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The map label for this gene is fps [H]

Identifier: 225858990

GI number: 225858990

Start: 1165421

End: 1166296

Strand: Reverse

Name: fps [H]

Synonym: SP70585_1255

Alternate gene names: 225858990

Gene position: 1166296-1165421 (Counterclockwise)

Preceding gene: 225858991

Following gene: 225858989

Centisome position: 53.39

GC content: 44.29

Gene sequence:

>876_bases
ATGAAAAAGCAAGAAAAATTAGCTCTTGTCGAGTCGGCTTTGGAAGATTTTTATGGAGACCAGCAGTTTGCCTCTAGTTT
ACGGGAGTCTGTTCTCTATTCTATTCATGCTGGTGGCAAGCGTATTCGGCCTTTTCTCTTGTTAGAAGTTCTGGAAGCCT
TGCAGGTTACCATCAAACCTGCTCACGCGCAGGTAGCTACTGCCTTGGAGATGATTCATACAGGGAGCTTGATTCACGAT
GACCTTCCTGCTATGGATGATGACGATTATCGAAGAGGGCGGTTAACCAATCACAAGAAATTCGGTGAAGCTATGGCCAT
TTTGGCTGGAGATGCCTTATTCTTAGACTCATATGCCTTGATTGCGCAGGCAGATTTGCCAAGTCAGATTAAGGTGGACT
TGATTGCCAACTTATCCCTTGCTTCAGGTAGTCTGGGTATGGTGGCAGGGCAAGTTTTGGATATGGAGGGCGAACACCAG
CACTTGTCTTTGGAAGAACTTCAGACTATTCATGCCAATAAGACTGGGAAGTTACTAGCCTATCCCTTCCAAGCGGCAGC
TATTATAGCTGAATTGTCACCTGAAATGCAGGTGAAGCTGAAAACTGTGGGTGAATTGATTGGACTTGCTTTTCAAGTCA
GAGATGATGTACTGGATGTGACAGCTAGTTTTGAGGAAATCGGCAAGACACCTCAAAAGGATCTGCAGGCAGAAAAATCA
ACCTATCCTGCCCTGTTGGGCTTGGAAGAGTCCATTGCCTTTTGTAACCAAACCCTGGATCAAGCTAATGAAAAATTAGA
AGAAATTGCCCAGCAGATTCCCTTTGAAACAGAATCGATTGTAAGTGTAGTAGAAAGTTTGAGAATCAATGGCTAA

Upstream 100 bases:

>100_bases
AGGGCATGGTCTTGTCAAAAGAGCTCCAAGCTACGCTGGACAAGGCTGAAAAGACCTTGGTCAAGGTCATGCAAGAAGAC
GGAACAGAAAGTGATTTTGA

Downstream 100 bases:

>100_bases
GGAAAGAGTGGATGTACTAGCTTATAAACAGGGGTTGTTTGAAACGAGAGAGCAGGCCAAGCGAGGTGTGATGGCTGGCC
TAGTCGTAGCAGTCCTTAAT

Product: geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase)

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHD
DLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQIPFETESIVSVVESLRING

Sequences:

>Translated_291_residues
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHD
DLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQIPFETESIVSVVESLRING
>Mature_291_residues
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHD
DLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQIPFETESIVSVVESLRING

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=235, Percent_Identity=29.3617021276596, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1786623, Length=248, Percent_Identity=43.9516129032258, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789578, Length=248, Percent_Identity=31.8548387096774, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=274, Percent_Identity=26.6423357664234, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508563, Length=223, Percent_Identity=29.1479820627803, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24651612, Length=240, Percent_Identity=30, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31869; Mature: 31869

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVTIKP
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
AHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDSYAL
HHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLSLEELQTIHANKTGKLLA
HHCCCCCCCEEHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEE
YPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
ECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQIPFETESIVSVVESLRING
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVTIKP
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
AHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDSYAL
HHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLSLEELQTIHANKTGKLLA
HHCCCCCCCEEHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEE
YPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
ECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQIPFETESIVSVVESLRING
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]