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The map label for this gene is pyrH

Identifier: 226223914

GI number: 226223914

Start: 1323271

End: 1323999

Strand: Direct

Name: pyrH

Synonym: Lm4b_01321

Alternate gene names: 226223914

Gene position: 1323271-1323999 (Clockwise)

Preceding gene: 226223908

Following gene: 226223915

Centisome position: 45.43

GC content: 41.56

Gene sequence:

>729_bases
ATGGATACCCCAGATTATAAACGAGTTGTATTAAAATTAAGCGGTGAAGCACTTGCCGGAAATGATGGCTTTGGAATTAA
TCCGAGCGTGGTCAATTTGATTTCTGCTCAAATCAAAGAAGTAGTAGAACTAGGAGTAGAGGTAGCTATCGTTGTTGGCG
GCGGGAATATCTGGCGCGGTAAACTTGGTAGTGAAATGGGAATGGACCGTGCAGCGGCCGACCAAATGGGTATGCTTGCG
ACTATCATGAATTCCTTGTCTTTACAAGATTCCCTTGAAAACATTGGAGTAGCAACGCGTGTGCAAACTTCCATTGATAT
GCGCCAAATTGCTGAGCCGTACATTCGTCGAAAAGCGATTCGCCACCTTGAAAAAGGTCGCGTCGTTATTTTTGCAGGTG
GAACAGGTAACCCATACTTCTCCACAGATACAGCGGCAGCACTTAGAGCGGCTGAAATCGAAGCAGATGTTATCTTAATG
GCGAAAAATAATGTAGATGGTGTCTACAATGCTGATCCAAAACTAGATGAAAATGCGAAAAAATACGAAGAGTTATCTTA
CCTTGATGTGATTAAAGAAGGATTGGAAGTTATGGATACAACTGCGTCCTCTCTAAGTATGGACAACGATATTCCATTAA
TCGTCTTCTCGTTTACAGAACAAGGCAATAATATTAAACGTGTTATTTTAGGTGAAAAAATCGGGACTACTGTTAGGGGG
AAAAAATAA

Upstream 100 bases:

>100_bases
GTAGAAAACACTTTTGTAATAGCCAGCTTTTTAGTAGAATAGATAATGGTGGATGGAAAACTCTTCTATCTATGAATAGA
ATATGAAAATGGAGGCTATT

Downstream 100 bases:

>100_bases
TGAGTAAAGAAGTATTATCGAAATCCAAAGAAAAAATGGAAAAAGCAGAACAAGCATTAACAAGACAATTAGGTACAATC
CGCGCTGGTCGTGCGAATGC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MDTPDYKRVVLKLSGEALAGNDGFGINPSVVNLISAQIKEVVELGVEVAIVVGGGNIWRGKLGSEMGMDRAAADQMGMLA
TIMNSLSLQDSLENIGVATRVQTSIDMRQIAEPYIRRKAIRHLEKGRVVIFAGGTGNPYFSTDTAAALRAAEIEADVILM
AKNNVDGVYNADPKLDENAKKYEELSYLDVIKEGLEVMDTTASSLSMDNDIPLIVFSFTEQGNNIKRVILGEKIGTTVRG
KK

Sequences:

>Translated_242_residues
MDTPDYKRVVLKLSGEALAGNDGFGINPSVVNLISAQIKEVVELGVEVAIVVGGGNIWRGKLGSEMGMDRAAADQMGMLA
TIMNSLSLQDSLENIGVATRVQTSIDMRQIAEPYIRRKAIRHLEKGRVVIFAGGTGNPYFSTDTAAALRAAEIEADVILM
AKNNVDGVYNADPKLDENAKKYEELSYLDVIKEGLEVMDTTASSLSMDNDIPLIVFSFTEQGNNIKRVILGEKIGTTVRG
KK
>Mature_242_residues
MDTPDYKRVVLKLSGEALAGNDGFGINPSVVNLISAQIKEVVELGVEVAIVVGGGNIWRGKLGSEMGMDRAAADQMGMLA
TIMNSLSLQDSLENIGVATRVQTSIDMRQIAEPYIRRKAIRHLEKGRVVIFAGGTGNPYFSTDTAAALRAAEIEADVILM
AKNNVDGVYNADPKLDENAKKYEELSYLDVIKEGLEVMDTTASSLSMDNDIPLIVFSFTEQGNNIKRVILGEKIGTTVRG
KK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=47.2340425531915, Blast_Score=227, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_LISIN (P65928)

Other databases:

- EMBL:   AL596168
- PIR:   AE1601
- RefSeq:   NP_470686.1
- ProteinModelPortal:   P65928
- SMR:   P65928
- GeneID:   1129942
- GenomeReviews:   AL592022_GR
- KEGG:   lin:lin1350
- GenoList:   LIN1350
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   LINN272626:LIN1350-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26166; Mature: 26166

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 163-163 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTPDYKRVVLKLSGEALAGNDGFGINPSVVNLISAQIKEVVELGVEVAIVVGGGNIWRG
CCCCCCEEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEC
KLGSEMGMDRAAADQMGMLATIMNSLSLQDSLENIGVATRVQTSIDMRQIAEPYIRRKAI
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFAGGTGNPYFSTDTAAALRAAEIEADVILMAKNNVDGVYNADPKLDENAK
HHHHCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCCHHH
KYEELSYLDVIKEGLEVMDTTASSLSMDNDIPLIVFSFTEQGNNIKRVILGEKIGTTVRG
HHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCEEEEEECCHHCCCCCC
KK
CC
>Mature Secondary Structure
MDTPDYKRVVLKLSGEALAGNDGFGINPSVVNLISAQIKEVVELGVEVAIVVGGGNIWRG
CCCCCCEEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEC
KLGSEMGMDRAAADQMGMLATIMNSLSLQDSLENIGVATRVQTSIDMRQIAEPYIRRKAI
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFAGGTGNPYFSTDTAAALRAAEIEADVILMAKNNVDGVYNADPKLDENAK
HHHHCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCCHHH
KYEELSYLDVIKEGLEVMDTTASSLSMDNDIPLIVFSFTEQGNNIKRVILGEKIGTTVRG
HHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCEEEEEECCHHCCCCCC
KK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669