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The map label for this gene is fabH [H]

Identifier: 226224810

GI number: 226224810

Start: 2296933

End: 2297871

Strand: Reverse

Name: fabH [H]

Synonym: Lm4b_02229

Alternate gene names: 226224810

Gene position: 2297871-2296933 (Counterclockwise)

Preceding gene: 226224811

Following gene: 226224809

Centisome position: 78.89

GC content: 39.83

Gene sequence:

>939_bases
ATGAACGCAGGAATTTTAGGAGTAGGTAAATACGTACCTGAAAAAATAGTAACTAACTTTGATTTAGAAAAAATTATGGA
TACATCTGATGAGTGGATTAGAACTCGAACTGGTATTGAGGAAAGAAGAATTGCTCGTGATGACGAATATACGCATGATT
TAGCATATGAAGCAGCAAAGGTAGCCATTAAGAATGCTGGTCTTACACCAGATGATATTGACTTGTTTATCGTTGCAACT
GTTACACAAGAAGCGACATTTCCTTCAGTTGCTAATATTATCCAAGACCGCTTAGGAGCAAAAAACGCTGCTGGTATGGA
CGTTGAGGCAGCTTGTGCTGGTTTCACTTTTGGAGTAGTGACTGCAGCACAATTCATTAAAACAGGTGCATATAAAAATA
TCGTGGTTGTCGGTGCGGATAAATTATCTAAAATCACTAACTGGGATGATCGCACAACAGCAGTATTATTCGGTGATGGA
GCAGGTGCTGTAGTTATGGGGCCAGTTTCTGATGATCATGGTTTACTTTCATTTGACTTAGGTTCAGATGGATCAGGTGG
TAAATACTTGAATTTAGATGAAAATAAAAAGATTTATATGAACGGTCGTGAAGTATTCCGCTTTGCAGTTCGCCAAATGG
GAGAAGCTTCACTACGAGTACTTGAACGTGCTGGTCTTGAGAAAGAAGACTTGGACTTACTAATTCCTCACCAAGCAAAT
ATTCGTATTATGGAAGCTTCTCGTGAGCGTTTGAATTTACCAGAAGAAAAACTGATGAAAACAGTACACAAATATGGTAA
TACTTCGTCCTCTTCAATCGCACTTGCGCTCGTTGATGCAGTGGAAGAAGGACGTATTAAAGATAATGATAACGTTCTGC
TCGTAGGTTTTGGCGGCGGACTAACATGGGGCGCCCTAATCATTCGTTGGGGTAAGTAA

Upstream 100 bases:

>100_bases
CTTAATTGATAGTTCTCTGTTAAAATTAGCACCAGGTCATAAAAATAACCAGGAGAAAATTTATTTTCACCCTGATGTAG
TTTGATATGGAGGAGAACAC

Downstream 100 bases:

>100_bases
GCAGTAAATTTAAAAAGGAAAGTTGCCCTAACGATTATTTTAGTTAGGACAACTTTCCTTTATTTATGTTATAATGGAAC
AGGCTTTTGGTTTATTTGTT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNAGILGVGKYVPEKIVTNFDLEKIMDTSDEWIRTRTGIEERRIARDDEYTHDLAYEAAKVAIKNAGLTPDDIDLFIVAT
VTQEATFPSVANIIQDRLGAKNAAGMDVEAACAGFTFGVVTAAQFIKTGAYKNIVVVGADKLSKITNWDDRTTAVLFGDG
AGAVVMGPVSDDHGLLSFDLGSDGSGGKYLNLDENKKIYMNGREVFRFAVRQMGEASLRVLERAGLEKEDLDLLIPHQAN
IRIMEASRERLNLPEEKLMKTVHKYGNTSSSSIALALVDAVEEGRIKDNDNVLLVGFGGGLTWGALIIRWGK

Sequences:

>Translated_312_residues
MNAGILGVGKYVPEKIVTNFDLEKIMDTSDEWIRTRTGIEERRIARDDEYTHDLAYEAAKVAIKNAGLTPDDIDLFIVAT
VTQEATFPSVANIIQDRLGAKNAAGMDVEAACAGFTFGVVTAAQFIKTGAYKNIVVVGADKLSKITNWDDRTTAVLFGDG
AGAVVMGPVSDDHGLLSFDLGSDGSGGKYLNLDENKKIYMNGREVFRFAVRQMGEASLRVLERAGLEKEDLDLLIPHQAN
IRIMEASRERLNLPEEKLMKTVHKYGNTSSSSIALALVDAVEEGRIKDNDNVLLVGFGGGLTWGALIIRWGK
>Mature_312_residues
MNAGILGVGKYVPEKIVTNFDLEKIMDTSDEWIRTRTGIEERRIARDDEYTHDLAYEAAKVAIKNAGLTPDDIDLFIVAT
VTQEATFPSVANIIQDRLGAKNAAGMDVEAACAGFTFGVVTAAQFIKTGAYKNIVVVGADKLSKITNWDDRTTAVLFGDG
AGAVVMGPVSDDHGLLSFDLGSDGSGGKYLNLDENKKIYMNGREVFRFAVRQMGEASLRVLERAGLEKEDLDLLIPHQAN
IRIMEASRERLNLPEEKLMKTVHKYGNTSSSSIALALVDAVEEGRIKDNDNVLLVGFGGGLTWGALIIRWGK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=318, Percent_Identity=44.3396226415094, Blast_Score=267, Evalue=6e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 33971; Mature: 33971

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAGILGVGKYVPEKIVTNFDLEKIMDTSDEWIRTRTGIEERRIARDDEYTHDLAYEAAK
CCCCEEECCHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHH
VAIKNAGLTPDDIDLFIVATVTQEATFPSVANIIQDRLGAKNAAGMDVEAACAGFTFGVV
HHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHH
TAAQFIKTGAYKNIVVVGADKLSKITNWDDRTTAVLFGDGAGAVVMGPVSDDHGLLSFDL
HHHHHHHCCCCCEEEEECCHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCCEEEEEC
GSDGSGGKYLNLDENKKIYMNGREVFRFAVRQMGEASLRVLERAGLEKEDLDLLIPHQAN
CCCCCCCEEEECCCCCEEEECHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCEECCCCCC
IRIMEASRERLNLPEEKLMKTVHKYGNTSSSSIALALVDAVEEGRIKDNDNVLLVGFGGG
EEEEECCHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCCCCCCCCEEEEEECCC
LTWGALIIRWGK
CCEEEEEEEECC
>Mature Secondary Structure
MNAGILGVGKYVPEKIVTNFDLEKIMDTSDEWIRTRTGIEERRIARDDEYTHDLAYEAAK
CCCCEEECCHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHH
VAIKNAGLTPDDIDLFIVATVTQEATFPSVANIIQDRLGAKNAAGMDVEAACAGFTFGVV
HHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHH
TAAQFIKTGAYKNIVVVGADKLSKITNWDDRTTAVLFGDGAGAVVMGPVSDDHGLLSFDL
HHHHHHHCCCCCEEEEECCHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCCEEEEEC
GSDGSGGKYLNLDENKKIYMNGREVFRFAVRQMGEASLRVLERAGLEKEDLDLLIPHQAN
CCCCCCCEEEECCCCCEEEECHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCEECCCCCC
IRIMEASRERLNLPEEKLMKTVHKYGNTSSSSIALALVDAVEEGRIKDNDNVLLVGFGGG
EEEEECCHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCCCCCCCCEEEEEECCC
LTWGALIIRWGK
CCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]