| Definition | Streptococcus pneumoniae 70585, complete genome. |
|---|---|
| Accession | NC_012468 |
| Length | 2,184,682 |
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The map label for this gene is murC
Identifier: 225859278
GI number: 225859278
Start: 1434923
End: 1436257
Strand: Reverse
Name: murC
Synonym: SP70585_1560
Alternate gene names: 225859278
Gene position: 1436257-1434923 (Counterclockwise)
Preceding gene: 225859279
Following gene: 225859277
Centisome position: 65.74
GC content: 41.72
Gene sequence:
>1335_bases ATGTCAAAGACATATCATTTTATCGGAATTAAGGGATCAGGGATGAGTGCCTTGGCCTTGATGTTGCACCAGATGGGGCA CAAGGTTCAGGGATCAGATGTTGAAAAGTACTACTTTACCCAACGCGGTCTTGAGCAGGCAGGAATTACCATTCTTCCTT TTGATGAAAAAAATCTAGACGGTGATATGGAAATTATCGCTGGAAATGCCTTTCGTCCAGATAACAACGTCGAAATTGCC TATGCGGACCAAAATGGTATCAGCTACAAACGTTACCATGAGTTTCTAGGTAGCTTTATGCGTGACTTTGTTAGCATGGG AGTAGCAGGAGCACATGGAAAAACTTCAACGACAGGTATGTTGTCTCATGTCTTGTCTCACATTACAGATACCAGCTTCT TGATTGGAGATGGGACAGGTCGTGGTTCGGCCAATGCCAAATATTTTGTCTTTGAATCTGACGAATATGAGCGTCACTTC ATGCCTTACCACCCAGAATACTCTATTATCACCAACATTGACTTTGACCATCCAGATTATTTCACAAGTCTCGAGGATGT TTTTAATGCCTTTAACGACTATGCCAAACAAATCACCAAGGGTCTTTTTGTCTATGGTGAAGATGCTGAATTGCGTAAGA TTACGTCTGATGCACCAATTTATTATTATGGTTTTGAAGCTGAAGGCAATGACTTTGTAGCTAGTGATCTTCTTCGTTCA ATAACTGGTTCAACCTTCACCGTTCATTTCCGTGGACAAAACTTGGGGCAATTCCACATTCCAACCTTTGGTCGTCACAA TATCATGAATGCGACAGCCGTTATTGGTCTTCTTTACACAGCAGGATTTGATTTGAACTTGGTGCGTGAGCACTTGAAAA CATTTGCCGGTGTTAAACGTCGTTTCACTGAGAAAATTGTCAATGATACAGTGATTATCGATGACTTTGCCCACCATCCA ACAGAAATTATTGCGACCTTGGATGCGGCTCGTCAGAAATACCCAAGCAAGGAAATTGTAGCAGTCTTTCAACCGCATAC CTTTACAAGAACCATTGCCTTGTTGGACGACTTTGCCCATGCTTTAAACCAAGCAGATGCTGTTTATCTAGCGCAAATTT ATGGCTCGGCTCGTGAAGTAGATCATGGTGACGTTAAGGTAGAAGACCTAGCCAACAAAATCAACAAAAAACACCAAGTG ATTACTGTTGAAAATGTTTCTCCACTCCTAGACCATGACAATGCTGTTTACGTCTTTATGGGAGCAGGAGACATCCAAAC CTATGAATACTCATTTGAGCGTCTCTTGTCTAACTTGACAAGCAATGTTCAATAG
Upstream 100 bases:
>100_bases AAGAGCCAAATCTACAATAAAAAAAGTAAACAAACAGAACAAGAACGTCGGGTTGCCCAAGAGTTGAATCTGACCAGAAT GACAGAATAGGGGAGAAAAC
Downstream 100 bases:
>100_bases GATGTTCCCATGGAAATTCCAATTAAGATCATTCAGGCAAGCAAGTCTGATTTGCCTGAGATAGGGGCACTTCAGACCTC GTCTTTTCCAGCTGAAAAGC
Product: UDP-N-acetylmuramate--L-alanine ligase
Products: NA
Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]
Number of amino acids: Translated: 444; Mature: 443
Protein sequence:
>444_residues MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIA YADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRS ITGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHP TEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQV ITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ
Sequences:
>Translated_444_residues MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIA YADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRS ITGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHP TEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQV ITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ >Mature_443_residues SKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIAY ADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHFM PYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRSI TGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHPT EIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQVI TVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ
Specific function: Cell wall formation [H]
COG id: COG0773
COG function: function code M; UDP-N-acetylmuramate-alanine ligase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family [H]
Homologues:
Organism=Escherichia coli, GI1790680, Length=388, Percent_Identity=30.6701030927835, Blast_Score=156, Evalue=3e-39, Organism=Escherichia coli, GI1786279, Length=455, Percent_Identity=29.6703296703297, Blast_Score=133, Evalue=2e-32,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR016040 - InterPro: IPR005758 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.8 [H]
Molecular weight: Translated: 49887; Mature: 49755
Theoretical pI: Translated: 5.61; Mature: 5.61
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLD CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHCCCEEEECCCCCCC GDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGM CCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH LSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHFMPYHPEYSIITNIDFDHPDY HHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHH FTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRS HHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH ITGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKR HCCCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH RFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAH HHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH ALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQVITVENVSPLLDHDNAVYVFM HHCCCCHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCCEEEEEECCCCHHHCCCCEEEEEE GAGDIQTYEYSFERLLSNLTSNVQ ECCCCCHHHHHHHHHHHHHHHCCC >Mature Secondary Structure SKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFDEKNLD CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHCCCEEEECCCCCCC GDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRDFVSMGVAGAHGKTSTTGM CCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH LSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHFMPYHPEYSIITNIDFDHPDY HHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHH FTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDAPIYYYGFEAEGNDFVASDLLRS HHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH ITGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIGLLYTAGFDLNLVREHLKTFAGVKR HCCCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH RFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKYPSKEIVAVFQPHTFTRTIALLDDFAH HHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH ALNQADAVYLAQIYGSAREVDHGDVKVEDLANKINKKHQVITVENVSPLLDHDNAVYVFM HHCCCCHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCCEEEEEECCCCHHHCCCCEEEEEE GAGDIQTYEYSFERLLSNLTSNVQ ECCCCCHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA