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The map label for this gene is adk

Identifier: 226225156

GI number: 226225156

Start: 2661276

End: 2661923

Strand: Reverse

Name: adk

Synonym: Lm4b_02578

Alternate gene names: 226225156

Gene position: 2661923-2661276 (Counterclockwise)

Preceding gene: 226225157

Following gene: 226225155

Centisome position: 91.39

GC content: 38.73

Gene sequence:

>648_bases
TTGAAATTAGTATTAATGGGACTGCCCGGCGCCGGAAAAGGCACACAAGCGGAACAGATTGTTGAGAAATACAACATTCC
TCATATTTCCACTGGAGATATGTTCCGAGCAGCTATGAAAAATAATACGGAATTAGGAAAGAAAGCTAAATCCTTTATGG
ATAATGGCGACCTTGTTCCTGATGAAGTAACAAATGGTATCGTTCGTGAACGTTTGGCCGAAGATGATGCTAAGAATGGT
TTCTTGCTTGATGGTTTTCCGCGCACTGTGGAACAAGCAGAAGAGCTAGAAAATATTCTAAATGATTTAGGGACAGAACT
TGATGCTGTCATTAACATTGAAGTTGATAAAGATGTTTTAATGAAACGTCTTACAGGTCGTTGGATTTGTCGGACTTGCG
GTAAGACTTACCATGAAATTTACAACCCACCGAAAGTTCCTGGGAAATGTGATTTAGATGGCGGAGAACTTTACCAACGC
GATGACGACAAGAAAGAAACGGTTGAAAAACGACTAAATGTAAATATGAAACAGACCAAGCCGCTTCTAGATTTTTATTC
TGAAAAGGGTAAACTTCATAACATAAACGGCGAGCAAGACATTAAAGACGTTTTTGTAGATGTGGAAAAAATTCTTGCTT
CTTTTTGA

Upstream 100 bases:

>100_bases
GACAACTTGTAAAAAGGAACTATCGGGGATTTATCAAATAACACGCAGTTCTTGTTAGGTCTTCCTAGCAGGAGCTAGCG
CGTAATAAGGGGCGAAACAG

Downstream 100 bases:

>100_bases
GGAGTGAGCTGTGCTGAATCACTGTCAAAATCAATGCGTGCAAATTAGTTTAGTTTGTAGTATAATGGATAATTGGCAGT
GGAATTAAAGGCATCTAAGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MKLVLMGLPGAGKGTQAEQIVEKYNIPHISTGDMFRAAMKNNTELGKKAKSFMDNGDLVPDEVTNGIVRERLAEDDAKNG
FLLDGFPRTVEQAEELENILNDLGTELDAVINIEVDKDVLMKRLTGRWICRTCGKTYHEIYNPPKVPGKCDLDGGELYQR
DDDKKETVEKRLNVNMKQTKPLLDFYSEKGKLHNINGEQDIKDVFVDVEKILASF

Sequences:

>Translated_215_residues
MKLVLMGLPGAGKGTQAEQIVEKYNIPHISTGDMFRAAMKNNTELGKKAKSFMDNGDLVPDEVTNGIVRERLAEDDAKNG
FLLDGFPRTVEQAEELENILNDLGTELDAVINIEVDKDVLMKRLTGRWICRTCGKTYHEIYNPPKVPGKCDLDGGELYQR
DDDKKETVEKRLNVNMKQTKPLLDFYSEKGKLHNINGEQDIKDVFVDVEKILASF
>Mature_215_residues
MKLVLMGLPGAGKGTQAEQIVEKYNIPHISTGDMFRAAMKNNTELGKKAKSFMDNGDLVPDEVTNGIVRERLAEDDAKNG
FLLDGFPRTVEQAEELENILNDLGTELDAVINIEVDKDVLMKRLTGRWICRTCGKTYHEIYNPPKVPGKCDLDGGELYQR
DDDKKETVEKRLNVNMKQTKPLLDFYSEKGKLHNINGEQDIKDVFVDVEKILASF

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=43.2558139534884, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=43.2558139534884, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI19923437, Length=203, Percent_Identity=44.3349753694581, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=37.8109452736318, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=37.8109452736318, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=37.8109452736318, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=37.8109452736318, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=31.8840579710145, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI28144899, Length=211, Percent_Identity=32.2274881516588, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI28144897, Length=211, Percent_Identity=32.2274881516588, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI7706497, Length=215, Percent_Identity=28.3720930232558, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI22749187, Length=210, Percent_Identity=29.0476190476191, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=47.0046082949309, Blast_Score=205, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=40.4651162790698, Blast_Score=180, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=33.9805825242718, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=32.093023255814, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17533833, Length=212, Percent_Identity=29.2452830188679, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=26.2910798122066, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=42.5837320574163, Blast_Score=188, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=34.6938775510204, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=210, Percent_Identity=27.1428571428571, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI22026816, Length=209, Percent_Identity=44.0191387559809, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=39.6984924623116, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=39.6984924623116, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24663208, Length=205, Percent_Identity=28.780487804878, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647141, Length=205, Percent_Identity=28.780487804878, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=27.2300469483568, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=27.2300469483568, Blast_Score=94, Evalue=9e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24233; Mature: 24233

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVLMGLPGAGKGTQAEQIVEKYNIPHISTGDMFRAAMKNNTELGKKAKSFMDNGDLVP
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCH
DEVTNGIVRERLAEDDAKNGFLLDGFPRTVEQAEELENILNDLGTELDAVINIEVDKDVL
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHEEEEEEECCHHHH
MKRLTGRWICRTCGKTYHEIYNPPKVPGKCDLDGGELYQRDDDKKETVEKRLNVNMKQTK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCHHHHH
PLLDFYSEKGKLHNINGEQDIKDVFVDVEKILASF
HHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLVLMGLPGAGKGTQAEQIVEKYNIPHISTGDMFRAAMKNNTELGKKAKSFMDNGDLVP
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCH
DEVTNGIVRERLAEDDAKNGFLLDGFPRTVEQAEELENILNDLGTELDAVINIEVDKDVL
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHEEEEEEECCHHHH
MKRLTGRWICRTCGKTYHEIYNPPKVPGKCDLDGGELYQRDDDKKETVEKRLNVNMKQTK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCHHHHH
PLLDFYSEKGKLHNINGEQDIKDVFVDVEKILASF
HHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]