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The map label for this gene is tpx

Identifier: 226224184

GI number: 226224184

Start: 1609203

End: 1609700

Strand: Reverse

Name: tpx

Synonym: Lm4b_01594

Alternate gene names: 226224184

Gene position: 1609700-1609203 (Counterclockwise)

Preceding gene: 226224185

Following gene: 226224183

Centisome position: 55.27

GC content: 40.16

Gene sequence:

>498_bases
ATGACTCAAGTAACATTTAAACATAATCCAGTTACACTCGTAGGTACCGAAAGAAAAGTTGGCGACAAAGCGCCGAACTT
CACAGTGGTGAATAGAGATTTAGAAGAAGTAACATTGCACGATTATGACGGGAAAGTGAGACTTATCAGCGTTGTTCCTT
CCATTGATACAAGTGTTTGTTCCACACAAACGCGTAAATTTAATGAAGAAGCAAGCAATTTAGATAATACAGTTGTCTTA
ACTATCTCCGTTGATTTACCATTTGCTCAAAAGAAATGGTGTGCCGCAGAAGGTTTACCAAATGCGATTACATTATCTGA
TCACCGCGATCTTTCTTTTGGCGAAGCATACGGTGTAGTCATGAAAGAACTTCGCTTACTAGCTCGTTCTGTTTTTGTGG
TAAATGCAGCAGGGGAAATCGTCTACACGGAAGTAGTTCCAGAAGGTAGCGATCATCCGAATTATGAAGCAGCGATAGAA
GCAGCCAAAAAAGCTTAA

Upstream 100 bases:

>100_bases
AGAACTAGATGAAAAATGGGTAAATGGAGCAAAAAAATAGCTTATAGCAAACTTCTTCTTTAAAATGGAATAGAAGCGTC
CATTAAAGGAGGAAGAAAAA

Downstream 100 bases:

>100_bases
ATCTTAAAAGCCTTCCTTTAGTTAGGAGGGCTTTTTTCTGTATTACTACTAAAAATAAACTGTACTAATGATAATGAACT
ATTTCCAATGAGAATTTCAT

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MTQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVCSTQTRKFNEEASNLDNTVVL
TISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVVMKELRLLARSVFVVNAAGEIVYTEVVPEGSDHPNYEAAIE
AAKKA

Sequences:

>Translated_165_residues
MTQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVCSTQTRKFNEEASNLDNTVVL
TISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVVMKELRLLARSVFVVNAAGEIVYTEVVPEGSDHPNYEAAIE
AAKKA
>Mature_164_residues
TQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVCSTQTRKFNEEASNLDNTVVLT
ISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVVMKELRLLARSVFVVNAAGEIVYTEVVPEGSDHPNYEAAIEA
AKKA

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=167, Percent_Identity=46.1077844311377, Blast_Score=151, Evalue=2e-38,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18092; Mature: 17960

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVC
CCEEEECCCCEEEEECCCCCCCCCCCEEEEECCHHHEEEECCCCCEEEEEEECCCCCHHH
STQTRKFNEEASNLDNTVVLTISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVV
HHHHHHHCCHHCCCCCEEEEEEEECCCCCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHH
MKELRLLARSVFVVNAAGEIVYTEVVPEGSDHPNYEAAIEAAKKA
HHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVC
CEEEECCCCEEEEECCCCCCCCCCCEEEEECCHHHEEEECCCCCEEEEEEECCCCCHHH
STQTRKFNEEASNLDNTVVLTISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVV
HHHHHHHCCHHCCCCCEEEEEEEECCCCCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHH
MKELRLLARSVFVVNAAGEIVYTEVVPEGSDHPNYEAAIEAAKKA
HHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]