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The map label for this gene is thrC

Identifier: 225859823

GI number: 225859823

Start: 1973323

End: 1974807

Strand: Reverse

Name: thrC

Synonym: SP70585_2157

Alternate gene names: 225859823

Gene position: 1974807-1973323 (Counterclockwise)

Preceding gene: 225859824

Following gene: 225859822

Centisome position: 90.39

GC content: 40.74

Gene sequence:

>1485_bases
ATGACATTAGTTTATCAATCAACGCGTGATGCCAACAATACAGTAACTGCCAGCCAAGCAATTTTGCAAGGTTTGGCGAC
GGACGGCGGTTTGTTTACACCGGTTACTTATCCAAAGGTAGATTTGAACTTTGACAAATTGAAAGATGCTTCTTACCAGG
AAGTTGCTAAGCTAGTTTTGTCAGCATTTTTAGATGACTTTACAGTTGAGGAGTTGGACTACTGTATCAACAATGCCTAC
GATAGCAAATTTGATACTCCAGCTATTGCACCATTAGTGAAATTAGATGGGCAATACAATTTGGAACTTTTCCATGGTTC
AACGATTGCCTTTAAGGATATGGCCTTGTCTATTTTGCCATACTTTATGACGACTGCTGCTAAGAAACATGGTTTGGAGA
ACAAGATTGTTATCTTGACAGCGACATCTGGTGACACGGGGAAAGCTGCTATGGCGGGGTTTGCGAATGTGCCTGGTACT
GAGATTATCGTCTTTTATCCAAAGGATGGTGTCAGCAAGATTCAAGAGTTACAAATGACCACTCAGACTGGCGACAATAC
TCATGTTATTGCTATTGATGGTAACTTTGACGATGCGCAAACAAATGTGAAGCACATGTTTAACGACGTGGCTCTTCGTG
AAAAATTGACTACCAACAAGTTGCAATTTTCATCAGCTAACTCTATGAACATTGGTCGTCTGGTGCCACAAATTGTTTAT
TATGTTTATGCTTACGCTCAATTGGTTAAGACTGGTGAAATTGTAGCTGGTGAAAAGGTTAACTTCACAGTACCAACAGG
AAACTTTGGAAATATCTTGGCTGCCTTTTATGCCAAACAAATTGGTTTGCCAGTTGGTAAATTAATCTGTGCTTCAAATG
ACAACAATGTTTTGACAGACTTCTTTAAAACACGTGTCTATGACAAAAAACGTGAGTTTAAGGTAACAACCAGCCCATCT
ATGGATATCTTGGTATCTTCAAACTTGGAGCGCTTGATTTTCCATCTTTTGGGAAATAATGCTGAAAAGACAACTGAACT
TATGAATGCCTTGAACACGCAAGGACAATATAAGTTGACAGACTTTGATGCAGAGATTTTGGACCTCTTTGCAGCTGAAT
ATGCGACTGAGGAAGAAACGGCAGCAGAGATCAAGCGTGTTTGTGAGTTAGATTCTTATATCGAGGACCCTCATACAGCT
GTTGCTTCAGCAGTTTATAAAAAATACCAATCGGCCACTGGAGATGTAACTAAGACAGTGATTGCTTCAACAGCTAGTCC
ATACAAGTTCCCAGTAGTTGCAGTAGAAGCTGTAACTGGAAAAGCAGGTTTAACAGACTTTGAAGCCTTGGCTCAATTAC
ATGAAATCTCAGGCGTTGCAGTGCCACCAGCAGTTGATGGGCTTGAAATAGCTCCAATTCGTCACAAGACAACAGTGGCA
GCTGCTGACATGCAAGCAGCGGTTGAGGCTTATTTAGGACTTTAA

Upstream 100 bases:

>100_bases
TTTGAGAGAAGAATTGAGCCTATAATTTCTCTTATAAAGGGAGAATTTTCTGAAAAATCATGATATAATGGACGAGACTA
TAGATAAAGGATAGAGAGTA

Downstream 100 bases:

>100_bases
GACAGAGGGAGCAAACTCGGTTGGGAAACCAACTGAGTTTCTTTTCATCAGGAGGAGAGATTGTTTAAGAAAAATAAAGA
CATTCTTAATATTGCATTGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLNFDKLKDASYQEVAKLVLSAFLDDFTVEELDYCINNAY
DSKFDTPAIAPLVKLDGQYNLELFHGSTIAFKDMALSILPYFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFANVPGT
EIIVFYPKDGVSKIQELQMTTQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTTNKLQFSSANSMNIGRLVPQIVY
YVYAYAQLVKTGEIVAGEKVNFTVPTGNFGNILAAFYAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPS
MDILVSSNLERLIFHLLGNNAEKTTELMNALNTQGQYKLTDFDAEILDLFAAEYATEEETAAEIKRVCELDSYIEDPHTA
VASAVYKKYQSATGDVTKTVIASTASPYKFPVVAVEAVTGKAGLTDFEALAQLHEISGVAVPPAVDGLEIAPIRHKTTVA
AADMQAAVEAYLGL

Sequences:

>Translated_494_residues
MTLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLNFDKLKDASYQEVAKLVLSAFLDDFTVEELDYCINNAY
DSKFDTPAIAPLVKLDGQYNLELFHGSTIAFKDMALSILPYFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFANVPGT
EIIVFYPKDGVSKIQELQMTTQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTTNKLQFSSANSMNIGRLVPQIVY
YVYAYAQLVKTGEIVAGEKVNFTVPTGNFGNILAAFYAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPS
MDILVSSNLERLIFHLLGNNAEKTTELMNALNTQGQYKLTDFDAEILDLFAAEYATEEETAAEIKRVCELDSYIEDPHTA
VASAVYKKYQSATGDVTKTVIASTASPYKFPVVAVEAVTGKAGLTDFEALAQLHEISGVAVPPAVDGLEIAPIRHKTTVA
AADMQAAVEAYLGL
>Mature_493_residues
TLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLNFDKLKDASYQEVAKLVLSAFLDDFTVEELDYCINNAYD
SKFDTPAIAPLVKLDGQYNLELFHGSTIAFKDMALSILPYFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFANVPGTE
IIVFYPKDGVSKIQELQMTTQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTTNKLQFSSANSMNIGRLVPQIVYY
VYAYAQLVKTGEIVAGEKVNFTVPTGNFGNILAAFYAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPSM
DILVSSNLERLIFHLLGNNAEKTTELMNALNTQGQYKLTDFDAEILDLFAAEYATEEETAAEIKRVCELDSYIEDPHTAV
ASAVYKKYQSATGDVTKTVIASTASPYKFPVVAVEAVTGKAGLTDFEALAQLHEISGVAVPPAVDGLEIAPIRHKTTVAA
ADMQAAVEAYLGL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=473, Percent_Identity=39.5348837209302, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI149193323, Length=448, Percent_Identity=31.4732142857143, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI1786185, Length=436, Percent_Identity=31.651376146789, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319901, Length=471, Percent_Identity=36.0934182590234, Blast_Score=259, Evalue=5e-70,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53753; Mature: 53621

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLNFDKLKDASYQEVAKLVL
CEEEEECCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCEECCCHHHHCCCCHHHHHHHHH
SAFLDDFTVEELDYCINNAYDSKFDTPAIAPLVKLDGQYNLELFHGSTIAFKDMALSILP
HHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHEEECCCEEEEEEECCEEEHHHHHHHHHH
YFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFANVPGTEIIVFYPKDGVSKIQELQMT
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHH
TQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTTNKLQFSSANSMNIGRLVPQIVY
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHH
YVYAYAQLVKTGEIVAGEKVNFTVPTGNFGNILAAFYAKQIGLPVGKLICASNDNNVLTD
HHHHHHHHHHCCCEEECCEEEEEECCCCHHHHHHHHHHHHHCCCHHHEEEECCCCCHHHH
FFKTRVYDKKREFKVTTSPSMDILVSSNLERLIFHLLGNNAEKTTELMNALNTQGQYKLT
HHHHHHHCCCCCEEEECCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEE
DFDAEILDLFAAEYATEEETAAEIKRVCELDSYIEDPHTAVASAVYKKYQSATGDVTKTV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHH
IASTASPYKFPVVAVEAVTGKAGLTDFEALAQLHEISGVAVPPAVDGLEIAPIRHKTTVA
HHCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHH
AADMQAAVEAYLGL
HHHHHHHHHHHHCC
>Mature Secondary Structure 
TLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLNFDKLKDASYQEVAKLVL
EEEEECCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCEECCCHHHHCCCCHHHHHHHHH
SAFLDDFTVEELDYCINNAYDSKFDTPAIAPLVKLDGQYNLELFHGSTIAFKDMALSILP
HHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHEEECCCEEEEEEECCEEEHHHHHHHHHH
YFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFANVPGTEIIVFYPKDGVSKIQELQMT
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHH
TQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTTNKLQFSSANSMNIGRLVPQIVY
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHH
YVYAYAQLVKTGEIVAGEKVNFTVPTGNFGNILAAFYAKQIGLPVGKLICASNDNNVLTD
HHHHHHHHHHCCCEEECCEEEEEECCCCHHHHHHHHHHHHHCCCHHHEEEECCCCCHHHH
FFKTRVYDKKREFKVTTSPSMDILVSSNLERLIFHLLGNNAEKTTELMNALNTQGQYKLT
HHHHHHHCCCCCEEEECCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEE
DFDAEILDLFAAEYATEEETAAEIKRVCELDSYIEDPHTAVASAVYKKYQSATGDVTKTV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHH
IASTASPYKFPVVAVEAVTGKAGLTDFEALAQLHEISGVAVPPAVDGLEIAPIRHKTTVA
HHCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHH
AADMQAAVEAYLGL
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]