BacMap

Definition	Listeria monocytogenes Clip81459, complete genome.
Accession	NC_012488
Length	2,912,690

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The map label for this gene is kduD [H]

Identifier: 226222970

GI number: 226222970

Start: 373904

End: 374668

Strand: Reverse

Name: kduD [H]

Synonym: Lm4b_00362

Alternate gene names: 226222970

Gene position: 374668-373904 (Counterclockwise)

Preceding gene: 226222971

Following gene: 226222969

Centisome position: 12.86

GC content: 40.78

Gene sequence:

>765_bases
ATGACTTTTAAAGGTTTTGATAAAGATTTTAACATTACAGACAAAGTAGCCGTGGTAACTGGGGCAGCAAGCGGGATTGG
TAAAGCAATGGCAGAACTTTTTTCCGAAAAAGGCGCTTATGTTGTCTTGCTTGATATTAAAGAAGATGTAAAAGATGTCG
CAGCAAAAATCAATCCATCAAGAACGCTAGCACTTCAAGTCGATATTACGAAGAAAGAAAACATCGAAAAAGTCGTTGCC
GAAATCAAAAAAGTCTATCCAAAAATCGATATTTTAGCCAATTCAGCTGGTGTCGCACTTCTCGAAAAAGCAGAAGATTT
ACCAGAAGAGTACTGGGATAAAACAATGGAACTGAACTTAAAAGGTTCGTTCCTAATGGCGCAAATTATCGGTCGCGAAA
TGATTGCAACTGGCGGCGGTAAAATCGTTAATATGGCCTCTCAAGCTTCTGTTATTGCACTTGATAAACACGTTGCCTAC
TGTGCGAGTAAAGCAGCGATTGTTTCTATGACACAAGTGCTAGCAATGGAATGGGCGCCTTACAACATTAATGTCAATGC
GATTTCCCCAACCGTTATCTTGACGGAACTAGGCAAAAAAGCTTGGGCAGGTCAAGTCGGCGAAGACATGAAAAAATTAA
TTCCAGCCGGTAGATTTGGTTATCCAGAAGAAGTTGCCGCATGCGCCCTCTTTTTAGTAAGTGACGCAGCGAGCCTTATT
ACTGGGGAAAACCTAATTATCGACGGTGGTTATACGATTAAATAA

Upstream 100 bases:

>100_bases
GGATAGCGACTTTTCGGGCGGACGCTCCCAAGCAAAAGTAGATTTAATGGAAGAAATCGACCAAAAAAATAGATAAAAAA
TTTATTGGAGGTAATGAAAA

Downstream 100 bases:

>100_bases
AGTATTCAGCTTTAAAGTTCAGCTGAGAGAATGGAGCGAGTAAATAATGAAATTTTTCTTGGACACAGCAAGCGTATCGG
AAATAAAACGAATTAGCGAA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTFKGFDKDFNITDKVAVVTGAASGIGKAMAELFSEKGAYVVLLDIKEDVKDVAAKINPSRTLALQVDITKKENIEKVVA
EIKKVYPKIDILANSAGVALLEKAEDLPEEYWDKTMELNLKGSFLMAQIIGREMIATGGGKIVNMASQASVIALDKHVAY
CASKAAIVSMTQVLAMEWAPYNINVNAISPTVILTELGKKAWAGQVGEDMKKLIPAGRFGYPEEVAACALFLVSDAASLI
TGENLIIDGGYTIK

Sequences:

>Translated_254_residues
MTFKGFDKDFNITDKVAVVTGAASGIGKAMAELFSEKGAYVVLLDIKEDVKDVAAKINPSRTLALQVDITKKENIEKVVA
EIKKVYPKIDILANSAGVALLEKAEDLPEEYWDKTMELNLKGSFLMAQIIGREMIATGGGKIVNMASQASVIALDKHVAY
CASKAAIVSMTQVLAMEWAPYNINVNAISPTVILTELGKKAWAGQVGEDMKKLIPAGRFGYPEEVAACALFLVSDAASLI
TGENLIIDGGYTIK
>Mature_253_residues
TFKGFDKDFNITDKVAVVTGAASGIGKAMAELFSEKGAYVVLLDIKEDVKDVAAKINPSRTLALQVDITKKENIEKVVAE
IKKVYPKIDILANSAGVALLEKAEDLPEEYWDKTMELNLKGSFLMAQIIGREMIATGGGKIVNMASQASVIALDKHVAYC
ASKAAIVSMTQVLAMEWAPYNINVNAISPTVILTELGKKAWAGQVGEDMKKLIPAGRFGYPEEVAACALFLVSDAASLIT
GENLIIDGGYTIK

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=236, Percent_Identity=34.7457627118644, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=34.5098039215686, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=32.2834645669291, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI126723750, Length=258, Percent_Identity=32.1705426356589, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=32.6530612244898, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=28.968253968254, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI10190704, Length=245, Percent_Identity=31.4285714285714, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI66933014, Length=226, Percent_Identity=30.9734513274336, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI5031737, Length=263, Percent_Identity=31.1787072243346, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI59889578, Length=225, Percent_Identity=29.7777777777778, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI31542939, Length=210, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4758504, Length=251, Percent_Identity=31.0756972111554, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI126723191, Length=205, Percent_Identity=33.6585365853659, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI224922801, Length=172, Percent_Identity=33.7209302325581, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI33667109, Length=218, Percent_Identity=31.651376146789, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4503817, Length=182, Percent_Identity=34.0659340659341, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI4503301, Length=243, Percent_Identity=31.2757201646091, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI83715985, Length=247, Percent_Identity=29.9595141700405, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40807363, Length=171, Percent_Identity=29.2397660818713, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI7706318, Length=212, Percent_Identity=29.2452830188679, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4504505, Length=232, Percent_Identity=25.8620689655172, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=30.1507537688442, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI225579078, Length=207, Percent_Identity=28.9855072463768, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI142976729, Length=177, Percent_Identity=28.8135593220339, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI302344755, Length=130, Percent_Identity=35.3846153846154, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI157739938, Length=190, Percent_Identity=27.8947368421053, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI25282469, Length=198, Percent_Identity=24.7474747474747, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI210032110, Length=173, Percent_Identity=28.3236994219653, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI109715829, Length=251, Percent_Identity=26.2948207171315, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=35.6, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=34.9206349206349, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=30.9803921568627, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=30.7053941908714, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=29.5719844357977, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=30.7377049180328, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1786812, Length=245, Percent_Identity=31.4285714285714, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=31.9838056680162, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=27.734375, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1787526, Length=239, Percent_Identity=27.6150627615063, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=31.25, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=27.8008298755187, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787820, Length=180, Percent_Identity=26.1111111111111, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787545, Length=257, Percent_Identity=25.6809338521401, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=258, Percent_Identity=33.7209302325581, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=32.6530612244898, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17561402, Length=247, Percent_Identity=34.0080971659919, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=30.6818181818182, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25147288, Length=243, Percent_Identity=30.0411522633745, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=32.4, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=30.5882352941176, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=30.7392996108949, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17536025, Length=256, Percent_Identity=32.03125, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=28.4615384615385, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=29.3893129770992, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=31.2, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=26.9961977186312, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=29.1666666666667, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=32.2709163346614, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=30.3030303030303, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=29.2307692307692, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=29.2134831460674, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=27.8625954198473, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=28.3524904214559, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=28.6259541984733, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=27.3764258555133, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17561272, Length=253, Percent_Identity=31.6205533596838, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17565030, Length=276, Percent_Identity=31.1594202898551, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=32.2916666666667, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=27.6515151515151, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17563726, Length=257, Percent_Identity=27.6264591439689, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=269, Percent_Identity=28.996282527881, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=26.4150943396226, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193203117, Length=189, Percent_Identity=30.6878306878307, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193203115, Length=172, Percent_Identity=31.3953488372093, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=27.1698113207547, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997099, Length=211, Percent_Identity=27.9620853080569, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=186, Percent_Identity=27.4193548387097, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71997402, Length=242, Percent_Identity=29.7520661157025, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17570069, Length=240, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=170, Percent_Identity=27.6470588235294, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=29.2307692307692, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324126, Length=246, Percent_Identity=28.8617886178862, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322067, Length=188, Percent_Identity=30.3191489361702, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=199, Percent_Identity=28.643216080402, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=31.9672131147541, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=33.739837398374, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=34.1463414634146, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=32.9218106995885, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=33.7301587301587, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=32.8, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=30.2788844621514, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644337, Length=255, Percent_Identity=33.7254901960784, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=29.8804780876494, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358495, Length=199, Percent_Identity=29.6482412060301, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=30.1587301587302, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI22024069, Length=216, Percent_Identity=31.0185185185185, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28573296, Length=223, Percent_Identity=26.9058295964126, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640492, Length=213, Percent_Identity=25.3521126760563, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281364892, Length=201, Percent_Identity=24.3781094527363, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24586328, Length=209, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076371, Length=211, Percent_Identity=27.4881516587678, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356301, Length=192, Percent_Identity=27.6041666666667, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24584752, Length=191, Percent_Identity=31.413612565445, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19921754, Length=211, Percent_Identity=27.0142180094787, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 27262; Mature: 27131

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFKGFDKDFNITDKVAVVTGAASGIGKAMAELFSEKGAYVVLLDIKEDVKDVAAKINPS
CCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCC
RTLALQVDITKKENIEKVVAEIKKVYPKIDILANSAGVALLEKAEDLPEEYWDKTMELNL
EEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCHHHCCCEEEEEC
KGSFLMAQIIGREMIATGGGKIVNMASQASVIALDKHVAYCASKAAIVSMTQVLAMEWAP
CCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
YNINVNAISPTVILTELGKKAWAGQVGEDMKKLIPAGRFGYPEEVAACALFLVSDAASLI
CEEEEECCCCCHHHHHHCCHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
TGENLIIDGGYTIK
CCCEEEEECCEEEC
>Mature Secondary Structure 
TFKGFDKDFNITDKVAVVTGAASGIGKAMAELFSEKGAYVVLLDIKEDVKDVAAKINPS
CCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCC
RTLALQVDITKKENIEKVVAEIKKVYPKIDILANSAGVALLEKAEDLPEEYWDKTMELNL
EEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCHHHCCCEEEEEC
KGSFLMAQIIGREMIATGGGKIVNMASQASVIALDKHVAYCASKAAIVSMTQVLAMEWAP
CCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
YNINVNAISPTVILTELGKKAWAGQVGEDMKKLIPAGRFGYPEEVAACALFLVSDAASLI
CEEEEECCCCCHHHHHHCCHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
TGENLIIDGGYTIK
CCCEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1766386 [H]