Click here to switch to the map view.

The map label for this gene is atpB

Identifier: 226225083

GI number: 226225083

Start: 2584222

End: 2584938

Strand: Reverse

Name: atpB

Synonym: Lm4b_02504

Alternate gene names: 226225083

Gene position: 2584938-2584222 (Counterclockwise)

Preceding gene: 226225084

Following gene: 226225082

Centisome position: 88.75

GC content: 37.1

Gene sequence:

>717_bases
TTGGAAGAGGAATTTCCAACGATAAGCCTATTAGGGATCGACTTTAATCTATCTAATATTTTGATGATTACTGTGACTTG
TGTCATCGTTCTTCTAATAGCCATTATCTGTACCAGAAATCTGCAACGCCGACCTACCGGAAAGCAGAACTTCATTGAAT
GGGTTATGGATTTTGTCAGAGGTATTATTAATAGTAATATGGATTGGAAAACCGGTGGGAGATTCCATGTACTTGGTATT
ACGCTACTAATGTTTATTTTCGTAGCTAATATGCTAGGACTGCCATTTCAAATCGCGATTAACGATGAAGTATGGTGGCG
TTCACCTACAGCGGATCCAATTGTCACATTAACACTTGCGATAATGGTTCTTGGCTTAACGCATTACTATGGTATTAAAA
TGCGTGGTTTCAAGCACTATTTTGTTGGCACTTACTTTAGTCCAATGAAATTTTTATTCCCACTTAAATTAGTAGAAGAA
TTTGCTAATACTTTAACGCTTGGTTTACGTCTTTACGGTAATATTTTTGCCGGCGAAGTTTTGTTAACCATCATTGCAAC
ACAACTTGCTCATATGAACATATTTGTAGGTGTGCTAGCAATAATTCCTGCGTTACTATGGCAAGGATTCTCAATTTTCA
TTGGGGCAATTCAAGCGTACATTTTCACTATGCTGACCATGGTTTATATGTCGCATAAGGTAAGTGACGAACATTAA

Upstream 100 bases:

>100_bases
AATCGGACTTGGGCTTGCATATGCAATTATTTTTCTAGATTTTTTTGTGTATTCCATGTACCGCAGAAAAAAGTTTTTAA
AAAGAGAGGGGTGAACCTAA

Downstream 100 bases:

>100_bases
ACTAACTTTCAAATAAGTCATTTATAAAAGTAATAAAAAATAATATTTAGAAAAATTAGGAGGATAATTATATGTCTTTA
GGTGTTATTGCAGCTGCTAT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MEEEFPTISLLGIDFNLSNILMITVTCVIVLLIAIICTRNLQRRPTGKQNFIEWVMDFVRGIINSNMDWKTGGRFHVLGI
TLLMFIFVANMLGLPFQIAINDEVWWRSPTADPIVTLTLAIMVLGLTHYYGIKMRGFKHYFVGTYFSPMKFLFPLKLVEE
FANTLTLGLRLYGNIFAGEVLLTIIATQLAHMNIFVGVLAIIPALLWQGFSIFIGAIQAYIFTMLTMVYMSHKVSDEH

Sequences:

>Translated_238_residues
MEEEFPTISLLGIDFNLSNILMITVTCVIVLLIAIICTRNLQRRPTGKQNFIEWVMDFVRGIINSNMDWKTGGRFHVLGI
TLLMFIFVANMLGLPFQIAINDEVWWRSPTADPIVTLTLAIMVLGLTHYYGIKMRGFKHYFVGTYFSPMKFLFPLKLVEE
FANTLTLGLRLYGNIFAGEVLLTIIATQLAHMNIFVGVLAIIPALLWQGFSIFIGAIQAYIFTMLTMVYMSHKVSDEH
>Mature_238_residues
MEEEFPTISLLGIDFNLSNILMITVTCVIVLLIAIICTRNLQRRPTGKQNFIEWVMDFVRGIINSNMDWKTGGRFHVLGI
TLLMFIFVANMLGLPFQIAINDEVWWRSPTADPIVTLTLAIMVLGLTHYYGIKMRGFKHYFVGTYFSPMKFLFPLKLVEE
FANTLTLGLRLYGNIFAGEVLLTIIATQLAHMNIFVGVLAIIPALLWQGFSIFIGAIQAYIFTMLTMVYMSHKVSDEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=219, Percent_Identity=31.0502283105023, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_LISIN (Q927V8)

Other databases:

- EMBL:   AL596173
- PIR:   AI1766
- RefSeq:   NP_472008.1
- ProteinModelPortal:   Q927V8
- SMR:   Q927V8
- GeneID:   1131520
- GenomeReviews:   AL592022_GR
- KEGG:   lin:lin2679
- GenoList:   LIN2679
- HOGENOM:   HBG734175
- OMA:   LHGQVFL
- ProtClustDB:   PRK05815
- BioCyc:   LINN272626:LIN2679-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27082; Mature: 27082

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2087703c)-; HASH(0x20e5e0a0)-; HASH(0x204f9d80)-; HASH(0x20aba420)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEEFPTISLLGIDFNLSNILMITVTCVIVLLIAIICTRNLQRRPTGKQNFIEWVMDFVR
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
GIINSNMDWKTGGRFHVLGITLLMFIFVANMLGLPFQIAINDEVWWRSPTADPIVTLTLA
HHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCHHHHHHHH
IMVLGLTHYYGIKMRGFKHYFVGTYFSPMKFLFPLKLVEEFANTLTLGLRLYGNIFAGEV
HHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTIIATQLAHMNIFVGVLAIIPALLWQGFSIFIGAIQAYIFTMLTMVYMSHKVSDEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MEEEFPTISLLGIDFNLSNILMITVTCVIVLLIAIICTRNLQRRPTGKQNFIEWVMDFVR
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
GIINSNMDWKTGGRFHVLGITLLMFIFVANMLGLPFQIAINDEVWWRSPTADPIVTLTLA
HHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCHHHHHHHH
IMVLGLTHYYGIKMRGFKHYFVGTYFSPMKFLFPLKLVEEFANTLTLGLRLYGNIFAGEV
HHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTIIATQLAHMNIFVGVLAIIPALLWQGFSIFIGAIQAYIFTMLTMVYMSHKVSDEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11679669