Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 225861173

GI number: 225861173

Start: 1202773

End: 1203570

Strand: Reverse

Name: proC [H]

Synonym: SPT_1266

Alternate gene names: 225861173

Gene position: 1203570-1202773 (Counterclockwise)

Preceding gene: 225861174

Following gene: 225861172

Centisome position: 56.98

GC content: 44.74

Gene sequence:

>798_bases
ATGAAGATTGGATTTATCGGTTTGGGGAATATGGGTGCTAGCTTGGCAAAATCTGTCTTGCAGACTAGGACGTCAGATGA
GATTCTCCTTGCCAATCGTAGTCAAGCTAAGGTAGATGCTTTCATTGCAGACTTTGGTGGTCAGGCTTCCAGCAATGAAG
AAATGTTTGCAGAAGCAGATGTGATTTTTCTAGGAGTTAAGCCTGCTCAGTTTTCTGAACTGCTTTCTCAATACCAGACC
ATCCTTGAAAAAAGAGAAAGTCTTCTTTTGATTTCGATGGCAGCTGGATTGACCTTAGAAAAACTAGCAAGTCTTATCCC
AAGTCAACACCGAATTATTCGTATGATGCCTAATACCCCTGCTTCTATCGGGCAAGGAGTGATTAGTTATGCCTTGTCTC
CTAATTGCAGGGCTGAGGACAGTGAGCTCTTTTGTCAGCTTTTATCCAAGGCTGGTCTCTTGGTTGAATTAGGAGAAAGC
TTAATCAATGCAGCGACAGGTCTTGCAGGCTGTGGACCAGCCTTTGTCTATCTCTTTATTGAAGCCTTGGCAGATGCAGG
TGTTCAGACGGGATTATCACGAGAAACAGCCTTGAAAATGGCAGCCCAAACTGTGGTAGGAGCTGGGCAATTGGTCCTAG
AAAGCCAGCAACATCCTGGAGTTTTGAAAGATCAAGTTTGTAGTCCAGGCGGTTCGACTATTGCTGGCGTAGCAAGCCTA
GAAGCGCATGCTTTTCGAGGCACAGTCATGGAGGCAGTTCATCAAGCCTATAAACGAACACAAGAACTAGGTAAATAA

Upstream 100 bases:

>100_bases
TTCTACTCAGAAATTGCACGCGCGTGGTCCAATGGGCTTGAAAGAGTTGACCAGCTACAAGTATGTGGTTGCTGGTGATG
GGCAGATAAGGGAGTAAGAG

Downstream 100 bases:

>100_bases
GAGGTAGCTTTATCTGCCTCTTTTATGGTGGTTGATACTCTTCGAAAATCAAATTCAAACTGCGTCAGCTTCACCTTGCC
GTACTCAAGTACAGCCTGCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLSRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGTVMEAVHQAYKRTQELGK

Sequences:

>Translated_265_residues
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLSRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGTVMEAVHQAYKRTQELGK
>Mature_265_residues
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLSRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGTVMEAVHQAYKRTQELGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=38.1818181818182, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=38.1818181818182, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=37.4545454545455, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=31.203007518797, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=39.7769516728625, Blast_Score=181, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=39.5522388059701, Blast_Score=198, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=33.2142857142857, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320861, Length=214, Percent_Identity=35.5140186915888, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=38.3512544802867, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21358587, Length=274, Percent_Identity=35.7664233576642, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=41.0714285714286, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27929; Mature: 27929

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEAD
CEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHCCC
VIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTP
EEEEECCHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCHHHHHHHCCCCCCEEEECCCCC
ASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGESLINAATGLAGCGPAFVYLFI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EALADAGVQTGLSRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHCCCCCCHHHHHHHH
EAHAFRGTVMEAVHQAYKRTQELGK
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEAD
CEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHCCC
VIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTP
EEEEECCHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCHHHHHHHCCCCCCEEEECCCCC
ASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGESLINAATGLAGCGPAFVYLFI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EALADAGVQTGLSRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHCCCCCCHHHHHHHH
EAHAFRGTVMEAVHQAYKRTQELGK
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]