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The map label for this gene is msrA [H]

Identifier: 225861764

GI number: 225861764

Start: 1800928

End: 1802391

Strand: Reverse

Name: msrA [H]

Synonym: SPT_1925

Alternate gene names: 225861764

Gene position: 1802391-1800928 (Counterclockwise)

Preceding gene: 225861765

Following gene: 225861745

Centisome position: 85.33

GC content: 37.77

Gene sequence:

>1464_bases
ATGGAATTAATATTAAAAGCAAAAGACATTCGTGTGGAATTCAAAGGACGCGATGTTTTAGATATAAATGAATTAGAAGT
ATATGATTATGACCGTATTGGTTTAGTAGGAGCAAATGGTGCTGGAAAAAGCACTTTACTCAGGGTACTTTTAGGAGAAT
TAACTCCCCCAGGATGTAAAATGAATCGTCTGGGTGAACTTGCCTATATTCCCCAGTTGGACGAAGTAACTCTGCAGGAG
GAAAAAGATTTTGCACTTGTAGGCAAGCTAGGTGTTGAGCAATTAAATATACAGACTATGAGCGGTGGTGAAGAAACAAG
GCTTAAAATAGCACAGGCCTTATCGGCACAGGTTCATGGTATTTTAGCGGATGAACCTACGAGCCATTTAGACCGTGAAG
GAATTGATTTTCTAATAGGACAGCTAAAATATTTTACAGGTGCACTGTTAGTTATTAGCCATGACCGCTATTTTCTTGAT
GAAATAGTAGATAAAATATGGGAACTGAAAGATGGCAAAATCACTGAGTATTGGGGAAACTATTCTGATTATCTTCGTCA
GAAAGAGGAAGAACGTAAGAGCCAAGCTGCAGAATACGAACAATTTATTGCGGAACGTGCCCGATTGGAAAGGGCTGCGG
AGGAAAAGCGAAAACAGGCTCGTAAAATAGAACAGAAGGCAAAAGGTTCTTCAAAGAAAAAAAGTACTGAAGACGGAGGG
CGTTTAGCTCATCAAAAATCAATAGGAAGTAAGGAAAAAAAGATGTATAATGCTGCTAAAACCCTAGAGCACAGGATTGC
GGCCTTAGGAAAAGTAGAAGCTCCGGAAGGCATTCGCAGAATTCGTTTCAGGCAAAGTAAAGCATTGGAGCTCCATAATC
CATACCCTATAGTCGGTGCAGAAATTAATAAAGTATTTGGGGATAAGGCTCTGTTTGAAAATGCATCTTTTCAAATTCCG
TTAGGAGCAAAAGTGGCGTTAACTGGTGGTAATGGAATCGGAAAAACAACTTTAATCCAAATGATCTTAAACCATGAAGA
AGGAATTTCTATTTCGCCTAAGGCAAAAATAGGTTACTTTGCACAGAATGGTTACAAGTACAACAGTAATCAGAATGTTA
TGGAGTTTATGCAGAAGGATTGTGACTACAATATATCAGAAATTCGTTCAGTGCTAGCATCTATGGGGTTCAAACAGAAC
GATATTGGAAAAAGTTTATCTGTTTTAAGCGGTGGAGAAATTATAAAATTGTTGCTTGCTAAAATGCTCATGGGTAGATA
TAACATCCTAATAATGGATGAACCCAGTAACTTCCTTGACATACCAAGTTTAGAGGCTTTGGAAATACTAATGAAGGAGT
ACACCGGAACTATCGTGTTTATCACCCACGATAAACGATTACTCGAAAATGTAGCAGATGTAGTTTATGAAATTAGAGAT
AAGAAAATAAATCTGAAACATTAA

Upstream 100 bases:

>100_bases
TATGTATCTTATTTTCATGTAACTCTTCCTGCTAAAATCGCAGGGTTTTCCCTGCATACAAGCAAATGAAAGCATGCGAT
TATAGACAGGAGGAAATGTT

Downstream 100 bases:

>100_bases
ATTTAAGGTAGTCGCTGGTCAGTATAGTCTGTTCTGGTTGGCGACTCCATTGTTAAAGAGTATAAAGACTTTAGATTTTA
TGAATATTAAAAATAGGAAC

Product: Mel protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MELILKAKDIRVEFKGRDVLDINELEVYDYDRIGLVGANGAGKSTLLRVLLGELTPPGCKMNRLGELAYIPQLDEVTLQE
EKDFALVGKLGVEQLNIQTMSGGEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKSQAAEYEQFIAERARLERAAEEKRKQARKIEQKAKGSSKKKSTEDGG
RLAHQKSIGSKEKKMYNAAKTLEHRIAALGKVEAPEGIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIP
LGAKVALTGGNGIGKTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVLASMGFKQN
DIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEILMKEYTGTIVFITHDKRLLENVADVVYEIRD
KKINLKH

Sequences:

>Translated_487_residues
MELILKAKDIRVEFKGRDVLDINELEVYDYDRIGLVGANGAGKSTLLRVLLGELTPPGCKMNRLGELAYIPQLDEVTLQE
EKDFALVGKLGVEQLNIQTMSGGEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKSQAAEYEQFIAERARLERAAEEKRKQARKIEQKAKGSSKKKSTEDGG
RLAHQKSIGSKEKKMYNAAKTLEHRIAALGKVEAPEGIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIP
LGAKVALTGGNGIGKTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVLASMGFKQN
DIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEILMKEYTGTIVFITHDKRLLENVADVVYEIRD
KKINLKH
>Mature_487_residues
MELILKAKDIRVEFKGRDVLDINELEVYDYDRIGLVGANGAGKSTLLRVLLGELTPPGCKMNRLGELAYIPQLDEVTLQE
EKDFALVGKLGVEQLNIQTMSGGEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKSQAAEYEQFIAERARLERAAEEKRKQARKIEQKAKGSSKKKSTEDGG
RLAHQKSIGSKEKKMYNAAKTLEHRIAALGKVEAPEGIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIP
LGAKVALTGGNGIGKTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVLASMGFKQN
DIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEILMKEYTGTIVFITHDKRLLENVADVVYEIRD
KKINLKH

Specific function: Confers resistance to 14-membered ring macrolides (like erythromycin) and to B streptogramins, by acting as an ATP- dependent efflux pump [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI10947137, Length=544, Percent_Identity=24.4485294117647, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI27881506, Length=544, Percent_Identity=24.4485294117647, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI10947135, Length=408, Percent_Identity=24.2647058823529, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI69354671, Length=408, Percent_Identity=24.2647058823529, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148612853, Length=388, Percent_Identity=27.0618556701031, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1789751, Length=532, Percent_Identity=27.8195488721804, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI2367384, Length=540, Percent_Identity=30.5555555555556, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1787041, Length=405, Percent_Identity=30.3703703703704, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1787182, Length=429, Percent_Identity=30.5361305361305, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788165, Length=179, Percent_Identity=28.4916201117318, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=385, Percent_Identity=28.051948051948, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17555318, Length=540, Percent_Identity=23.5185185185185, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17553372, Length=396, Percent_Identity=25.7575757575758, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320874, Length=549, Percent_Identity=24.9544626593807, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6321121, Length=399, Percent_Identity=27.3182957393484, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325030, Length=192, Percent_Identity=26.5625, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323278, Length=180, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324314, Length=180, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641342, Length=541, Percent_Identity=27.1719038817006, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24666836, Length=399, Percent_Identity=28.0701754385965, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24642252, Length=534, Percent_Identity=25.0936329588015, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18859989, Length=534, Percent_Identity=25.0936329588015, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 54875; Mature: 54875

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELILKAKDIRVEFKGRDVLDINELEVYDYDRIGLVGANGAGKSTLLRVLLGELTPPGCK
CCEEEEEEEEEEEECCCCEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCC
MNRLGELAYIPQLDEVTLQEEKDFALVGKLGVEQLNIQTMSGGEETRLKIAQALSAQVHG
HHHCCCEEECCCCCCCHHCCCCCEEEEECCCHHHEEEEEECCCHHHHHHHHHHHHHHHCE
ILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLDEIVDKIWELKDGKITEYWGN
EECCCCHHHHCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHCCCCCCEEHHCCC
YSDYLRQKEEERKSQAAEYEQFIAERARLERAAEEKRKQARKIEQKAKGSSKKKSTEDGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
RLAHQKSIGSKEKKMYNAAKTLEHRIAALGKVEAPEGIRRIRFRQSKALELHNPYPIVGA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEECCCCCCEECC
EINKVFGDKALFENASFQIPLGAKVALTGGNGIGKTTLIQMILNHEEGISISPKAKIGYF
HHHHHHCCHHHHCCCCEEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEE
AQNGYKYNSNQNVMEFMQKDCDYNISEIRSVLASMGFKQNDIGKSLSVLSGGEIIKLLLA
ECCCEEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHH
KMLMGRYNILIMDEPSNFLDIPSLEALEILMKEYTGTIVFITHDKRLLENVADVVYEIRD
HHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHC
KKINLKH
CCCCCCC
>Mature Secondary Structure
MELILKAKDIRVEFKGRDVLDINELEVYDYDRIGLVGANGAGKSTLLRVLLGELTPPGCK
CCEEEEEEEEEEEECCCCEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCC
MNRLGELAYIPQLDEVTLQEEKDFALVGKLGVEQLNIQTMSGGEETRLKIAQALSAQVHG
HHHCCCEEECCCCCCCHHCCCCCEEEEECCCHHHEEEEEECCCHHHHHHHHHHHHHHHCE
ILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLDEIVDKIWELKDGKITEYWGN
EECCCCHHHHCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHCCCCCCEEHHCCC
YSDYLRQKEEERKSQAAEYEQFIAERARLERAAEEKRKQARKIEQKAKGSSKKKSTEDGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
RLAHQKSIGSKEKKMYNAAKTLEHRIAALGKVEAPEGIRRIRFRQSKALELHNPYPIVGA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEECCCCCCEECC
EINKVFGDKALFENASFQIPLGAKVALTGGNGIGKTTLIQMILNHEEGISISPKAKIGYF
HHHHHHCCHHHHCCCCEEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEE
AQNGYKYNSNQNVMEFMQKDCDYNISEIRSVLASMGFKQNDIGKSLSVLSGGEIIKLLLA
ECCCEEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHH
KMLMGRYNILIMDEPSNFLDIPSLEALEILMKEYTGTIVFITHDKRLLENVADVVYEIRD
HHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHC
KKINLKH
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2233255 [H]