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The map label for this gene is ung [H]

Identifier: 225861108

GI number: 225861108

Start: 1141655

End: 1142308

Strand: Reverse

Name: ung [H]

Synonym: SPT_1194

Alternate gene names: 225861108

Gene position: 1142308-1141655 (Counterclockwise)

Preceding gene: 225861109

Following gene: 225861107

Centisome position: 54.08

GC content: 44.19

Gene sequence:

>654_bases
ATGGAACACTCGTCTTGGCATGCTTTGATTAAGGCGCAATTACCTGAGGGTTATTTCGGGAAAATCAATCAGTTTATGGA
GCAGGTCTATTCTCAGGGGATTATTTATCCACCCAAGGAAAAGGTTTTTCAGGCTCTCTTGACAACACTGCTTGAAGAAG
TTAAGGTGGTAATTCTAGGGCAAGACCCCTATCACGGACCAGGTCAAGCGCAGGGCTTGAGTTTTTCTGTACCTGACTCT
ATCCCAGCTCCACCATCCTTGCAAAATATCTTGAAAGAATTGTCAGATGATATCGGAGTTAAGAAATCTCATGATTTGAC
AGCTTGGGCTGAGCAAGGAGTCTTGCTTCTTAATGCTTGTTTGACTGTTCCTGCTGGACAGGCCAATGGTCATGCTGGTC
AAATCTGGGAGCCTTTTACTGATGCTGTGATTCAGGTGGTCAATCATCTAGATAGACCAGTCGTTTTTGTACTCTGGGGA
GCTTATGCACGTAAGAAGAAGGCCTTAGTTACCAATCCTCATCACTTGATTATCGAATCAGCCCATCCAAGTCCTTTGTC
GGTTTATAGAGGATTTTGGGGTTCCAAGCCCTTTTCCAAGGCCAATGCATTCTTAAAAGAGACAGGACAAGAGCCAATCG
ATTGGCTTAGATAA

Upstream 100 bases:

>100_bases
GTATATAGTCGATTTATTAAATCTTTAGATAAATTGTAAAAAGTGGTTTCCATAGCCACTTTTTGCTATAATAGAGGCAG
TAAAAATGAAGGAGTCAGCT

Downstream 100 bases:

>100_bases
GGAGAAAATATGCCTCAGTTAGCGACGATTTGCTACATTGATAATGGGAAAGAACTGCTCATGCTCCATCGTAATAAGAA
ACCCAATGATGTCCATGAAG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDS
IPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR

Sequences:

>Translated_217_residues
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDS
IPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR
>Mature_217_residues
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDS
IPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=214, Percent_Identity=50.4672897196262, Blast_Score=211, Evalue=3e-55,
Organism=Homo sapiens, GI6224979, Length=214, Percent_Identity=50.4672897196262, Blast_Score=211, Evalue=3e-55,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=48.6111111111111, Blast_Score=199, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=44.9074074074074, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323620, Length=230, Percent_Identity=41.304347826087, Blast_Score=158, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24050; Mature: 24050

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILG
CCCCHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEC
QDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNAC
CCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHH
LTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWGAYARKKKALVTNPHHLIIES
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCEECCCCEEEEEC
AHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQALLTTLLEEVKVVILG
CCCCHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEC
QDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKKSHDLTAWAEQGVLLLNAC
CCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHH
LTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWGAYARKKKALVTNPHHLIIES
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCEECCCCEEEEEC
AHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA