| Definition | Listeria monocytogenes Clip81459, complete genome. |
|---|---|
| Accession | NC_012488 |
| Length | 2,912,690 |
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The map label for this gene is ytbE [H]
Identifier: 226224855
GI number: 226224855
Start: 2342459
End: 2343343
Strand: Reverse
Name: ytbE [H]
Synonym: Lm4b_02274
Alternate gene names: 226224855
Gene position: 2343343-2342459 (Counterclockwise)
Preceding gene: 226224861
Following gene: 226224854
Centisome position: 80.45
GC content: 38.98
Gene sequence:
>885_bases TTGACAAAAACATTACAAGACAGAATGATACTACCGGGGAATGAGACAATTCCTTATATTGGACTTGGTGTATTTCAAGT AACAGAACAAGAATTTATCGCTGGTGCTGTGGAAAAGGCAATCGAAGTAGGTTATCGTTTGTTTGATACAGCGGCAGTTT ATAATAATGAAGCGATTGTTGGGCAAGCAATTGCTAGTAGCGCAGTCTCACGAGAAGAATTATTTATTAGTTCGAAAGTG TGGAACGGAGACCTTGGCTTTGATGAAACGTTATTTGCTTTTGAGCGAACACTTCGGAATTTGAAGTTGGATTATTTGGA TTTGTATTTAATTCATTGGCCTGTAGCTGGGAAATACCGTGATTCATGGCGAGCGATGGAGCGGCTTCATGACGAAAAAT TGATTAAATCTATTGGAGTTGCGAATTTCAAGCAACATCATTTAAGTGACTTATTGGTTGCTGCAAATGAAAAACCAGTT TTAAATCAAGTGGAAACGCATCCACTGTTACCGCAAAATGACCTTCGTAAGTATTTGGCGGAACAGAATATCGCGCACGC TGCCTGGTCACCGCTGGCTAAAGGAATATTAATGCAAAATCCGGTGATTACAGAAATTGCGAAAAAACATCAAGCATCTG TAGATCAAGTGATTTTACAATGGCATTTGAACCGCAATACGATTATTTTTCCGAAGTCAATTACTTCTAGTCGGATTGAG GAGAATTCACGTTTGTCCTATTTCCAACTAGATGCCATTGATATGGAAAAAATTGATCGCTTAGAAACGGGGAAACGTGT TGGACCAGATCCAGATGATTTAGAATACTTTTTAAGTAGTATTGAACGGGAACGCGCTTATTTATCAGGTGAGAATGCGG AATGA
Upstream 100 bases:
>100_bases TTTCGGTATACTGGTTTTAAAATATAAATTTGCGAAAATAGTGTATAATTCATTTAAGAGAAAAAGTTCACAAAACAGTT TTCGTGAGGAGGGTTTCGTT
Downstream 100 bases:
>100_bases CAGATATTCAAATGGTATTCCGCGCGAATCGTTCTTTAATAGATGCTCCGCCAATGGAAGCTTACATGAAAAATCAATTT ACTTTTTTGGGAATTAGAGC
Product: oxidoreductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 294; Mature: 293
Protein sequence:
>294_residues MTKTLQDRMILPGNETIPYIGLGVFQVTEQEFIAGAVEKAIEVGYRLFDTAAVYNNEAIVGQAIASSAVSREELFISSKV WNGDLGFDETLFAFERTLRNLKLDYLDLYLIHWPVAGKYRDSWRAMERLHDEKLIKSIGVANFKQHHLSDLLVAANEKPV LNQVETHPLLPQNDLRKYLAEQNIAHAAWSPLAKGILMQNPVITEIAKKHQASVDQVILQWHLNRNTIIFPKSITSSRIE ENSRLSYFQLDAIDMEKIDRLETGKRVGPDPDDLEYFLSSIERERAYLSGENAE
Sequences:
>Translated_294_residues MTKTLQDRMILPGNETIPYIGLGVFQVTEQEFIAGAVEKAIEVGYRLFDTAAVYNNEAIVGQAIASSAVSREELFISSKV WNGDLGFDETLFAFERTLRNLKLDYLDLYLIHWPVAGKYRDSWRAMERLHDEKLIKSIGVANFKQHHLSDLLVAANEKPV LNQVETHPLLPQNDLRKYLAEQNIAHAAWSPLAKGILMQNPVITEIAKKHQASVDQVILQWHLNRNTIIFPKSITSSRIE ENSRLSYFQLDAIDMEKIDRLETGKRVGPDPDDLEYFLSSIERERAYLSGENAE >Mature_293_residues TKTLQDRMILPGNETIPYIGLGVFQVTEQEFIAGAVEKAIEVGYRLFDTAAVYNNEAIVGQAIASSAVSREELFISSKVW NGDLGFDETLFAFERTLRNLKLDYLDLYLIHWPVAGKYRDSWRAMERLHDEKLIKSIGVANFKQHHLSDLLVAANEKPVL NQVETHPLLPQNDLRKYLAEQNIAHAAWSPLAKGILMQNPVITEIAKKHQASVDQVILQWHLNRNTIIFPKSITSSRIEE NSRLSYFQLDAIDMEKIDRLETGKRVGPDPDDLEYFLSSIERERAYLSGENAE
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI223468663, Length=280, Percent_Identity=40, Blast_Score=180, Evalue=1e-45, Organism=Homo sapiens, GI24497577, Length=293, Percent_Identity=33.4470989761092, Blast_Score=178, Evalue=5e-45, Organism=Homo sapiens, GI5174391, Length=293, Percent_Identity=33.4470989761092, Blast_Score=178, Evalue=5e-45, Organism=Homo sapiens, GI291291012, Length=264, Percent_Identity=39.3939393939394, Blast_Score=166, Evalue=3e-41, Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=34.5394736842105, Blast_Score=162, Evalue=4e-40, Organism=Homo sapiens, GI310109922, Length=270, Percent_Identity=36.2962962962963, Blast_Score=161, Evalue=7e-40, Organism=Homo sapiens, GI45446745, Length=290, Percent_Identity=34.4827586206897, Blast_Score=158, Evalue=5e-39, Organism=Homo sapiens, GI4503285, Length=290, Percent_Identity=34.4827586206897, Blast_Score=158, Evalue=5e-39, Organism=Homo sapiens, GI310109920, Length=290, Percent_Identity=34.1379310344828, Blast_Score=158, Evalue=7e-39, Organism=Homo sapiens, GI5453543, Length=289, Percent_Identity=33.9100346020761, Blast_Score=156, Evalue=2e-38, Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=32.7759197324415, Blast_Score=153, Evalue=2e-37, Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=33.2214765100671, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI300116273, Length=279, Percent_Identity=32.9749103942652, Blast_Score=147, Evalue=8e-36, Organism=Homo sapiens, GI24497583, Length=285, Percent_Identity=32.9824561403509, Blast_Score=147, Evalue=1e-35, Organism=Homo sapiens, GI4502049, Length=287, Percent_Identity=36.9337979094077, Blast_Score=144, Evalue=7e-35, Organism=Homo sapiens, GI300116271, Length=277, Percent_Identity=30.3249097472924, Blast_Score=119, Evalue=4e-27, Organism=Homo sapiens, GI310109924, Length=155, Percent_Identity=32.9032258064516, Blast_Score=87, Evalue=3e-17, Organism=Homo sapiens, GI207028673, Length=108, Percent_Identity=43.5185185185185, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI310109926, Length=108, Percent_Identity=42.5925925925926, Blast_Score=83, Evalue=2e-16, Organism=Escherichia coli, GI87082198, Length=265, Percent_Identity=45.6603773584906, Blast_Score=231, Evalue=5e-62, Organism=Escherichia coli, GI1786400, Length=259, Percent_Identity=35.1351351351351, Blast_Score=152, Evalue=2e-38, Organism=Escherichia coli, GI1788081, Length=277, Percent_Identity=29.6028880866426, Blast_Score=119, Evalue=2e-28, Organism=Caenorhabditis elegans, GI71998625, Length=266, Percent_Identity=36.4661654135338, Blast_Score=173, Evalue=1e-43, Organism=Caenorhabditis elegans, GI17561298, Length=267, Percent_Identity=35.5805243445693, Blast_Score=163, Evalue=8e-41, Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=33.8403041825095, Blast_Score=154, Evalue=6e-38, Organism=Caenorhabditis elegans, GI17564128, Length=301, Percent_Identity=30.8970099667774, Blast_Score=149, Evalue=2e-36, Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=35.3333333333333, Blast_Score=146, Evalue=1e-35, Organism=Caenorhabditis elegans, GI17537077, Length=290, Percent_Identity=35.1724137931034, Blast_Score=144, Evalue=7e-35, Organism=Caenorhabditis elegans, GI17550248, Length=287, Percent_Identity=32.7526132404181, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17538386, Length=270, Percent_Identity=32.962962962963, Blast_Score=136, Evalue=1e-32, Organism=Caenorhabditis elegans, GI17562292, Length=250, Percent_Identity=31.2, Blast_Score=130, Evalue=9e-31, Organism=Caenorhabditis elegans, GI17561300, Length=267, Percent_Identity=31.0861423220974, Blast_Score=127, Evalue=8e-30, Organism=Caenorhabditis elegans, GI17537079, Length=303, Percent_Identity=29.3729372937294, Blast_Score=122, Evalue=3e-28, Organism=Caenorhabditis elegans, GI17566692, Length=300, Percent_Identity=28, Blast_Score=112, Evalue=2e-25, Organism=Saccharomyces cerevisiae, GI6324694, Length=316, Percent_Identity=36.3924050632911, Blast_Score=176, Evalue=4e-45, Organism=Saccharomyces cerevisiae, GI6320576, Length=278, Percent_Identity=33.0935251798561, Blast_Score=152, Evalue=5e-38, Organism=Saccharomyces cerevisiae, GI6321896, Length=305, Percent_Identity=33.7704918032787, Blast_Score=150, Evalue=2e-37, Organism=Saccharomyces cerevisiae, GI6322556, Length=254, Percent_Identity=34.6456692913386, Blast_Score=148, Evalue=1e-36, Organism=Saccharomyces cerevisiae, GI6319625, Length=276, Percent_Identity=30.0724637681159, Blast_Score=137, Evalue=2e-33, Organism=Saccharomyces cerevisiae, GI6320079, Length=232, Percent_Identity=29.7413793103448, Blast_Score=93, Evalue=4e-20, Organism=Drosophila melanogaster, GI24657054, Length=282, Percent_Identity=39.0070921985816, Blast_Score=180, Evalue=1e-45, Organism=Drosophila melanogaster, GI24662789, Length=295, Percent_Identity=35.5932203389831, Blast_Score=177, Evalue=9e-45, Organism=Drosophila melanogaster, GI24663317, Length=286, Percent_Identity=34.965034965035, Blast_Score=161, Evalue=5e-40, Organism=Drosophila melanogaster, GI21356425, Length=291, Percent_Identity=35.3951890034364, Blast_Score=159, Evalue=3e-39, Organism=Drosophila melanogaster, GI20129731, Length=283, Percent_Identity=34.6289752650177, Blast_Score=157, Evalue=1e-38, Organism=Drosophila melanogaster, GI24644950, Length=311, Percent_Identity=33.1189710610932, Blast_Score=150, Evalue=1e-36, Organism=Drosophila melanogaster, GI24662785, Length=295, Percent_Identity=37.9661016949153, Blast_Score=147, Evalue=6e-36, Organism=Drosophila melanogaster, GI221378297, Length=335, Percent_Identity=30.7462686567164, Blast_Score=142, Evalue=2e-34, Organism=Drosophila melanogaster, GI24662781, Length=292, Percent_Identity=37.6712328767123, Blast_Score=140, Evalue=8e-34, Organism=Drosophila melanogaster, GI45553081, Length=284, Percent_Identity=29.9295774647887, Blast_Score=126, Evalue=2e-29, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=29.4573643410853, Blast_Score=112, Evalue=2e-25,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 33512; Mature: 33380
Theoretical pI: Translated: 5.25; Mature: 5.25
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 1.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTKTLQDRMILPGNETIPYIGLGVFQVTEQEFIAGAVEKAIEVGYRLFDTAAVYNNEAIV CCCCCCCCEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH GQAIASSAVSREELFISSKVWNGDLGFDETLFAFERTLRNLKLDYLDLYLIHWPVAGKYR HHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHEEEEEEECCCCCCHH DSWRAMERLHDEKLIKSIGVANFKQHHLSDLLVAANEKPVLNQVETHPLLPQNDLRKYLA HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHH EQNIAHAAWSPLAKGILMQNPVITEIAKKHQASVDQVILQWHLNRNTIIFPKSITSSRIE HCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCHHHHHC ENSRLSYFQLDAIDMEKIDRLETGKRVGPDPDDLEYFLSSIERERAYLSGENAE CCCCCCEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC >Mature Secondary Structure TKTLQDRMILPGNETIPYIGLGVFQVTEQEFIAGAVEKAIEVGYRLFDTAAVYNNEAIV CCCCCCCEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH GQAIASSAVSREELFISSKVWNGDLGFDETLFAFERTLRNLKLDYLDLYLIHWPVAGKYR HHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHEEEEEEECCCCCCHH DSWRAMERLHDEKLIKSIGVANFKQHHLSDLLVAANEKPVLNQVETHPLLPQNDLRKYLA HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHH EQNIAHAAWSPLAKGILMQNPVITEIAKKHQASVDQVILQWHLNRNTIIFPKSITSSRIE HCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCHHHHHC ENSRLSYFQLDAIDMEKIDRLETGKRVGPDPDDLEYFLSSIERERAYLSGENAE CCCCCCEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]