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The map label for this gene is guaB [H]

Identifier: 226222771

GI number: 226222771

Start: 137504

End: 139012

Strand: Reverse

Name: guaB [H]

Synonym: Lm4b_00136

Alternate gene names: 226222771

Gene position: 139012-137504 (Counterclockwise)

Preceding gene: 226222786

Following gene: 226222769

Centisome position: 4.77

GC content: 42.41

Gene sequence:

>1509_bases
ATGGCATTTTATTTTGAAGAACCGTCCCGCACATTTAGTGAATTTTTACTTGTCCCAGGCTACTCATCCGCTGAATGTGT
TCCAACAAATGTTAGCTTAAAAACACCAATCGTAAAATTTAAAAAAGGGGAAGAATCTGCTATCACAATGAACATTCCGC
TTGTTTCCGCAATTATGCAAGCTGTTTCTGATGATAATATGGGGATTGCGCTTGCGACAGAAGGTGGCGTATCATTCATC
TTCGGCTCCCAGTCCATCGAAAGTGAAGCTGCAATGGTTTCTCGCGTGAAAAATCATAAAGCTGGTTTCGTTATTAGTGA
TTCCAACATCAGCCCTGACAAAACACTTCAAGACATCCTTGATTTAAAAGAAAAAACGGGTCATTCTACAGTAGCAGTTA
CAGAAGACGGCACAGCGCACGGTAAATTACTTGGAATCGTGACAAGTCGCGACTACCGCGTAACGCGCATGAGCCCTGAT
GAAAAAGTAGCAGATTTCATGACTCCTTTCGAAAAATTAGTTACTGCTAACAAATCGACCACTTTAAAAGAAGCTAACAA
CATTATTTGGGACAACAAATTAAATGCCCTACCACTTGTAGACGATAACGAGCACCTAGTCCATATGGTATTCCGCAAAG
ACTATGACTCTAATAAAGAAAATAAATTAGAACTACTTGATTCCTCCAAACGTTACGTTGTTGGAGCTGGTATTAACACG
CGCGACTACGAAGAACGTGTTCCCGCTCTAGTTGAAGCTGGCGCAGATATTCTGTGTATCGATTCCTCTGAGGGTTACTC
CGAATGGCAAAAACGCACACTTGACTATGTTCGCGGTAAATACGGCGATACGGTCAAAGTTGGCGCAGGGAATGTTGTTG
ACCGCGATGGTTTCCGTTATCTTGCAGAAGCTGGCGCAGATTTCGTTAAAGTTGGCGTTGGTGGTGGTTCCATTTGTATC
ACGCGTGAACAAAAAGGTATCGGACGCGGGCAAGCAACTGCACTAATTGATGTGGCTAAAGCACGCGATGAATATTTTGA
AGAAACAGGTGTATATATTCCAATTTGTTCTGATGGTGGAATTGTTTATGACTACCACATGACGCTAGCTCTAGCAATGG
GCGCTGACTTTATCATGCTTGGTCGTTATTTCTCTCGTTTTGACGAAAGTCCTACTAATAAAGTGAATTTAAACGGCACG
TATATGAAAGAATATTGGGGTGAAGGAGCTAACCGCGCGCGCAACTGGCAACGTTATGACCTTGGCGGCGACAAGAAATT
ATCTTTTGAAGAAGGCGTAGATTCTTATGTTCCTTACGCTGGATCTTTGAAAGACAATGTTGCCATCAGCCTTAGCAAAG
TACGCTCTACTATGTGTAACTGCGGCGCGCTCAATATCCCTGAATTACAACAAAAAGCAAAAATCACCCTTGTTTCGTCC
ACTTCTATCGTAGAAGGCGGCGCGCATGATGTGGTTGTAAAAGATGCTTCAAATAATTTAATCAAATAA

Upstream 100 bases:

>100_bases
GTCCGAAAAAGCTCCCCCAATCATTGACTTTCCATCCAGTTATTGAAATAATAAAGATATTTTATAAATTCATTTAAAAA
TAGAAGAAGGAGTGGAAATA

Downstream 100 bases:

>100_bases
AATAAAATTGGTTGGTGTGAATTTGGTAAATTACCATTCTCACACCAACCAATTTTTTATTTATACATCTTACACAAAGG
AATATTTTTCTTTAATATCT

Product: inosine 5-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MAFYFEEPSRTFSEFLLVPGYSSAECVPTNVSLKTPIVKFKKGEESAITMNIPLVSAIMQAVSDDNMGIALATEGGVSFI
FGSQSIESEAAMVSRVKNHKAGFVISDSNISPDKTLQDILDLKEKTGHSTVAVTEDGTAHGKLLGIVTSRDYRVTRMSPD
EKVADFMTPFEKLVTANKSTTLKEANNIIWDNKLNALPLVDDNEHLVHMVFRKDYDSNKENKLELLDSSKRYVVGAGINT
RDYEERVPALVEAGADILCIDSSEGYSEWQKRTLDYVRGKYGDTVKVGAGNVVDRDGFRYLAEAGADFVKVGVGGGSICI
TREQKGIGRGQATALIDVAKARDEYFEETGVYIPICSDGGIVYDYHMTLALAMGADFIMLGRYFSRFDESPTNKVNLNGT
YMKEYWGEGANRARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVAISLSKVRSTMCNCGALNIPELQQKAKITLVSS
TSIVEGGAHDVVVKDASNNLIK

Sequences:

>Translated_502_residues
MAFYFEEPSRTFSEFLLVPGYSSAECVPTNVSLKTPIVKFKKGEESAITMNIPLVSAIMQAVSDDNMGIALATEGGVSFI
FGSQSIESEAAMVSRVKNHKAGFVISDSNISPDKTLQDILDLKEKTGHSTVAVTEDGTAHGKLLGIVTSRDYRVTRMSPD
EKVADFMTPFEKLVTANKSTTLKEANNIIWDNKLNALPLVDDNEHLVHMVFRKDYDSNKENKLELLDSSKRYVVGAGINT
RDYEERVPALVEAGADILCIDSSEGYSEWQKRTLDYVRGKYGDTVKVGAGNVVDRDGFRYLAEAGADFVKVGVGGGSICI
TREQKGIGRGQATALIDVAKARDEYFEETGVYIPICSDGGIVYDYHMTLALAMGADFIMLGRYFSRFDESPTNKVNLNGT
YMKEYWGEGANRARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVAISLSKVRSTMCNCGALNIPELQQKAKITLVSS
TSIVEGGAHDVVVKDASNNLIK
>Mature_501_residues
AFYFEEPSRTFSEFLLVPGYSSAECVPTNVSLKTPIVKFKKGEESAITMNIPLVSAIMQAVSDDNMGIALATEGGVSFIF
GSQSIESEAAMVSRVKNHKAGFVISDSNISPDKTLQDILDLKEKTGHSTVAVTEDGTAHGKLLGIVTSRDYRVTRMSPDE
KVADFMTPFEKLVTANKSTTLKEANNIIWDNKLNALPLVDDNEHLVHMVFRKDYDSNKENKLELLDSSKRYVVGAGINTR
DYEERVPALVEAGADILCIDSSEGYSEWQKRTLDYVRGKYGDTVKVGAGNVVDRDGFRYLAEAGADFVKVGVGGGSICIT
REQKGIGRGQATALIDVAKARDEYFEETGVYIPICSDGGIVYDYHMTLALAMGADFIMLGRYFSRFDESPTNKVNLNGTY
MKEYWGEGANRARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVAISLSKVRSTMCNCGALNIPELQQKAKITLVSST
SIVEGGAHDVVVKDASNNLIK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI34328928, Length=491, Percent_Identity=33.6048879837067, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI34328930, Length=491, Percent_Identity=33.6048879837067, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI217035146, Length=491, Percent_Identity=33.6048879837067, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI156616279, Length=491, Percent_Identity=33.6048879837067, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI217035152, Length=492, Percent_Identity=33.739837398374, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI217035148, Length=491, Percent_Identity=32.9938900203666, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI66933016, Length=493, Percent_Identity=32.4543610547667, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI217035150, Length=491, Percent_Identity=31.7718940936864, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI156104880, Length=237, Percent_Identity=32.9113924050633, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI50541956, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI50541954, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI50541952, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI50541948, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=6e-21,
Organism=Escherichia coli, GI1788855, Length=497, Percent_Identity=36.2173038229376, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1786293, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71994385, Length=510, Percent_Identity=30.7843137254902, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71994389, Length=425, Percent_Identity=33.1764705882353, Blast_Score=209, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17560440, Length=284, Percent_Identity=27.8169014084507, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323585, Length=500, Percent_Identity=32.8, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6323464, Length=501, Percent_Identity=33.7325349301397, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6322012, Length=501, Percent_Identity=33.3333333333333, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6319352, Length=355, Percent_Identity=35.7746478873239, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24641071, Length=474, Percent_Identity=34.1772151898734, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24641073, Length=474, Percent_Identity=34.1772151898734, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI28571163, Length=426, Percent_Identity=34.5070422535211, Blast_Score=207, Evalue=9e-54,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 55038; Mature: 54907

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFYFEEPSRTFSEFLLVPGYSSAECVPTNVSLKTPIVKFKKGEESAITMNIPLVSAIMQ
CCEEECCCHHHHHHEEEECCCCCCCEEECCCEECCCEEEEECCCCCEEEEECHHHHHHHH
AVSDDNMGIALATEGGVSFIFGSQSIESEAAMVSRVKNHKAGFVISDSNISPDKTLQDIL
HHCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
DLKEKTGHSTVAVTEDGTAHGKLLGIVTSRDYRVTRMSPDEKVADFMTPFEKLVTANKST
HHHHHCCCCEEEEECCCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCCC
TLKEANNIIWDNKLNALPLVDDNEHLVHMVFRKDYDSNKENKLELLDSSKRYVVGAGINT
CHHHHCCEEECCCCCCCCEECCCCCEEEEEECCCCCCCCCCEEHEECCCCCEEEECCCCC
RDYEERVPALVEAGADILCIDSSEGYSEWQKRTLDYVRGKYGDTVKVGAGNVVDRDGFRY
CCHHHHCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHH
LAEAGADFVKVGVGGGSICITREQKGIGRGQATALIDVAKARDEYFEETGVYIPICSDGG
HHHCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
IVYDYHMTLALAMGADFIMLGRYFSRFDESPTNKVNLNGTYMKEYWGEGANRARNWQRYD
EEEEHHHEEHHHHCCCHHHHHHHHHHHCCCCCCEEECCCEEHHHHHCCCCHHHCCCEEEC
LGGDKKLSFEEGVDSYVPYAGSLKDNVAISLSKVRSTMCNCGALNIPELQQKAKITLVSS
CCCCCCCCHHHCCHHHCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCHHHHCCCEEEEEEC
TSIVEGGAHDVVVKDASNNLIK
CCEECCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
AFYFEEPSRTFSEFLLVPGYSSAECVPTNVSLKTPIVKFKKGEESAITMNIPLVSAIMQ
CEEECCCHHHHHHEEEECCCCCCCEEECCCEECCCEEEEECCCCCEEEEECHHHHHHHH
AVSDDNMGIALATEGGVSFIFGSQSIESEAAMVSRVKNHKAGFVISDSNISPDKTLQDIL
HHCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
DLKEKTGHSTVAVTEDGTAHGKLLGIVTSRDYRVTRMSPDEKVADFMTPFEKLVTANKST
HHHHHCCCCEEEEECCCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCCC
TLKEANNIIWDNKLNALPLVDDNEHLVHMVFRKDYDSNKENKLELLDSSKRYVVGAGINT
CHHHHCCEEECCCCCCCCEECCCCCEEEEEECCCCCCCCCCEEHEECCCCCEEEECCCCC
RDYEERVPALVEAGADILCIDSSEGYSEWQKRTLDYVRGKYGDTVKVGAGNVVDRDGFRY
CCHHHHCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHH
LAEAGADFVKVGVGGGSICITREQKGIGRGQATALIDVAKARDEYFEETGVYIPICSDGG
HHHCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
IVYDYHMTLALAMGADFIMLGRYFSRFDESPTNKVNLNGTYMKEYWGEGANRARNWQRYD
EEEEHHHEEHHHHCCCHHHHHHHHHHHCCCCCCEEECCCEEHHHHHCCCCHHHCCCEEEC
LGGDKKLSFEEGVDSYVPYAGSLKDNVAISLSKVRSTMCNCGALNIPELQQKAKITLVSS
CCCCCCCCHHHCCHHHCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCHHHHCCCEEEEEEC
TSIVEGGAHDVVVKDASNNLIK
CCEECCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]