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The map label for this gene is mntH [H]

Identifier: 226224025

GI number: 226224025

Start: 1439008

End: 1440354

Strand: Reverse

Name: mntH [H]

Synonym: Lm4b_01433

Alternate gene names: 226224025

Gene position: 1440354-1439008 (Counterclockwise)

Preceding gene: 226224026

Following gene: 226224024

Centisome position: 49.45

GC content: 37.05

Gene sequence:

>1347_bases
ATGAAAAAGGATAAAACAGAACGTACAAAACAAAGCTGGAGAAAAGCACAGAATGCTCCCAGCTTAAGCGAAGTAAATAA
TTCCGTAGCTATTCCTAAAAACGCAAAATTTTTCCGTAAATTATTTGCCTTTATGGGGCCAGGTGCACTTATTGCGGTCG
GCTATGTCGATCCAGGGAACTGGGCAACTTCTATTGCCGGCGGGTCAGAATTTGGTTACACATTGTTATCCGTTATTTTA
ATTTCTAATATTCTAGCCGTTTTATTACAATCACTTGCATCAAAATTAGGCATTGTCACCGGTCGCGATTTAGCCCAAGC
TTCAAGTGATCACTTTTCTAAACCATTTGGATTCGTTCTTTGGATTTTAGCTGAATTAGCGATTATAGCAACAGATATCG
CAGAAGTCATCGGTAGTGCGATTGCGCTTAATTTACTATTTGGGATTCCATTAATTTGGGGAGTTTGTATTACTGCATTA
GATATTTTTCTCGTATTATTTTTACAACATAAAGGTTTCCGCTACATAGAAGTTATTGTTATTACTTTAATGGTTACGAT
TCTTGTATGTTTTGGTGCGGAAATGGTGATGTCTCATCCTGATATGCAAGCAATAGCAAAAGGTTTTATTCCACAATCAG
AAATTGTTACTAATCCAGCTATGCTTTATATTGCACTTGGTATTCTTGGGGCAACAGTGATGCCACATAATTTATATTTG
CATTCATCTATTGTTCAAACCAGACAATACGCTCGAACAAAAGAAGGGAAGAAAGAAGCGATTCGTTTTTCCTTTATCGA
TTCCACTTTTTCTTTAACGATTGCATTATTAATCAATGCATCGATTTTAATTTTAGCGGCTGCCGCTTTTTATACGACCG
GTCAGCATAATGTCGCTGGTATTGAGGATGCTTACAAATTACTCAATCCAACACTTGGAAGCAGTATCGCCAGCACTGTT
TTTGCAGTAGCATTACTCGCATCAGGGCAAAATTCTACTTTAACAGGAACATTAGCTGGTCAAATCGTCATGGAAGGTTT
CCTTAATATCCGTTTAAAACCAGTAGTGCGTCGTTTGTTAACACGTGTACTTGCAATCGTTCCAGCTGTTATTATCACAG
CACTTTACGGGGCAAATGGTATCAATGAACTACTCATTTTTAGCCAAGTTATTCTATCAATGCAATTATCGTTCGCAGTT
ATCCCATTAGTTATGTTCACAAGTGATAAACAAAAGATGGGCGAATTCGTCAATCCAACATGGTTAAAAATCATTTCTTG
GGCTGTCGCCATTTTTATTGCAGTCTTAAACATCTACTTGTTATTTTATACTTTGACGTCATTATAA

Upstream 100 bases:

>100_bases
ACACAACCTATCATTTCTATAAAACGGTTGTGTTTTTCGTTTGACAAAGAATGTTTCCCGTAGTAAACTTTTTATCATAA
ACGAAAGAAGGTCAGGGAGC

Downstream 100 bases:

>100_bases
ATAAGGGAAGAAGACAATAATTATATTATGTAAACAATTAAAAATAATTTTCTCATTTCTTTCCCTCGAAATTTTCATCT
TTATACTATATAATTGAATT

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKKDKTERTKQSWRKAQNAPSLSEVNNSVAIPKNAKFFRKLFAFMGPGALIAVGYVDPGNWATSIAGGSEFGYTLLSVIL
ISNILAVLLQSLASKLGIVTGRDLAQASSDHFSKPFGFVLWILAELAIIATDIAEVIGSAIALNLLFGIPLIWGVCITAL
DIFLVLFLQHKGFRYIEVIVITLMVTILVCFGAEMVMSHPDMQAIAKGFIPQSEIVTNPAMLYIALGILGATVMPHNLYL
HSSIVQTRQYARTKEGKKEAIRFSFIDSTFSLTIALLINASILILAAAAFYTTGQHNVAGIEDAYKLLNPTLGSSIASTV
FAVALLASGQNSTLTGTLAGQIVMEGFLNIRLKPVVRRLLTRVLAIVPAVIITALYGANGINELLIFSQVILSMQLSFAV
IPLVMFTSDKQKMGEFVNPTWLKIISWAVAIFIAVLNIYLLFYTLTSL

Sequences:

>Translated_448_residues
MKKDKTERTKQSWRKAQNAPSLSEVNNSVAIPKNAKFFRKLFAFMGPGALIAVGYVDPGNWATSIAGGSEFGYTLLSVIL
ISNILAVLLQSLASKLGIVTGRDLAQASSDHFSKPFGFVLWILAELAIIATDIAEVIGSAIALNLLFGIPLIWGVCITAL
DIFLVLFLQHKGFRYIEVIVITLMVTILVCFGAEMVMSHPDMQAIAKGFIPQSEIVTNPAMLYIALGILGATVMPHNLYL
HSSIVQTRQYARTKEGKKEAIRFSFIDSTFSLTIALLINASILILAAAAFYTTGQHNVAGIEDAYKLLNPTLGSSIASTV
FAVALLASGQNSTLTGTLAGQIVMEGFLNIRLKPVVRRLLTRVLAIVPAVIITALYGANGINELLIFSQVILSMQLSFAV
IPLVMFTSDKQKMGEFVNPTWLKIISWAVAIFIAVLNIYLLFYTLTSL
>Mature_448_residues
MKKDKTERTKQSWRKAQNAPSLSEVNNSVAIPKNAKFFRKLFAFMGPGALIAVGYVDPGNWATSIAGGSEFGYTLLSVIL
ISNILAVLLQSLASKLGIVTGRDLAQASSDHFSKPFGFVLWILAELAIIATDIAEVIGSAIALNLLFGIPLIWGVCITAL
DIFLVLFLQHKGFRYIEVIVITLMVTILVCFGAEMVMSHPDMQAIAKGFIPQSEIVTNPAMLYIALGILGATVMPHNLYL
HSSIVQTRQYARTKEGKKEAIRFSFIDSTFSLTIALLINASILILAAAAFYTTGQHNVAGIEDAYKLLNPTLGSSIASTV
FAVALLASGQNSTLTGTLAGQIVMEGFLNIRLKPVVRRLLTRVLAIVPAVIITALYGANGINELLIFSQVILSMQLSFAV
IPLVMFTSDKQKMGEFVNPTWLKIISWAVAIFIAVLNIYLLFYTLTSL

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=465, Percent_Identity=36.3440860215054, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI295293167, Length=447, Percent_Identity=36.4653243847875, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI295293171, Length=467, Percent_Identity=35.5460385438972, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI295293169, Length=467, Percent_Identity=35.5460385438972, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI295293178, Length=467, Percent_Identity=35.5460385438972, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI295293175, Length=467, Percent_Identity=35.5460385438972, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI295293173, Length=467, Percent_Identity=35.5460385438972, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI10835169, Length=467, Percent_Identity=35.5460385438972, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1788736, Length=411, Percent_Identity=38.9294403892944, Blast_Score=282, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71999499, Length=468, Percent_Identity=35.4700854700855, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17569473, Length=411, Percent_Identity=35.2798053527981, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI193210616, Length=477, Percent_Identity=31.6561844863732, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71993856, Length=327, Percent_Identity=32.1100917431193, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323062, Length=398, Percent_Identity=43.9698492462312, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6324450, Length=420, Percent_Identity=36.1904761904762, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6321841, Length=416, Percent_Identity=42.0673076923077, Blast_Score=266, Evalue=6e-72,
Organism=Drosophila melanogaster, GI24648607, Length=453, Percent_Identity=36.4238410596026, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI281362176, Length=453, Percent_Identity=36.4238410596026, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24648609, Length=453, Percent_Identity=36.4238410596026, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI45553443, Length=430, Percent_Identity=36.9767441860465, Blast_Score=254, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 48623; Mature: 48623

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDKTERTKQSWRKAQNAPSLSEVNNSVAIPKNAKFFRKLFAFMGPGALIAVGYVDPGN
CCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCC
WATSIAGGSEFGYTLLSVILISNILAVLLQSLASKLGIVTGRDLAQASSDHFSKPFGFVL
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHCCCCHHHHHH
WILAELAIIATDIAEVIGSAIALNLLFGIPLIWGVCITALDIFLVLFLQHKGFRYIEVIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ITLMVTILVCFGAEMVMSHPDMQAIAKGFIPQSEIVTNPAMLYIALGILGATVMPHNLYL
HHHHHHHHHHHCHHHHHCCCCHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCCCHHHH
HSSIVQTRQYARTKEGKKEAIRFSFIDSTFSLTIALLINASILILAAAAFYTTGQHNVAG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IEDAYKLLNPTLGSSIASTVFAVALLASGQNSTLTGTLAGQIVMEGFLNIRLKPVVRRLL
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHH
TRVLAIVPAVIITALYGANGINELLIFSQVILSMQLSFAVIPLVMFTSDKQKMGEFVNPT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHH
WLKIISWAVAIFIAVLNIYLLFYTLTSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKDKTERTKQSWRKAQNAPSLSEVNNSVAIPKNAKFFRKLFAFMGPGALIAVGYVDPGN
CCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCC
WATSIAGGSEFGYTLLSVILISNILAVLLQSLASKLGIVTGRDLAQASSDHFSKPFGFVL
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHCCCCHHHHHH
WILAELAIIATDIAEVIGSAIALNLLFGIPLIWGVCITALDIFLVLFLQHKGFRYIEVIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ITLMVTILVCFGAEMVMSHPDMQAIAKGFIPQSEIVTNPAMLYIALGILGATVMPHNLYL
HHHHHHHHHHHCHHHHHCCCCHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCCCHHHH
HSSIVQTRQYARTKEGKKEAIRFSFIDSTFSLTIALLINASILILAAAAFYTTGQHNVAG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IEDAYKLLNPTLGSSIASTVFAVALLASGQNSTLTGTLAGQIVMEGFLNIRLKPVVRRLL
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHH
TRVLAIVPAVIITALYGANGINELLIFSQVILSMQLSFAVIPLVMFTSDKQKMGEFVNPT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHH
WLKIISWAVAIFIAVLNIYLLFYTLTSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]