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The map label for this gene is ald2 [H]

Identifier: 226224180

GI number: 226224180

Start: 1604930

End: 1606042

Strand: Reverse

Name: ald2 [H]

Synonym: Lm4b_01590

Alternate gene names: 226224180

Gene position: 1606042-1604930 (Counterclockwise)

Preceding gene: 226224182

Following gene: 226224178

Centisome position: 55.14

GC content: 40.7

Gene sequence:

>1113_bases
ATGTTAGTCGGCGTACCAAAAGAAATTAAAAATAACGAGAATAGGGTGGCAATGACTCCGGCAAGTGTTTTTTCATACGT
AAATGCAGGTCATACTGTATACGTGGAAAAAGATGCGGGCATTGGCTCTAATTATCAAGACGCTGATTTTGTGCAAGCGG
GGGCAAAAATTGTTGAAACAGCTAAAGAAGCTTGGGATGTAGATATGGTTGTAAAAGTAAAAGAACCGATTGCATCAGAG
TATACATACTTTAAAGAAGGACTATTACTTTTCACATATTTACATTTGGCAAATGAACCAACGCTTGCGAAAGCTTTGAT
GGAGAGTAAAGTAAATAGTGTGGCGTATGAAACAGTAGAACTTGCAGACCATACGTTGCCATTACTTTCGCCAATGAGTG
AAGTTGCTGGGCGAATGGCAGCTCAGATTGGCGCACAATTTTTACAAAGAACGAATGGTGGTATGGGTGTCTTGCTTGGT
GGGGTGCCGGGTGTAGAGAAAAGTGAAGTGGTTATTATTGGTGGCGGAATCGCTGGAACAAATGCAGCGAAAATTGCAGC
TGGTTTAGGTGCCAACGTGACCATTCTTGATATGAATTTGAAACGATTGCGCGAACTGGACGATATTTTTGGCAATCAAG
TCCAAACGTTAATGTCGAATGATTTTAATATTGAAACAGCTGTGAAAAAAGCTGATTTGGTTATTGGAGCAGTATTAATT
CCAGGAGCAAAAGCGCCCAAACTCGTCAAAGAGCATGTAATTAAACAAATGATTCCGGGATCTGTCCTTGTAGATATCGC
GATTGACCAAGGAGGGATTTTTGAAACAACAGATCACGTTTCCACACACGATAATCCAACCTACGAAAAATATGGTGTAC
TTCATTATGCTGTTGCAAATATGCCAGGTGCAGTACCGCGGACGTCCACTTTGGCGCTTACTAATGCCACTTTACCATTT
GGATTGAAACTGGCTAATCAAGGTTTAGAAGCAGCCGTGCAAAATGACCCATTCTTACTTCGTGGATTAAATACATACCA
AGGTCACATTACGTACAAGGCTGTTGCAGATTCACTTGATTTACCCTATACGGATAGCAAAGAATTAATTTAA

Upstream 100 bases:

>100_bases
CAGTTAGTTAATTTTTTACAACTTAGGTATATTGTGTTAGCATGGGGGTGTAGAAAATCTTTTATAGTCTATTATACCTA
TATCAAGGAGAGTGATTTAG

Downstream 100 bases:

>100_bases
TAAAAAAAGCGAACTTTCTCAAAGGAAAGTTCGCTTTTCTTGTTAGTCGATTACTTGTAAAGTTTTTGGGAATTCCGTTA
ATACTTGCACGCCGTCTTTT

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MLVGVPKEIKNNENRVAMTPASVFSYVNAGHTVYVEKDAGIGSNYQDADFVQAGAKIVETAKEAWDVDMVVKVKEPIASE
YTYFKEGLLLFTYLHLANEPTLAKALMESKVNSVAYETVELADHTLPLLSPMSEVAGRMAAQIGAQFLQRTNGGMGVLLG
GVPGVEKSEVVIIGGGIAGTNAAKIAAGLGANVTILDMNLKRLRELDDIFGNQVQTLMSNDFNIETAVKKADLVIGAVLI
PGAKAPKLVKEHVIKQMIPGSVLVDIAIDQGGIFETTDHVSTHDNPTYEKYGVLHYAVANMPGAVPRTSTLALTNATLPF
GLKLANQGLEAAVQNDPFLLRGLNTYQGHITYKAVADSLDLPYTDSKELI

Sequences:

>Translated_370_residues
MLVGVPKEIKNNENRVAMTPASVFSYVNAGHTVYVEKDAGIGSNYQDADFVQAGAKIVETAKEAWDVDMVVKVKEPIASE
YTYFKEGLLLFTYLHLANEPTLAKALMESKVNSVAYETVELADHTLPLLSPMSEVAGRMAAQIGAQFLQRTNGGMGVLLG
GVPGVEKSEVVIIGGGIAGTNAAKIAAGLGANVTILDMNLKRLRELDDIFGNQVQTLMSNDFNIETAVKKADLVIGAVLI
PGAKAPKLVKEHVIKQMIPGSVLVDIAIDQGGIFETTDHVSTHDNPTYEKYGVLHYAVANMPGAVPRTSTLALTNATLPF
GLKLANQGLEAAVQNDPFLLRGLNTYQGHITYKAVADSLDLPYTDSKELI
>Mature_370_residues
MLVGVPKEIKNNENRVAMTPASVFSYVNAGHTVYVEKDAGIGSNYQDADFVQAGAKIVETAKEAWDVDMVVKVKEPIASE
YTYFKEGLLLFTYLHLANEPTLAKALMESKVNSVAYETVELADHTLPLLSPMSEVAGRMAAQIGAQFLQRTNGGMGVLLG
GVPGVEKSEVVIIGGGIAGTNAAKIAAGLGANVTILDMNLKRLRELDDIFGNQVQTLMSNDFNIETAVKKADLVIGAVLI
PGAKAPKLVKEHVIKQMIPGSVLVDIAIDQGGIFETTDHVSTHDNPTYEKYGVLHYAVANMPGAVPRTSTLALTNATLPF
GLKLANQGLEAAVQNDPFLLRGLNTYQGHITYKAVADSLDLPYTDSKELI

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=347, Percent_Identity=31.9884726224784, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI122939153, Length=347, Percent_Identity=31.9884726224784, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1787887, Length=382, Percent_Identity=31.151832460733, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17550456, Length=345, Percent_Identity=30.4347826086957, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39597; Mature: 39597

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVGVPKEIKNNENRVAMTPASVFSYVNAGHTVYVEKDAGIGSNYQDADFVQAGAKIVET
CCCCCCHHHCCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
AKEAWDVDMVVKVKEPIASEYTYFKEGLLLFTYLHLANEPTLAKALMESKVNSVAYETVE
HHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LADHTLPLLSPMSEVAGRMAAQIGAQFLQRTNGGMGVLLGGVPGVEKSEVVIIGGGIAGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECCCCCC
NAAKIAAGLGANVTILDMNLKRLRELDDIFGNQVQTLMSNDFNIETAVKKADLVIGAVLI
CHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEEEE
PGAKAPKLVKEHVIKQMIPGSVLVDIAIDQGGIFETTDHVSTHDNPTYEKYGVLHYAVAN
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEECCCCCCCCCCCCHHHHHHHEEHHHC
MPGAVPRTSTLALTNATLPFGLKLANQGLEAAVQNDPFLLRGLNTYQGHITYKAVADSLD
CCCCCCCCCEEEEECCCCCCCHHHHCCCHHHHHCCCCEEEEECCCCCCEEEEEEHHCCCC
LPYTDSKELI
CCCCCCCCCC
>Mature Secondary Structure
MLVGVPKEIKNNENRVAMTPASVFSYVNAGHTVYVEKDAGIGSNYQDADFVQAGAKIVET
CCCCCCHHHCCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
AKEAWDVDMVVKVKEPIASEYTYFKEGLLLFTYLHLANEPTLAKALMESKVNSVAYETVE
HHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LADHTLPLLSPMSEVAGRMAAQIGAQFLQRTNGGMGVLLGGVPGVEKSEVVIIGGGIAGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECCCCCC
NAAKIAAGLGANVTILDMNLKRLRELDDIFGNQVQTLMSNDFNIETAVKKADLVIGAVLI
CHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEEEE
PGAKAPKLVKEHVIKQMIPGSVLVDIAIDQGGIFETTDHVSTHDNPTYEKYGVLHYAVAN
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEECCCCCCCCCCCCHHHHHHHEEHHHC
MPGAVPRTSTLALTNATLPFGLKLANQGLEAAVQNDPFLLRGLNTYQGHITYKAVADSLD
CCCCCCCCCEEEEECCCCCCCHHHHCCCHHHHHCCCCEEEEECCCCCCEEEEEEHHCCCC
LPYTDSKELI
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA