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The map label for this gene is pyrH [H]

Identifier: 225861167

GI number: 225861167

Start: 1197448

End: 1198185

Strand: Reverse

Name: pyrH [H]

Synonym: SPT_1260

Alternate gene names: 225861167

Gene position: 1198185-1197448 (Counterclockwise)

Preceding gene: 225861168

Following gene: 225861166

Centisome position: 56.73

GC content: 44.72

Gene sequence:

>738_bases
ATGGCGAATCCCAAGTATAAACGTATTTTAATCAAGTTATCAGGTGAAGCCCTTGCCGGTGAACGTGGCGTAGGGATTGA
TATCCAAACAGTTCAAACAATCGCAAAAGAGATTCAAGAAGTTCATAGCTTAGGTATCGAAATTGCCCTTGTTATTGGTG
GAGGAAATCTCTGGCGTGGAGAACCTGCAGCAGAAGCAGGTATGGACCGTGTTCAGGCAGATTACACTGGAATGCTTGGG
ACTGTTATGAATGCTCTTGTGATGGCAGATTCATTGCAACAAGTTGGGGTTGATACGCGTGTACAAACAGCTATTGCCAT
GCAACAAGTGGCAGAGCCTTATGTCCGTGGACGTGCCCTTCGTCACCTTGAAAAAGGCCGTATCGTTATCTTTGGTGCTG
GAATTGGTTCACCATACTTCTCGACAGATACAACAGCGGCCCTTCGTGCAGCTGAAATCGAAGCAGATGCCATCCTCATG
GCTAAAAATGGCGTCGATGGTGTGTACAATGCCGATCCTAAGAAGGACAAGACAGCCGTTAAGTTTGAAGAATTGACCCA
CCGTGATGTTATCAACAAAGGTCTTCGTATCATGGACTCAACAGCCTCAACCCTCTCAATGGACAACGACATTGACTTGG
TTGTCTTCAACATGAACCAATCAGGCAACATCAAACGTGTCGTATTTGGTGAAAATATCGGAACAACAGTTTCAAATAAT
ATCGAAGAAAAGGAATAA

Upstream 100 bases:

>100_bases
AATTTTTGACTGTCTAATTTTTTTGAAAGAATTGCTCATGATACTATAAAAATCTTAGAAATTGTGATAAAATAGGTAGG
ATGAAAGAAGGAGAGTGAAA

Downstream 100 bases:

>100_bases
GAAAGAATATGGCTAACGTAATTATTGAAAAAGCTAAAGAGAGAATGACCCAGTCTCACCAATCACTTGCTCGTGAATTT
GGTGGTATCCGTGCTGGTCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLG
TVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILM
AKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNIKRVVFGENIGTTVSNN
IEEKE

Sequences:

>Translated_245_residues
MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLG
TVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILM
AKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNIKRVVFGENIGTTVSNN
IEEKE
>Mature_244_residues
ANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGT
VMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILMA
KNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNIKRVVFGENIGTTVSNNI
EEKE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=237, Percent_Identity=49.3670886075949, Blast_Score=234, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26434; Mature: 26302

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRG
CCCCCEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCC
EPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILMAKNGVDGVYNADPKKDKTAV
HHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHH
KFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNIKRVVFGENIGTTVSNN
HHHHHHHHHHHHHCCEEECCCHHHEECCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCC
IEEKE
CCCCC
>Mature Secondary Structure 
ANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRG
CCCCEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCC
EPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILMAKNGVDGVYNADPKKDKTAV
HHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHH
KFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNIKRVVFGENIGTTVSNN
HHHHHHHHHHHHHCCEEECCCHHHEECCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCC
IEEKE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]