Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 225859042

GI number: 225859042

Start: 1217590

End: 1218288

Strand: Reverse

Name: rnc

Synonym: SP70585_1310

Alternate gene names: 225859042

Gene position: 1218288-1217590 (Counterclockwise)

Preceding gene: 225859043

Following gene: 225859041

Centisome position: 55.77

GC content: 40.92

Gene sequence:

>699_bases
ATGAAAGAATTACAAACTGTACTAAAGAACCATTTTGCAATCGAATTTACAGACAAAAAGTTACTGGAAACTGCCTTTAC
TCATACGAGTTATGCCAATGAGCACCGCCTCTTAAAAATTTCACACAATGAACGCTTGGAATTTTTAGGAGACGCTGTTC
TACAGTTATTGATTTCAGAATATCTATATAAAAAATATCCTAAAAAGCCTGAAGGTGACCTATCAAAACTCCGTGCTATG
ATTGTCCGTGAGGAGAGTTTAGCTGGTTTTGCGCGTGATTGCCAGTTTGACCAGTTTATCAAGTTGGGTAAAGGGGAAGA
AAAATCTGGTGGTCGCAATCGTGACACCATTCTTGGTGATGCCTTTGAAGCCTTTCTTGGTGCCCTTCTTTTGGATAAGG
ATGTGGCCAAGGTCAAGGAATTTATCTATCAAGTCATGATTCCTAAGGTTGAAGCAGGCGAGTTTGAGATGATTACAGAC
TATAAAACCCATCTCCAAGAGTTGCTTCAGGTCAATGGTGATGTGGCTATTCGTTATCAGGTGATTTCTGAAACAGGGCC
TGCTCACGATAAGGTCTTTGATGTAGAAGTTCTTGTTGAAGGTAAGAGCATCGGTCAAGGCCAAGGTCGTTCTAAGAAAT
TAGCAGAGCAGGAAGCTGCCAAAAATGCCGTTGAGAAGGGGCTGGATTCATGTATTTAA

Upstream 100 bases:

>100_bases
TAAAGAATTCCCAAATGCTTTCCAGTCCCGTTTTAGAGTGACTCAGGGGGCTTTTTTTGATATAATAAAAAGGACTATTA
TCAGTTAGAAAGAGGTTGGT

Downstream 100 bases:

>100_bases
AGGAAATCGAAATTCAGGGGTTCAAGTCTTTTGCTGATAAGACCAAGGTCGTTTTTGACCAAGGTGTGACGGCAGTTGTT
GGACCCAATGGATCTGGAAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKELQTVLKNHFAIEFTDKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAM
IVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI

Sequences:

>Translated_232_residues
MKELQTVLKNHFAIEFTDKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAM
IVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI
>Mature_232_residues
MKELQTVLKNHFAIEFTDKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAM
IVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=230, Percent_Identity=32.1739130434783, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=32.1739130434783, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI1788920, Length=211, Percent_Identity=37.914691943128, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=30.6666666666667, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=30.6666666666667, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323895, Length=198, Percent_Identity=29.2929292929293, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17137682, Length=239, Percent_Identity=33.8912133891213, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26198; Mature: 26198

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELQTVLKNHFAIEFTDKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISE
CHHHHHHHHHCCEEEECHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
YLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHH
AFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITDYKTHLQELLQVNGDVAIRYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
VISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI
EECCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKELQTVLKNHFAIEFTDKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISE
CHHHHHHHHHCCEEEECHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
YLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHH
AFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITDYKTHLQELLQVNGDVAIRYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
VISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI
EECCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA