNCDANLFALHDRKWTT
EALFNIVDNAVKYTPVGGEIHINCSKLEMYTRIDIIDNGRGIKESHQAEIFKRFYREKDVHDLPGIGIGLYLAREIITME
DGYIKVISKEGEGSTFSVFLLNS
>Mature_343_residues
MKSKKLSIKYICLLIFIGAFLTSTIFIIPVYMITKNKIIILCTSMFVLCICIWFVIFMLLIRKKLLLFISNISCSLDKMM
NGNSNIYVNLEEETLLSKVNYKMKRLSEIMKENNSRVSREKADLEKLVSDISHQVKTPIANLKMINATLLQGNVSEKEQI
DFLRSMDGQLDKLDFLMQSMIKTSRLETGIITLEKKNYSIYETIAAVMGAILFKAEKKKIQITVNCDANLFALHDRKWTT
EALFNIVDNAVKYTPVGGEIHINCSKLEMYTRIDIIDNGRGIKESHQAEIFKRFYREKDVHDLPGIGIGLYLAREIITME
DGYIKVISKEGEGSTFSVFLLNS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=313, Percent_Identity=23.961661341853, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=211, Percent_Identity=28.436018957346, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=23.9543726235741, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=215, Percent_Identity=25.1162790697674, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=294, Percent_Identity=24.8299319727891, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788549, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=20.4545454545455, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=25.974025974026, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=23.5294117647059, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=23.7668161434978, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=22.7891156462585, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=22.5663716814159, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39281; Mature: 39281

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLSIKYICLLIFIGAFLTSTIFIIPVYMITKNKIIILCTSMFVLCICIWFVIFMLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEHHHHHHHHHHHHHHHHHHH
IRKKLLLFISNISCSLDKMMNGNSNIYVNLEEETLLSKVNYKMKRLSEIMKENNSRVSRE
HHHHHHHHHHCCCHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KADLEKLVSDISHQVKTPIANLKMINATLLQGNVSEKEQIDFLRSMDGQLDKLDFLMQSM
HHHHHHHHHHHHHHHHCCHHHHEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
IKTSRLETGIITLEKKNYSIYETIAAVMGAILFKAEKKKIQITVNCDANLFALHDRKWTT
HHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCHHH
EALFNIVDNAVKYTPVGGEIHINCSKLEMYTRIDIIDNGRGIKESHQAEIFKRFYREKDV
HHHHHHHHCCEEECCCCCEEEEEEHHEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
HDLPGIGIGLYLAREIITMEDGYIKVISKEGEGSTFSVFLLNS
CCCCCCCHHHHHHHHHHEECCCEEEEEEECCCCCEEEEEEECC
>Mature Secondary Structure
MKSKKLSIKYICLLIFIGAFLTSTIFIIPVYMITKNKIIILCTSMFVLCICIWFVIFMLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEHHHHHHHHHHHHHHHHHHH
IRKKLLLFISNISCSLDKMMNGNSNIYVNLEEETLLSKVNYKMKRLSEIMKENNSRVSRE
HHHHHHHHHHCCCHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KADLEKLVSDISHQVKTPIANLKMINATLLQGNVSEKEQIDFLRSMDGQLDKLDFLMQSM
HHHHHHHHHHHHHHHHCCHHHHEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
IKTSRLETGIITLEKKNYSIYETIAAVMGAILFKAEKKKIQITVNCDANLFALHDRKWTT
HHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCHHH
EALFNIVDNAVKYTPVGGEIHINCSKLEMYTRIDIIDNGRGIKESHQAEIFKRFYREKDV
HHHHHHHHCCEEECCCCCEEEEEEHHEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
HDLPGIGIGLYLAREIITMEDGYIKVISKEGEGSTFSVFLLNS
CCCCCCCHHHHHHHHHHEECCCEEEEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]