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The map label for this gene is trpA

Identifier: 225859581

GI number: 225859581

Start: 1738760

End: 1739536

Strand: Reverse

Name: trpA

Synonym: SP70585_1872

Alternate gene names: 225859581

Gene position: 1739536-1738760 (Counterclockwise)

Preceding gene: 225859582

Following gene: 225859580

Centisome position: 79.62

GC content: 44.92

Gene sequence:

>777_bases
ATGCCTAAGACACTAACAGAAAAATTAAATGCTATTAAAGCAGCTGGAAAAGGAATTTTTGTTCCCTATATCATGGCTGG
TGACCACGAGAAAGGTTTGGACGGTCTTGCTGAAACAATTCACTTTTTAGAAGATTTGGGTGTCTCTGCAATTGAAGTGG
GTATTCCCTTTTCAGACCCTGTTGCAGATGGACCTGTTATCGAAGAAGCTGGCTTGCGCAGTTTAGCCCACGGGACCTCT
ACCCAGGCTTTAGTTGAAACCTTGAAAACCATTGAAACAGAGATTCCACTGGTCATCATGACCTACTTCAACCCCCTCTT
TCAGTACGGTGTGGAGAACTTTGTCAAAGATCTGGCTGATACAGCTGTGAAGGGCTTGATTATCCCAGACCTGCCTCATG
AACATGCCAACTTTGTAGAACCATTTTTGGCAAATACAGATATCGCCTTGATTCCTTTAGTAAGCTTGACCACAGGAATT
GAGCGCCAGAAAGAGTTGATTGAAGGGGCGGAGGGATTCATCTATGCCGTTGCCATCAATGGAGTGACAGGGAAATCAGG
CAATTACCGTGCAGATTTGGACAAGCACTTGGCGCAACTTCATCAAGTGGCCGACATCCCAGTCTTGACAGGTTTTGGTG
TATCTAGTCAAGCCGATCTGGAACGCTTCAATGCGGTGTCAGATGGTGTTATCGTCGGTTCGAAAATAGTAAAAGCTCTC
CACCAAGGAGAGCCGATTCAGGACTTTATCAAACAAGCAGTAGCTTACCAAAAATAA

Upstream 100 bases:

>100_bases
GAAAAGTCTATGATTGTCTGCCTATCAGGTCGTGGGGACAAGGATGTGGTTCAAGTCAAGGACCGCTTGGAAGCAGATGC
AGCAAAGAAGGGAGAAGCTC

Downstream 100 bases:

>100_bases
TCAAACAAGTAGCAAGTAAGAGGAAAGGCACGAAAGGAAGTCTTTCCTTTTTCTTTTGCAGGAGAAAGGCTAGTTTTATA
GTGAATTGAATCTGGAATAT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTS
TQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLANTDIALIPLVSLTTGI
ERQKELIEGAEGFIYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKAL
HQGEPIQDFIKQAVAYQK

Sequences:

>Translated_258_residues
MPKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTS
TQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLANTDIALIPLVSLTTGI
ERQKELIEGAEGFIYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKAL
HQGEPIQDFIKQAVAYQK
>Mature_257_residues
PKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTST
QALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLANTDIALIPLVSLTTGIE
RQKELIEGAEGFIYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKALH
QGEPIQDFIKQAVAYQK

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=236, Percent_Identity=29.6610169491525, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321412, Length=244, Percent_Identity=34.0163934426229, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 27711; Mature: 27580

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDP
CCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCC
VADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLAD
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TAVKGLIIPDLPHEHANFVEPFLANTDIALIPLVSLTTGIERQKELIEGAEGFIYAVAIN
HHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
GVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKAL
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCEEHHHHHHHHH
HQGEPIQDFIKQAVAYQK
HCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PKTLTEKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDP
CCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCC
VADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLAD
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TAVKGLIIPDLPHEHANFVEPFLANTDIALIPLVSLTTGIERQKELIEGAEGFIYAVAIN
HHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
GVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKAL
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCEEHHHHHHHHH
HQGEPIQDFIKQAVAYQK
HCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA