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The map label for this gene is aqpZ [H]

Identifier: 225861581

GI number: 225861581

Start: 1618971

End: 1619639

Strand: Reverse

Name: aqpZ [H]

Synonym: SPT_1699

Alternate gene names: 225861581

Gene position: 1619639-1618971 (Counterclockwise)

Preceding gene: 225861582

Following gene: 225861574

Centisome position: 76.68

GC content: 45.29

Gene sequence:

>669_bases
ATGAAAAAATTTGTTGCTGAGTTAATCGGTACGTTCATGCTTGTGTTCGTCGGGACAGGAGCTGTTGTTTTTGGAAATGG
TCTTGATGGCCTTGGTTACCTTGGAATCGCCTTTGCCTTTGGTTTGGCAATCGTGGTGGCAGCCTACTCAATCGGAACTG
TTTCAGGTGCTCACTTGAACCCGGCTGTTTCGATTGCTATGTTTGTAAACAAACGTTTGTCATCTTCAGAACTTGTAAAC
TACATCCTTGGTCAGGTTGTTGGAGCTTTCATCGCTTCTGGCGCTGTCTTCTTCCTCTTGGCTAACTCAGGTATGTCAAC
TGCTAGTCTTGGTGAAAATGCCTTGGCAAACGGTGTCACTGTCTTTGGTGGTTTCTTGTTTGAAGTCATCGCAACTTTCT
TGTTTGTATTGGTTATCATGACTGTGACTTCAGAAAGCAAGGGCAATGGCGCGATTGCTGGTTTGGTAATCGGTTTGTCA
TTGATGGCGATGATTCTTGTCGGATTGAAGATTACTGGACTTTCAGTAAACCCAGCTCGTAGCTTGGCACCAGCTGTCTT
GGTAGGCGGCGCAGCCCTTCAACAAGTTTGGATTTTCATCCTTGCACCAATCGCTGGTGGAGTTCTTGCAGCCCTTGTTG
CAAAAAATTTCCTTGGAACAGAAGAATAA

Upstream 100 bases:

>100_bases
ATAGTTCTATGATTTTCAAAAAATTTCCAATCAATTTTCTTGAAACCCTTTCCTACTTTTGATAGACTAGTATCTAGTTT
TTGAAAAAAGGAGAAAGAAA

Downstream 100 bases:

>100_bases
TTGAAACTCAAAAAGCCTTGCTCCTCATCTTGAGGAACAGGGCTTTTTCGTATGATACTCTTCGAAAATCTCTTCAAACC
ACGTCAGCTTCACCTTGTCG

Product: aquaporin Z - water channel protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGYLGIAFAFGLAIVVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVN
YILGQVVGAFIASGAVFFLLANSGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEE

Sequences:

>Translated_222_residues
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGYLGIAFAFGLAIVVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVN
YILGQVVGAFIASGAVFFLLANSGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEE
>Mature_222_residues
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGYLGIAFAFGLAIVVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVN
YILGQVVGAFIASGAVFFLLANSGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=219, Percent_Identity=34.703196347032, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI4502179, Length=210, Percent_Identity=36.1904761904762, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI4755125, Length=214, Percent_Identity=32.7102803738318, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4502181, Length=214, Percent_Identity=32.7102803738318, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI6912506, Length=215, Percent_Identity=34.8837209302326, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI4502183, Length=218, Percent_Identity=35.3211009174312, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI86792455, Length=218, Percent_Identity=33.0275229357798, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI4502187, Length=247, Percent_Identity=28.3400809716599, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI157266307, Length=241, Percent_Identity=30.7053941908714, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI22538420, Length=232, Percent_Identity=30.6034482758621, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI4826645, Length=249, Percent_Identity=28.5140562248996, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI45446752, Length=215, Percent_Identity=28.8372093023256, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310133356, Length=173, Percent_Identity=28.3236994219653, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI310114181, Length=173, Percent_Identity=28.3236994219653, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=38.4615384615385, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790362, Length=253, Percent_Identity=28.4584980237154, Blast_Score=78, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71993722, Length=233, Percent_Identity=31.3304721030043, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17558372, Length=234, Percent_Identity=31.6239316239316, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71992966, Length=241, Percent_Identity=26.1410788381743, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71994009, Length=246, Percent_Identity=28.8617886178862, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71992961, Length=240, Percent_Identity=25.4166666666667, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17544068, Length=246, Percent_Identity=26.4227642276423, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=203, Percent_Identity=29.5566502463054, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652747, Length=215, Percent_Identity=33.4883720930233, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45551084, Length=215, Percent_Identity=33.4883720930233, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24762344, Length=215, Percent_Identity=33.0232558139535, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550503, Length=229, Percent_Identity=30.1310043668122, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24762346, Length=215, Percent_Identity=33.0232558139535, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24762348, Length=215, Percent_Identity=33.0232558139535, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20130305, Length=215, Percent_Identity=33.0232558139535, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24762342, Length=235, Percent_Identity=31.9148936170213, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922038, Length=219, Percent_Identity=31.9634703196347, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652751, Length=218, Percent_Identity=32.1100917431193, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136672, Length=217, Percent_Identity=29.0322580645161, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 22479; Mature: 22479

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGYLGIAFAFGLAIVVAAYSIGTVSGAHLN
CHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLANSGMSTASLGENALANGVT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHCCCHHHHCCHH
VFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLSLMAMILVGLKITGLSVNPAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGYLGIAFAFGLAIVVAAYSIGTVSGAHLN
CHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLANSGMSTASLGENALANGVT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHCCCHHHHCCHH
VFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLSLMAMILVGLKITGLSVNPAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]