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The map label for this gene is trpC

Identifier: 225859584

GI number: 225859584

Start: 1741316

End: 1742083

Strand: Reverse

Name: trpC

Synonym: SP70585_1875

Alternate gene names: 225859584

Gene position: 1742083-1741316 (Counterclockwise)

Preceding gene: 225859585

Following gene: 225859583

Centisome position: 79.74

GC content: 46.09

Gene sequence:

>768_bases
ATGAGTCAGGAATTTTTAGCACGAATCTTAGAGCAGAAGGCGCATGAGGTGGAGCAGATGAAGCTGGAGCAAATCCAGCC
TCTGCGCCAGACCTATCGCTTGGCAGAATTTTTGAAGAATCATCAGGACCGCTTGCAGGTAATCGCTGAGGTCAAGAAAG
CTAGCCCTAGTTTGGGAGATATCAATCTCGATGTGGATATTGTGCAACAGGCCCAGACTTATGAAGAAAACGGAACAGTG
ATGATTTCGGTGTTGACAGATGAGGTTTTCTTTAAAGGGCATTTGAATTATCTACGGGAAATTTCCAGTCAGGTAGAGAT
TCCGACGCTCAACAAAGACTTTATCATAGATGAAAAGCAAATCATCCGCGCTCGCAATGCAGGTGCGACAGTTATCTTGC
TTATTGTGGCAGCCTTGTCCGAAGAACGCCTCAAGAAACTGTATGACTACGCGACAGAGCTTGGTCTGGAAGTCTTAGTG
GAGACTCACAATCTAGCTGAACTAGAGGTAGCCCACAGACTTGGTGCTGAGATTATCGGGGTCAACAACCGCAACTTGAC
TACCTTTGAGGTCGACTTGCAGACCAGTGTAGATTTAGCCCCTTACTTTGAGGAAGGTCGCTATTACATTTCTGAATCTG
CTATTTTCACAGGGCAGGATGCGGAACGACTAGCCCCATACTTTAACGGAATTTTGGTAGGGACAGCTCTTATGCAGGCA
GAAAATGTGGCCCAGAGAATCAAGGAGTTGCAGATTGACAAAGGTTAA

Upstream 100 bases:

>100_bases
GTAAGATTGATAGCATCAAGGAAGGGGTTGCCTTGGCCCGTCAAGTGATTGCTAGAGGCAAGGCCCTTGAAAAACTCAGA
CTGTTACAGGAGTACCAAAA

Downstream 100 bases:

>100_bases
AATTTGTGGACTATCGACCAAAGAAGCGGTGGAAACAGCCGTTTCAGCAGGAGCCGACTATATCGGTTTTGTCTTTGCAC
CTAGTAAAAGACAGGTGACT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSQEFLARILEQKAHEVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGTV
MISVLTDEVFFKGHLNYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKKLYDYATELGLEVLV
ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
ENVAQRIKELQIDKG

Sequences:

>Translated_255_residues
MSQEFLARILEQKAHEVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGTV
MISVLTDEVFFKGHLNYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKKLYDYATELGLEVLV
ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
ENVAQRIKELQIDKG
>Mature_254_residues
SQEFLARILEQKAHEVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGTVM
ISVLTDEVFFKGHLNYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKKLYDYATELGLEVLVE
THNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQAE
NVAQRIKELQIDKG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=256, Percent_Identity=36.71875, Blast_Score=134, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=233, Percent_Identity=40.343347639485, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28949; Mature: 28818

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEFLARILEQKAHEVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
INLDVDIVQQAQTYEENGTVMISVLTDEVFFKGHLNYLREISSQVEIPTLNKDFIIDEKQ
CCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHH
IIRARNAGATVILLIVAALSEERLKKLYDYATELGLEVLVETHNLAELEVAHRLGAEIIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEE
VNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
CCCCCEEEEEEEECCCCCCCHHHHCCCEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHH
ENVAQRIKELQIDKG
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQEFLARILEQKAHEVEQMKLEQIQPLRQTYRLAEFLKNHQDRLQVIAEVKKASPSLGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
INLDVDIVQQAQTYEENGTVMISVLTDEVFFKGHLNYLREISSQVEIPTLNKDFIIDEKQ
CCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHH
IIRARNAGATVILLIVAALSEERLKKLYDYATELGLEVLVETHNLAELEVAHRLGAEIIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEE
VNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
CCCCCEEEEEEEECCCCCCCHHHHCCCEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHH
ENVAQRIKELQIDKG
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA