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The map label for this gene is murA

Identifier: 225861783

GI number: 225861783

Start: 1824190

End: 1825473

Strand: Reverse

Name: murA

Synonym: SPT_1945

Alternate gene names: 225861783

Gene position: 1825473-1824190 (Counterclockwise)

Preceding gene: 225861784

Following gene: 225861782

Centisome position: 86.43

GC content: 46.65

Gene sequence:

>1284_bases
ATGGATAAAATTGTGGTTCAAGGTGGCGATAATCGTCTGGTAGGAAGCGTGACGATCGAGGGAGCAAAAAATGCAGTCTT
ACCCTTGTTGGCAGCGACTATTCTAGCAAGTGAAGGAAAGACCGTCTTGCAGAATGTTCCGATTTTGTCGGATGTCTTTA
TTATGAATCAGGTAGTTGGTGGTTTGAATGCCAAGGTTGACTTTGATGAGGAAGCTCATCTTGTCAAGGTGGATGCTACT
GGCGACATCACTGAGGAAGCCCCTTACAAGTATGTCAGTAAGATGCGCGCCTCCATCGTTGTATTAGGGCCAATCCTTGC
CCGTGTGGGTCATGCCAAGGTATCCATGCCAGGTGGTTGTACGATTGGTAGCCGTCCTATTGATCTTCATTTGAAAGGTC
TGGAAGCTATGGGGGTTAAGATTAGTCAGACAGCTGGTTACATCGAAGCAAAGGCAGAACGCTTGCATGGTGCTCATATC
TATATGGACTTTCCAAGTGTTGGTGCAACGCAGAACTTGATGATGGCAGCGACTCTGGCTGATGGGGTGACAGTGATTGA
GAATGCTGCGCGTGAGCCTGAGATTGTTGACTTAGCCATTCTCCTTAATGAAATGGGAGCCAAGGTCAAAGGTGCTGGTA
CAGAGACTATAACCATTACTGGTGTTGAGAAACTTCATGGTACGACTCACAATGTAGTCCAGGACCGTATCGAAGCAGGA
ACCTTTATGGTAGCTGCTGCCATGACTGGTGGTGATGTCTTGATTCGAGACGCTGTCTGGGAGCACAACCGTCCCTTGAT
TGCCAAGTTACTTGAAATGGGTGTTGAAGTAATTGAAGAAGACGAAGGAATTCGTGTTCGTTCTCAACTAGAAAATCTAA
AAGCTGTTCATGTGAAAACCTTGCCCCACCCAGGATTTCCAACAGATATGCAGGCTCAATTTACAGCCTTGATGACAGTT
GCAAAAGGCGAATCAACCATGGTGGAGACAGTTTTCGAAAATCGTTTCCAACACCTAGAAGAGATGCGCCGCATGGGCTT
GCATTCTGAGATTATCCGTGATACAGCTCGTATTGTTGGTGGACAGCCTTTGCAGGGAGCAGAAGTTCTTTCAACTGACC
TTCGTGCCAGTGCAGCCTTGATTTTGACAGGTTTGGTAGCACAGGGAGAAACTGTGGTCGGTAAATTGGTTCACTTGGAT
AGAGGTTACTACGGTTTCCATGAGAAGTTGGCTCAGCTAGGTGCTAAGATTCAGCGGATTGAGGCAAGTGATGAAGATGA
ATAA

Upstream 100 bases:

>100_bases
TCATAGGCTACATCCTGAGTTCTTTCTTTATTAGCCTGTATCATTTGTGGCAAGAAGCGCTTAGAGGATTATTATAAAAT
CAAGAGTAAAGGAAACGAGT

Downstream 100 bases:

>100_bases
GAAATCAAGCTACGTAGTCAAGCGTTTACTTTTAGTCATCATAGTACTGATTTTAGGTACTCTGGCTCTAGGAATCGGTC
TAATGGTAGGTTATGGAATC

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 1; UDP-N-acetylglucosamine enolpyruvyl transferase 1; EPT 1

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQNVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDAT
GDITEEAPYKYVSKMRASIVVLGPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHI
YMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETITITGVEKLHGTTHNVVQDRIEAG
TFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVEVIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTV
AKGESTMVETVFENRFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETVVGKLVHLD
RGYYGFHEKLAQLGAKIQRIEASDEDE

Sequences:

>Translated_427_residues
MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQNVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDAT
GDITEEAPYKYVSKMRASIVVLGPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHI
YMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETITITGVEKLHGTTHNVVQDRIEAG
TFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVEVIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTV
AKGESTMVETVFENRFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETVVGKLVHLD
RGYYGFHEKLAQLGAKIQRIEASDEDE
>Mature_427_residues
MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQNVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDAT
GDITEEAPYKYVSKMRASIVVLGPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHI
YMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETITITGVEKLHGTTHNVVQDRIEAG
TFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVEVIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTV
AKGESTMVETVFENRFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETVVGKLVHLD
RGYYGFHEKLAQLGAKIQRIEASDEDE

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=422, Percent_Identity=50.4739336492891, Blast_Score=390, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA1_STRPN (Q97NQ4)

Other databases:

- EMBL:   AE005672
- PIR:   H95229
- RefSeq:   NP_346393.1
- ProteinModelPortal:   Q97NQ4
- SMR:   Q97NQ4
- EnsemblBacteria:   EBSTRT00000026314
- GeneID:   931882
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_1966
- TIGR:   SP_1966
- GeneTree:   EBGT00050000028044
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   SPNE170187-1:SP_1966-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45869; Mature: 45869

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: ACT_SITE 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQNVPILSDVFIMNQVVG
CCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHC
GLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVLGPILARVGHAKVSMPGGC
CCCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEHHHHHHCCCCEEECCCCC
TIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHIYMDFPSVGATQNLMMAATLA
CCCCCCEEEEEECCHHHCEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCHHEEEHHHH
DGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETITITGVEKLHGTTHNVVQDRIEAG
CCHHHHHHCCCCCCHHHHHHHHHHHCCEEECCCCCEEEEEEHHHHCCCHHHHHHHHHHCC
TFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVEVIEEDEGIRVRSQLENLKAVHVKT
EEEEEEEECCCCEEEECHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEE
LPHPGFPTDMQAQFTALMTVAKGESTMVETVFENRFQHLEEMRRMGLHSEIIRDTARIVG
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
GQPLQGAEVLSTDLRASAALILTGLVAQGETVVGKLVHLDRGYYGFHEKLAQLGAKIQRI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHEEC
EASDEDE
CCCCCCC
>Mature Secondary Structure
MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQNVPILSDVFIMNQVVG
CCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHC
GLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVLGPILARVGHAKVSMPGGC
CCCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEHHHHHHCCCCEEECCCCC
TIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHIYMDFPSVGATQNLMMAATLA
CCCCCCEEEEEECCHHHCEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCHHEEEHHHH
DGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETITITGVEKLHGTTHNVVQDRIEAG
CCHHHHHHCCCCCCHHHHHHHHHHHCCEEECCCCCEEEEEEHHHHCCCHHHHHHHHHHCC
TFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVEVIEEDEGIRVRSQLENLKAVHVKT
EEEEEEEECCCCEEEECHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEE
LPHPGFPTDMQAQFTALMTVAKGESTMVETVFENRFQHLEEMRRMGLHSEIIRDTARIVG
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
GQPLQGAEVLSTDLRASAALILTGLVAQGETVVGKLVHLDRGYYGFHEKLAQLGAKIQRI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHEEC
EASDEDE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916