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The map label for this gene is uppS [H]

Identifier: 226223916

GI number: 226223916

Start: 1324787

End: 1325545

Strand: Direct

Name: uppS [H]

Synonym: Lm4b_01323

Alternate gene names: 226223916

Gene position: 1324787-1325545 (Clockwise)

Preceding gene: 226223915

Following gene: 226223917

Centisome position: 45.48

GC content: 38.87

Gene sequence:

>759_bases
ATGTTTAAAAAGCTATTTCGACAAGATGAAAATATATTAAATAGTGAACTTGCAGAAGATTTACCTATCCCGCGCCATGT
AGCTATTATCATGGATGGGAATGGAAGGTGGGCGAAGAAACGTTTTTTGCCGCGCATTGCTGGGCATAAAGAAGGTATGG
ATGTCGTAAAGCGAGTGACACGTTATGCTAATGCAATTGGCATCGATGTTTTAACGCTTTATGCATTTTCAACTGAAAAT
TGGAAGAGACCTACAGATGAAGTGGATTTTTTAATGAAACTTCCTGTAGAATTTTTTGACTCTTTTGTACCAGAGTTGAT
TGAAGAAAATGTTCGTGTTAATGTGATGGGGTACAGAGAAAATTTACCTAATCATACGATGCGTGCCGTAGAGAAAGCCA
TAGCTGATACAGCGCATTGCACAGGGCTTACGCTTAACTTTGCACTTAACTACGGTGGACGTTCAGAAATTATTACTGCT
GCCAAAGAAGCGATGAAAGAATTAGAGCTTGAAGGGAAAAGTGCAGATGATCTGACAGAAGAAAAATTAAATGATCATTT
GATGAGTAGCGGTTTGGGTGATCCTGACTTGTTGATTCGGACGAGTGGGGAGCTTAGATTAAGTAATTTTATGCTTTGGC
AACTGGCGTATAGTGAGTTTTATTTTACGGATACACATTGGCCTGATTTTTCAAAAGAAGATTTTTTACAGGCAATTATT
GAATATCAAAACCGGTCACGTCGTTTTGGAGGGCTCTAG

Upstream 100 bases:

>100_bases
CTCATCTGTTCACATGGAATTTTTAGTACATTAATTGATTCTTTTTTGTTATTATAGGTATAGACATGCTCTAAGAAGTG
TATCAATTGGAGGATTTATG

Downstream 100 bases:

>100_bases
GGAGGAAAAAAGATTGAAAACGAGAATTATTACTGCAGTTGTTGCGCTTATATTTTTTATTCCATTCGTTGTCTACGGAG
GAATTCCATTTGAACTATTA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MFKKLFRQDENILNSELAEDLPIPRHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVTRYANAIGIDVLTLYAFSTEN
WKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRENLPNHTMRAVEKAIADTAHCTGLTLNFALNYGGRSEIITA
AKEAMKELELEGKSADDLTEEKLNDHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTDTHWPDFSKEDFLQAII
EYQNRSRRFGGL

Sequences:

>Translated_252_residues
MFKKLFRQDENILNSELAEDLPIPRHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVTRYANAIGIDVLTLYAFSTEN
WKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRENLPNHTMRAVEKAIADTAHCTGLTLNFALNYGGRSEIITA
AKEAMKELELEGKSADDLTEEKLNDHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTDTHWPDFSKEDFLQAII
EYQNRSRRFGGL
>Mature_252_residues
MFKKLFRQDENILNSELAEDLPIPRHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVTRYANAIGIDVLTLYAFSTEN
WKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRENLPNHTMRAVEKAIADTAHCTGLTLNFALNYGGRSEIITA
AKEAMKELELEGKSADDLTEEKLNDHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTDTHWPDFSKEDFLQAII
EYQNRSRRFGGL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=36, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=36, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1786371, Length=237, Percent_Identity=48.5232067510549, Blast_Score=221, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=37.9310344827586, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=231, Percent_Identity=33.7662337662338, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=237, Percent_Identity=31.6455696202532, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=37.5, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29016; Mature: 29016

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKLFRQDENILNSELAEDLPIPRHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVT
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHH
RYANAIGIDVLTLYAFSTENWKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRE
HHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCC
NLPNHTMRAVEKAIADTAHCTGLTLNFALNYGGRSEIITAAKEAMKELELEGKSADDLTE
CCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
EKLNDHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTDTHWPDFSKEDFLQAII
HHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHH
EYQNRSRRFGGL
HHHHHCCCCCCC
>Mature Secondary Structure
MFKKLFRQDENILNSELAEDLPIPRHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVT
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHH
RYANAIGIDVLTLYAFSTENWKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRE
HHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCC
NLPNHTMRAVEKAIADTAHCTGLTLNFALNYGGRSEIITAAKEAMKELELEGKSADDLTE
CCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
EKLNDHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTDTHWPDFSKEDFLQAII
HHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHH
EYQNRSRRFGGL
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]