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The map label for this gene is patB [H]

Identifier: 225861357

GI number: 225861357

Start: 1389766

End: 1390932

Strand: Reverse

Name: patB [H]

Synonym: SPT_1462

Alternate gene names: 225861357

Gene position: 1390932-1389766 (Counterclockwise)

Preceding gene: 225861358

Following gene: 225861356

Centisome position: 65.85

GC content: 41.82

Gene sequence:

>1167_bases
ATGGGAAAATATGATTTTACAAGCCTGCCCAACCGTTTAGGGCACCATACCTATAAATGGAAAGAAACAGAAACGGATAG
TGAAGTTCTACCAGCTTGGATAGCGGATATGGACTTTGTGGTCTTGCCTGAAATCCGCCAAGCCGTGCAAACTTACGCAG
ACCAACTGGTTTATGGTTATACCTATGCCAGTGAAGACTTAATTAAGGAAGTTCAAAAGTGGGAAGCTACACAATACGGT
TACAACTTTGACAAAGAGGCTCTTGTCTTTATCGAGGGTGTGGTACCAGCCATCTCAACAGCTATTCAAACCTTTACAAA
AGAAGGCGAGGCGGTTTTAATTAACACGCCTGTCTACCCACCCTTTGCTCGCAGTGTCAAGTTGAATAATCGTAGATTGA
TTACTAATTCCTTAGTGGAAAAGGATAGTCTGTTTGAGATTGACTTTGACCAACTTGAAAAGGATTTGGTGGAAGAGGAG
GTTAAACTCTATGTTCTTTGCAACCCTCACAATCCTGGTGGACGTGTTTGGGAAAAAGAAGTGTTGGAGAAGATTGGCCA
ACTCTGCCAAAAACACGGTGTTTTGTTAGTTTCGGATGAGATTCACCAAGATTTGACCCTCTTTGGTCACAAACACCAGT
CTTTCAATACCATCAATCCTGCCTTCAAAAATTTTGCTATCGTCTTGAGCAGTGCCACTAAAACATTTAATATTGCTGGA
ACAAAAAATTCCTATGCAGTCATTGAAAATCCTAAGTTGAGACTGGCTTTCCAGAAACGCCTGTTGGCCAATAATCAGCA
TGAAATTTCAGGCTTGGGTTATTTGGCGACAGAAGCTGCCTATCGATACGGTAAAGATTGGCTAGAGGAACTCAAGCAAG
TCTTTGAAGACCACATCAATTATGTGATGGATCTATTTGGAAAAGAGACTAAAATCAAGGTCATGAAACCGCAAGGTACC
TACTTGATTTGGCTTGACTTTTCAGCTTATGACCTGACTGATGAAACATTGCAAGAGTTGTTGAGAAATGAAGCCAAGGT
TATCCTCAACCGTGGTTTGGATTTTGGAGAGGAAGGAAGTCTCCATGCCCGCATCAATATAGCTATGCCCAAATCTCTGT
TGCAAGAAGTCTGTCAGCGGATTGTGGCTACTTTTGCCAAACGTTAA

Upstream 100 bases:

>100_bases
TATGGTTTGACAGATGACCTCTTGCGTTTGTCTATTGGGATTGAGGATGCTAGAGATTTGATTGCAGATTTGCGCCAAGC
CTTAGAAGGATAAGACAAAG

Downstream 100 bases:

>100_bases
AAATCCAGCCTTCTAGGAGAAAAGTCTTCCTAGAAGGCTATTTTCATAGGCGAAAATATGGTATAATAAAAAGATAAGGT
AAAGGTGAAAATATGGCTAA

Product: putative aminotransferase B

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPEIRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYG
YNFDKEALVFIEGVVPAISTAIQTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEE
VKLYVLCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTINPAFKNFAIVLSSATKTFNIAG
TKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLATEAAYRYGKDWLEELKQVFEDHINYVMDLFGKETKIKVMKPQGT
YLIWLDFSAYDLTDETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR

Sequences:

>Translated_388_residues
MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPEIRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYG
YNFDKEALVFIEGVVPAISTAIQTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEE
VKLYVLCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTINPAFKNFAIVLSSATKTFNIAG
TKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLATEAAYRYGKDWLEELKQVFEDHINYVMDLFGKETKIKVMKPQGT
YLIWLDFSAYDLTDETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR
>Mature_387_residues
GKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPEIRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYGY
NFDKEALVFIEGVVPAISTAIQTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEEV
KLYVLCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTINPAFKNFAIVLSSATKTFNIAGT
KNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLATEAAYRYGKDWLEELKQVFEDHINYVMDLFGKETKIKVMKPQGTY
LIWLDFSAYDLTDETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=321, Percent_Identity=24.2990654205607, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI169881279, Length=321, Percent_Identity=24.2990654205607, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI56713256, Length=175, Percent_Identity=29.7142857142857, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI56713254, Length=175, Percent_Identity=29.7142857142857, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787909, Length=379, Percent_Identity=31.1345646437995, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1786816, Length=276, Percent_Identity=23.9130434782609, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788627, Length=296, Percent_Identity=24.6621621621622, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788722, Length=361, Percent_Identity=22.1606648199446, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=309, Percent_Identity=22.6537216828479, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=244, Percent_Identity=27.8688524590164, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=244, Percent_Identity=27.8688524590164, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17567369, Length=236, Percent_Identity=25, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=321, Percent_Identity=22.4299065420561, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18859735, Length=350, Percent_Identity=23.4285714285714, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573069, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646114, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573067, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573065, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44512; Mature: 44381

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPEIRQAVQTYADQLVYGY
CCCCCCCCCCHHHCCCCEECCCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHEE
TYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAIQTFTKEGEAVLINTPVYP
EECCHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCC
PFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEEVKLYVLCNPHNPGGRVWEKE
CCCCCEECCCCEEHHHHHHCCCCEEECCHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHH
VLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTINPAFKNFAIVLSSATKTFNIAG
HHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHEEEEECCCCEEEEEC
TKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLATEAAYRYGKDWLEELKQVFEDHIN
CCCCEEEEECCCCHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVMDLFGKETKIKVMKPQGTYLIWLDFSAYDLTDETLQELLRNEAKVILNRGLDFGEEGS
HHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
LHARINIAMPKSLLQEVCQRIVATFAKR
EEEEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPEIRQAVQTYADQLVYGY
CCCCCCCCCHHHCCCCEECCCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHEE
TYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAIQTFTKEGEAVLINTPVYP
EECCHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCC
PFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEEVKLYVLCNPHNPGGRVWEKE
CCCCCEECCCCEEHHHHHHCCCCEEECCHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHH
VLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTINPAFKNFAIVLSSATKTFNIAG
HHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHEEEEECCCCEEEEEC
TKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLATEAAYRYGKDWLEELKQVFEDHIN
CCCCEEEEECCCCHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVMDLFGKETKIKVMKPQGTYLIWLDFSAYDLTDETLQELLRNEAKVILNRGLDFGEEGS
HHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
LHARINIAMPKSLLQEVCQRIVATFAKR
EEEEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]