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The map label for this gene is accC1 [H]

Identifier: 226223958

GI number: 226223958

Start: 1364907

End: 1366271

Strand: Direct

Name: accC1 [H]

Synonym: Lm4b_01365

Alternate gene names: 226223958

Gene position: 1364907-1366271 (Clockwise)

Preceding gene: 226223957

Following gene: 226223959

Centisome position: 46.86

GC content: 40.07

Gene sequence:

>1365_bases
ATGATTAAAAAAGTACTGGTAGCGAACCGTGGAGAAATCGCTGTCCGTATCATTCGCGCTGCAAAAGAACTTGGAGTGGA
GACAGTGGCGATTTATTCGGAAGCAGATAAAGAAGCGCTACATATTCAGCTGGCGGATGAAGCTTATTGTGTAGGTCCCG
CAGCAACAAAAGATAGTTATTTAAATATGTCCAACATTATTAGTCTTGCAGTTTTAACGAACTGTGATGCTATTCATCCT
GGCTATGGTTTCTTAGCCGAAAATGCAGATTTCGCGGAGTTATGCGAAGACTGTAATATTACTTTTATCGGACCAAGTGC
TTCCGCTATTTCGCAAATGGGAACAAAAGATGTAGCCCGCGAAACGATGCGTAAAGCAGGTGTTCCAATTGTTCCTGGTT
CACAAGGAATCGTTAAGGATGTAGAAGATGGCAAAAAAATCGCTAAGAAAATCGGTTATCCGGTTATCATTAAAGCAACA
GCTGGCGGTGGCGGTAAAGGTATCCGTGTAGCAGAAAATGAAGAAAAATTAATTTCTGGCATTCAAACTACCCAACAAGA
AGCCGAAGCCGCATTTGGTGATCCTGGCGTTTACTTAGAAAAGTATATTCAAGATTTCCGCCATGTAGAAATTCAAGTGC
TTGCTGATAACCATGGTAACGTTATTCATTTAGGAGAACGTGATTGTAGTATTCAACGTCGCTTACAAAAGCTAATTGAA
GAATCACCATCACCTGCCATTGATGAAAAAACTCGCCAAAAAATGGGGAAAGCTGCTGTTAAAGCTGCCAAAGCCGTGAA
TTATTCTGGCGCAGGAACGATTGAATTCATTTTCGATCACCATGAAAATAATTTTTACTTTATGGAAATGAATACGCGTA
TCCAAGTAGAACACCCGGTAACCGAGCTTGTTACTGGTGTTGATTTAGTGAAACAACAATTTCTAGTTGCTTCTGGGGAA
GAACTACAAATTAAACAAGCAGATGTGAAATTAACAGGTTGGGCGATGGAATGTCGAATTAACGCTGAAAATCCAGAGAA
AAACTTTATGCCAGCTCCAGGTGAAATTAAATTTTATCTTCCTCCAGGTGGCTTAGGTGTTCGAATTGACTCAGCAGCAT
ATCCAAACTACAAAATCCCACCATACTATGATTCGATGATTGCCAAAGTAATCTGTTATGCGGAAACACGGGAAGAAGTG
ATTCAAAAAATGAAACGTGCGTTGTCCGAATTTGCCATTGATGGCATTCCTTCAACGATTCCGTTCCATTTACGTGTATT
AGATAATGATGTGTTTTTATCAGGCGACTTCAATACCAAATTCTTGGAGCAAAACGATGTAATGAATCTTTCTAAGGAGG
GCTAA

Upstream 100 bases:

>100_bases
ATCGACGGAGAAATCGCAGAAATTCTTGTTTCAAGTGGCGAATTAGTCGAATTTGGACAACCACTATTCAAAGTTAGAAA
AAAATAAGGGGTCGAAAAAC

Downstream 100 bases:

>100_bases
ATAATGGCTTATACAAAAGATTTGCGTAAACAAAATGATGCACCGCTTGGCAAAATTGAGATTGCACCTGAAGTAATCGG
CGTAATTGCTGGACTTGCCG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MIKKVLVANRGEIAVRIIRAAKELGVETVAIYSEADKEALHIQLADEAYCVGPAATKDSYLNMSNIISLAVLTNCDAIHP
GYGFLAENADFAELCEDCNITFIGPSASAISQMGTKDVARETMRKAGVPIVPGSQGIVKDVEDGKKIAKKIGYPVIIKAT
AGGGGKGIRVAENEEKLISGIQTTQQEAEAAFGDPGVYLEKYIQDFRHVEIQVLADNHGNVIHLGERDCSIQRRLQKLIE
ESPSPAIDEKTRQKMGKAAVKAAKAVNYSGAGTIEFIFDHHENNFYFMEMNTRIQVEHPVTELVTGVDLVKQQFLVASGE
ELQIKQADVKLTGWAMECRINAENPEKNFMPAPGEIKFYLPPGGLGVRIDSAAYPNYKIPPYYDSMIAKVICYAETREEV
IQKMKRALSEFAIDGIPSTIPFHLRVLDNDVFLSGDFNTKFLEQNDVMNLSKEG

Sequences:

>Translated_454_residues
MIKKVLVANRGEIAVRIIRAAKELGVETVAIYSEADKEALHIQLADEAYCVGPAATKDSYLNMSNIISLAVLTNCDAIHP
GYGFLAENADFAELCEDCNITFIGPSASAISQMGTKDVARETMRKAGVPIVPGSQGIVKDVEDGKKIAKKIGYPVIIKAT
AGGGGKGIRVAENEEKLISGIQTTQQEAEAAFGDPGVYLEKYIQDFRHVEIQVLADNHGNVIHLGERDCSIQRRLQKLIE
ESPSPAIDEKTRQKMGKAAVKAAKAVNYSGAGTIEFIFDHHENNFYFMEMNTRIQVEHPVTELVTGVDLVKQQFLVASGE
ELQIKQADVKLTGWAMECRINAENPEKNFMPAPGEIKFYLPPGGLGVRIDSAAYPNYKIPPYYDSMIAKVICYAETREEV
IQKMKRALSEFAIDGIPSTIPFHLRVLDNDVFLSGDFNTKFLEQNDVMNLSKEG
>Mature_454_residues
MIKKVLVANRGEIAVRIIRAAKELGVETVAIYSEADKEALHIQLADEAYCVGPAATKDSYLNMSNIISLAVLTNCDAIHP
GYGFLAENADFAELCEDCNITFIGPSASAISQMGTKDVARETMRKAGVPIVPGSQGIVKDVEDGKKIAKKIGYPVIIKAT
AGGGGKGIRVAENEEKLISGIQTTQQEAEAAFGDPGVYLEKYIQDFRHVEIQVLADNHGNVIHLGERDCSIQRRLQKLIE
ESPSPAIDEKTRQKMGKAAVKAAKAVNYSGAGTIEFIFDHHENNFYFMEMNTRIQVEHPVTELVTGVDLVKQQFLVASGE
ELQIKQADVKLTGWAMECRINAENPEKNFMPAPGEIKFYLPPGGLGVRIDSAAYPNYKIPPYYDSMIAKVICYAETREEV
IQKMKRALSEFAIDGIPSTIPFHLRVLDNDVFLSGDFNTKFLEQNDVMNLSKEG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=47.6404494382022, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=50.3401360544218, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=50.3401360544218, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=50.3401360544218, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=44.7661469933185, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=44.7661469933185, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=44.7661469933185, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=30.3326810176125, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=30.3326810176125, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=30.3326810176125, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=30.3326810176125, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=30.3326810176125, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=29.9412915851272, Blast_Score=229, Evalue=3e-60,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=53.4831460674157, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.5113122171946, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=46.031746031746, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=45.1111111111111, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133931226, Length=503, Percent_Identity=31.8091451292247, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI71997168, Length=521, Percent_Identity=29.7504798464491, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=521, Percent_Identity=29.7504798464491, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI193204318, Length=333, Percent_Identity=21.021021021021, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=44.0449438202247, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=44.5190156599553, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=45.8612975391499, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=31.3953488372093, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323863, Length=468, Percent_Identity=31.4102564102564, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=45.43429844098, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=46.7706013363029, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=44.5255474452555, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=30.0990099009901, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=30.0990099009901, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=30.0990099009901, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=30.0990099009901, Blast_Score=229, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49920; Mature: 49920

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVLVANRGEIAVRIIRAAKELGVETVAIYSEADKEALHIQLADEAYCVGPAATKDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCCCC
LNMSNIISLAVLTNCDAIHPGYGFLAENADFAELCEDCNITFIGPSASAISQMGTKDVAR
CCHHHHHEEEEEECCCCCCCCCCEEECCCCHHHHHHCCCEEEECCCHHHHHHCCHHHHHH
ETMRKAGVPIVPGSQGIVKDVEDGKKIAKKIGYPVIIKATAGGGGKGIRVAENEEKLISG
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHHH
IQTTQQEAEAAFGDPGVYLEKYIQDFRHVEIQVLADNHGNVIHLGERDCSIQRRLQKLIE
HHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPAIDEKTRQKMGKAAVKAAKAVNYSGAGTIEFIFDHHENNFYFMEMNTRIQVEHPV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCEEEECCCH
TELVTGVDLVKQQFLVASGEELQIKQADVKLTGWAMECRINAENPEKNFMPAPGEIKFYL
HHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEE
PPGGLGVRIDSAAYPNYKIPPYYDSMIAKVICYAETREEVIQKMKRALSEFAIDGIPSTI
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PFHLRVLDNDVFLSGDFNTKFLEQNDVMNLSKEG
CEEEEEECCEEEEECCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MIKKVLVANRGEIAVRIIRAAKELGVETVAIYSEADKEALHIQLADEAYCVGPAATKDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCCCC
LNMSNIISLAVLTNCDAIHPGYGFLAENADFAELCEDCNITFIGPSASAISQMGTKDVAR
CCHHHHHEEEEEECCCCCCCCCCEEECCCCHHHHHHCCCEEEECCCHHHHHHCCHHHHHH
ETMRKAGVPIVPGSQGIVKDVEDGKKIAKKIGYPVIIKATAGGGGKGIRVAENEEKLISG
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHHH
IQTTQQEAEAAFGDPGVYLEKYIQDFRHVEIQVLADNHGNVIHLGERDCSIQRRLQKLIE
HHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPAIDEKTRQKMGKAAVKAAKAVNYSGAGTIEFIFDHHENNFYFMEMNTRIQVEHPV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCEEEECCCH
TELVTGVDLVKQQFLVASGEELQIKQADVKLTGWAMECRINAENPEKNFMPAPGEIKFYL
HHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEE
PPGGLGVRIDSAAYPNYKIPPYYDSMIAKVICYAETREEVIQKMKRALSEFAIDGIPSTI
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PFHLRVLDNDVFLSGDFNTKFLEQNDVMNLSKEG
CEEEEEECCEEEEECCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]