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The map label for this gene is murA

Identifier: 226225074

GI number: 226225074

Start: 2576605

End: 2577897

Strand: Reverse

Name: murA

Synonym: Lm4b_02495

Alternate gene names: 226225074

Gene position: 2577897-2576605 (Counterclockwise)

Preceding gene: 226225075

Following gene: 226225073

Centisome position: 88.51

GC content: 38.44

Gene sequence:

>1293_bases
TTGGAAAAAATTATTGTACGCGGTGGAAAACAGTTAAATGGTTCTGTGAAAATGGAAGGTGCCAAGAATGCTGTATTACC
GGTAATAGCTGCTACATTACTTGCGAGTAAAGGTACTAGCGTATTAAAAAATGTCCCAAACTTGTCTGATGTATTCACAA
TCAATGAGGTTCTTAAATATCTAAATGCAGATGTTTCTTTTGTAAATGATGAAGTAACAGTCAATGCAACAGGAGAAATC
ACTTCTGATGCACCTTTTGAGTACGTTCGTAAAATGCGTGCTTCCATTGTTGTAATGGGACCACTTTTGGCACGTACTGG
TTCAGCACGTGTAGCTTTACCTGGTGGATGTGCAATTGGCTCAAGACCAGTTGACTTACATTTAAAAGGTTTTGAAGCAA
TGGGCGCAATCGTGAAAATTGAAAATGGCTATATTGAAGCAACTGCTGAAAAATTAGTTGGTGCTAAAGTATACTTAGAT
TTCCCAAGTGTTGGAGCGACACAAAATATTATGATGGCTGCTACTCTAGCAGAAGGTACTACAGTAATAGAAAACGTGGC
TCGTGAACCTGAAATTGTCGACTTAGCAAACTTCCTTAACCAAATGGGTGCTAGAGTTATCGGTGCAGGAACAGAAGTAA
TTAGAATTGAAGGAGTTAAAGAATTAACTGCAACTGAACATTCTATTATTCCAGACCGTATTGAAGCAGGAACATTTATG
ATTGCTGCTGCGATTACTGGTGGAAATGTTTTAATTGAAGATGCAGTTCCCGAGCATATTAGTTCGTTAATTGCTAAACT
TGAAGAAATGGGCGTTCAAATCATTGAAGAAGAGAATGGGATTCGTGTAATTGGTCCTGATAAATTAAAAGCTGTGGATG
TTAAAACGATGCCACACCCAGGTTTTCCAACAGATATGCAATCGCAAATGATGGTTATTCAAATGCTGAGTGAAGGAACA
AGCATCATGACTGAAACTGTTTTTGAGAATCGTTTTATGCATGTAGAAGAAATGCGTAGAATGAACGCTGATATGAAAAT
TGAAGGACATTCTGTTATTATTTCTGGCCCAGCTAAATTACAAGGAGCAGAAGTTGCTGCGACAGATTTACGTGCAGCAG
CAGCGCTTATTCTTGCTGGTTTAGTTGCAGATGGCTATACACAAGTAACTGAGTTAAAATACCTTGATCGTGGCTATAAT
AATTTCCACGGCAAACTACAAGCGCTTGGTGCTGATGTGGAACGTGTAGATGATTCCAAAATCGATGTAACAAACTTAGC
GTCTTTATTCTAA

Upstream 100 bases:

>100_bases
GTGATAAGTGGTAGAATTACTTAGATATGTTTTAAATTCAAATTTTGATTAATAAAATTCGATAAATGATTTAGTTATTA
GTAACGCGGAGGGGTTCTTT

Downstream 100 bases:

>100_bases
ATTTAAATGTTAAAAACCGTATCTTCTTGATGCGGTTTTTTTATTTGTCATGAAAAATTCCGCATTGCTATAAAATATAC
ATTTCAGCCGCACATAAATT

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 1; UDP-N-acetylglucosamine enolpyruvyl transferase 1; EPT 1 [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MEKIIVRGGKQLNGSVKMEGAKNAVLPVIAATLLASKGTSVLKNVPNLSDVFTINEVLKYLNADVSFVNDEVTVNATGEI
TSDAPFEYVRKMRASIVVMGPLLARTGSARVALPGGCAIGSRPVDLHLKGFEAMGAIVKIENGYIEATAEKLVGAKVYLD
FPSVGATQNIMMAATLAEGTTVIENVAREPEIVDLANFLNQMGARVIGAGTEVIRIEGVKELTATEHSIIPDRIEAGTFM
IAAAITGGNVLIEDAVPEHISSLIAKLEEMGVQIIEEENGIRVIGPDKLKAVDVKTMPHPGFPTDMQSQMMVIQMLSEGT
SIMTETVFENRFMHVEEMRRMNADMKIEGHSVIISGPAKLQGAEVAATDLRAAAALILAGLVADGYTQVTELKYLDRGYN
NFHGKLQALGADVERVDDSKIDVTNLASLF

Sequences:

>Translated_430_residues
MEKIIVRGGKQLNGSVKMEGAKNAVLPVIAATLLASKGTSVLKNVPNLSDVFTINEVLKYLNADVSFVNDEVTVNATGEI
TSDAPFEYVRKMRASIVVMGPLLARTGSARVALPGGCAIGSRPVDLHLKGFEAMGAIVKIENGYIEATAEKLVGAKVYLD
FPSVGATQNIMMAATLAEGTTVIENVAREPEIVDLANFLNQMGARVIGAGTEVIRIEGVKELTATEHSIIPDRIEAGTFM
IAAAITGGNVLIEDAVPEHISSLIAKLEEMGVQIIEEENGIRVIGPDKLKAVDVKTMPHPGFPTDMQSQMMVIQMLSEGT
SIMTETVFENRFMHVEEMRRMNADMKIEGHSVIISGPAKLQGAEVAATDLRAAAALILAGLVADGYTQVTELKYLDRGYN
NFHGKLQALGADVERVDDSKIDVTNLASLF
>Mature_430_residues
MEKIIVRGGKQLNGSVKMEGAKNAVLPVIAATLLASKGTSVLKNVPNLSDVFTINEVLKYLNADVSFVNDEVTVNATGEI
TSDAPFEYVRKMRASIVVMGPLLARTGSARVALPGGCAIGSRPVDLHLKGFEAMGAIVKIENGYIEATAEKLVGAKVYLD
FPSVGATQNIMMAATLAEGTTVIENVAREPEIVDLANFLNQMGARVIGAGTEVIRIEGVKELTATEHSIIPDRIEAGTFM
IAAAITGGNVLIEDAVPEHISSLIAKLEEMGVQIIEEENGIRVIGPDKLKAVDVKTMPHPGFPTDMQSQMMVIQMLSEGT
SIMTETVFENRFMHVEEMRRMNADMKIEGHSVIISGPAKLQGAEVAATDLRAAAALILAGLVADGYTQVTELKYLDRGYN
NFHGKLQALGADVERVDDSKIDVTNLASLF

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine [H]

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789580, Length=418, Percent_Identity=50, Blast_Score=402, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.7 [H]

Molecular weight: Translated: 46007; Mature: 46007

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIIVRGGKQLNGSVKMEGAKNAVLPVIAATLLASKGTSVLKNVPNLSDVFTINEVLKY
CCCEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHH
LNADVSFVNDEVTVNATGEITSDAPFEYVRKMRASIVVMGPLLARTGSARVALPGGCAIG
HCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHCEEEECHHHHCCCCCEEECCCCCCCC
SRPVDLHLKGFEAMGAIVKIENGYIEATAEKLVGAKVYLDFPSVGATQNIMMAATLAEGT
CCCEEEEEECHHHCCEEEEEECCEEEEEHHHHCCEEEEEECCCCCCCCCEEEEEEHHCCH
TVIENVAREPEIVDLANFLNQMGARVIGAGTEVIRIEGVKELTATEHSIIPDRIEAGTFM
HHHHHHHCCCCHHHHHHHHHHHCCEEEECCCEEEEECCCHHHHHCCCCCCCCHHCCCEEE
IAAAITGGNVLIEDAVPEHISSLIAKLEEMGVQIIEEENGIRVIGPDKLKAVDVKTMPHP
EEEEECCCCEEEECCCHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCEEEEEEECCCCC
GFPTDMQSQMMVIQMLSEGTSIMTETVFENRFMHVEEMRRMNADMKIEGHSVIISGPAKL
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHCCCCEEECCCEEEEECCCCC
QGAEVAATDLRAAAALILAGLVADGYTQVTELKYLDRGYNNFHGKLQALGADVERVDDSK
CCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHCCCCC
IDVTNLASLF
CCHHHHHHCC
>Mature Secondary Structure
MEKIIVRGGKQLNGSVKMEGAKNAVLPVIAATLLASKGTSVLKNVPNLSDVFTINEVLKY
CCCEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHH
LNADVSFVNDEVTVNATGEITSDAPFEYVRKMRASIVVMGPLLARTGSARVALPGGCAIG
HCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHCEEEECHHHHCCCCCEEECCCCCCCC
SRPVDLHLKGFEAMGAIVKIENGYIEATAEKLVGAKVYLDFPSVGATQNIMMAATLAEGT
CCCEEEEEECHHHCCEEEEEECCEEEEEHHHHCCEEEEEECCCCCCCCCEEEEEEHHCCH
TVIENVAREPEIVDLANFLNQMGARVIGAGTEVIRIEGVKELTATEHSIIPDRIEAGTFM
HHHHHHHCCCCHHHHHHHHHHHCCEEEECCCEEEEECCCHHHHHCCCCCCCCHHCCCEEE
IAAAITGGNVLIEDAVPEHISSLIAKLEEMGVQIIEEENGIRVIGPDKLKAVDVKTMPHP
EEEEECCCCEEEECCCHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCEEEEEEECCCCC
GFPTDMQSQMMVIQMLSEGTSIMTETVFENRFMHVEEMRRMNADMKIEGHSVIISGPAKL
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHCCCCEEECCCEEEEECCCCC
QGAEVAATDLRAAAALILAGLVADGYTQVTELKYLDRGYNNFHGKLQALGADVERVDDSK
CCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHCCCCC
IDVTNLASLF
CCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]