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The map label for this gene is pyrC [H]

Identifier: 225861106

GI number: 225861106

Start: 1139900

End: 1141168

Strand: Reverse

Name: pyrC [H]

Synonym: SPT_1192

Alternate gene names: 225861106

Gene position: 1141168-1139900 (Counterclockwise)

Preceding gene: 225861107

Following gene: 225861105

Centisome position: 54.03

GC content: 43.66

Gene sequence:

>1269_bases
ATGCTACTAATCAAAAATGGTCATGTAATGGATCCCAAGTCTGGTTTGGATCAAGTTTGTGATGTCTTAGTTCAAGATGG
GAAAATTATCAAAATTGCGCCTGAGATCACGGAAGAAGGAGCAGAAACGATTGATGCTACTGGTCTTGTGGTTGCTCCTG
GTTTGGTCGATATTCATGTGCATTTCCGTGAACCTGGTCAAACACATAAAGAAGACATTCATACTGGTGCCCTAGCAGCC
GCTGCAGGTGGTTTTACTACTGTCGTCATGATGGCTAATACCAGTCCAACCATTTCAGACGTGGAGACTTTGCAAGCAGT
TCTCCAGTCAGCTGCCAAAGAGAAGATTAATGTCAAGACAGTTGCGACCATTACTAAAAACTTTAATGGTAAAAACTTGA
CTGACTTTAAGGCGCTCTTAGAAGCTGGTGCGGTTGGTTTCTCTGATGACGGTATTCCGCTTGAGAGCAGTAAGATTGTC
AAGGAAGCCATGGAGGAAGCCAAAAAACTCAATACCTTTATCAGCCTTCATGAGGAAGATCCAGGTTTGAACGGTGTTCT
TGGCTTTAATGAAAATATTGCTAGAGAACATTTCCATATCTGCGGTGCTACTGGGGTGGCTGAGTACGCTATGATGGCGC
GTGATGTCATGATTGCCTATGCAACTAAAGCCCATGTTCACATCCAGCATTTGTCTAAGGAAGAAAGTGTTAAAGTAGTG
GAGTTTGCTCAGGGGTTAGGTGCAGAAGTCACAGCAGAAGTAGCGCCACAGCATTTCTCTAAGACAGAAGCACTTCTTTT
AACACAAGGTAGCAATGCTAAGATGAATCCACCGCTTCGTTTGGAATCAGACCGTCGTGCCGTTATCGAAGGTCTCAAAT
CAGGTGTCATCACAGTTATTGCGACTGACCACGCGCCTCATCATGTAGATGAAAAAAATGTTGAGGATATTACCAAAGCG
CCATCTGGTATGACTGGCTTAGAAACATCTCTGTCTCTCGGCTTGACCTATTTAGTAGAAGCTGGTGAGTTGAGCTTGAT
GGAATTACTTGAAAAAATGACATACAACCCAGCCAAGCTTTACAACTTTGAAGCAGGTTACTTGGCTGAGAATGGTCCAG
CAGATATCACTATTTTTGATGCCAAGGCTGACCGCCTTGTGGACTCCCATTTTGCTTCCAAAGCAGCTAATTCACCATTC
ATCGGTGAAACCTTAAAAGGGCAGGTTAAATATACCATCTGTAAGGGACAAATCGTCTATCAAGCTTGA

Upstream 100 bases:

>100_bases
GCTTTTAGAGGATAAACCCTTCTTTTCAGCCAAGTTTGTTTATGATGGGGATAAATTGTTGGATACCCAAGTTGATTTCT
ATGAATAAAGGAGAAAGCAG

Downstream 100 bases:

>100_bases
TAGGAGTTAGAATATGAATTATTTTCGAAAACGTAGGGAGAGACAAGCGAAATCTAATAGTGGAATTTACTGTCCCGCAG
CTAATCGTTCCAAAATTCAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLLIKNGHVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKA
PSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKLYNFEAGYLAENGPADITIFDAKADRLVDSHFASKAANSPF
IGETLKGQVKYTICKGQIVYQA

Sequences:

>Translated_422_residues
MLLIKNGHVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKA
PSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKLYNFEAGYLAENGPADITIFDAKADRLVDSHFASKAANSPF
IGETLKGQVKYTICKGQIVYQA
>Mature_422_residues
MLLIKNGHVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKA
PSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKLYNFEAGYLAENGPADITIFDAKADRLVDSHFASKAANSPF
IGETLKGQVKYTICKGQIVYQA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=383, Percent_Identity=32.1148825065274, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4503375, Length=455, Percent_Identity=25.4945054945055, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4503051, Length=462, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI62422571, Length=464, Percent_Identity=24.1379310344828, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786722, Length=438, Percent_Identity=28.5388127853881, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87082175, Length=455, Percent_Identity=26.1538461538462, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=382, Percent_Identity=28.5340314136126, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=25.4504504504505, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17539558, Length=464, Percent_Identity=26.9396551724138, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=428, Percent_Identity=29.2056074766355, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24642586, Length=388, Percent_Identity=29.1237113402062, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI17137462, Length=441, Percent_Identity=24.7165532879819, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI18859883, Length=418, Percent_Identity=27.0334928229665, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI221377917, Length=456, Percent_Identity=25, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45282; Mature: 45282

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIKNGHVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHV
CEEECCCCEECCCCCHHHHHHHHHCCCCEEEECCHHHHCCHHHCCCCCEEEECCEEEEEE
HFREPGQTHKEDIHTGALAAAAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKT
EECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
VATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIVKEAMEEAKKLNTFISLHEED
EEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCC
PGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
CCCCEEECCCCCHHHHHHEEECCHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCHHH
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVI
HHHCCCCCCEEHHHCHHHCCCCCEEEEECCCCCCCCCCEEECCCHHHHHHHHCCCEEEEE
ATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKL
EECCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHCEEEEEECCCHHHHHHHHHHCCCCHHE
YNFEAGYLAENGPADITIFDAKADRLVDSHFASKAANSPFIGETLKGQVKYTICKGQIVY
EECCCCEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECEEEE
QA
EC
>Mature Secondary Structure
MLLIKNGHVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHV
CEEECCCCEECCCCCHHHHHHHHHCCCCEEEECCHHHHCCHHHCCCCCEEEECCEEEEEE
HFREPGQTHKEDIHTGALAAAAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKT
EECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
VATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIVKEAMEEAKKLNTFISLHEED
EEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCC
PGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
CCCCEEECCCCCHHHHHHEEECCHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCHHH
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVI
HHHCCCCCCEEHHHCHHHCCCCCEEEEECCCCCCCCCCEEECCCHHHHHHHHCCCEEEEE
ATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKL
EECCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHCEEEEEECCCHHHHHHHHHHCCCCHHE
YNFEAGYLAENGPADITIFDAKADRLVDSHFASKAANSPFIGETLKGQVKYTICKGQIVY
EECCCCEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECEEEE
QA
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]