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The map label for this gene is pphA [C]

Identifier: 225858986

GI number: 225858986

Start: 1161785

End: 1162513

Strand: Reverse

Name: pphA [C]

Synonym: SP70585_1251

Alternate gene names: 225858986

Gene position: 1162513-1161785 (Counterclockwise)

Preceding gene: 225858987

Following gene: 225858985

Centisome position: 53.21

GC content: 44.03

Gene sequence:

>729_bases
ATGACAGATTATTATGTAATTGGAGATGTTCACGGAAAAGCTGGGATGCTGGAAGACCTTCTTAAAACCTGGGATGGTCA
GACCCAGTTGCTCTTTCTAGGTGATTTGATTGACAGAGGTGAGGATAGTCACCGTGTTCTTGAAATGGTCAAGGACTTGG
TGGACAATCAAGGGGCTATCTGTTTGTCCGGAAACCACGAGTATATGTTTTTGACTTGGCTAGATGACCCAGAAGAAAGT
TATGACCATTATCGTCGCAATGGTGGAGATACAACCATTAACTCTATCCTAGGTCGTCCCTTGGATGCACCAGTTGATGG
AGTAGAAGATGCCAAGCGGGTTGCCGCTGAAGCGGCAGACTTGGTCGAATTCATTCGTCAAATGCCATTTGTAGTAGAGA
CAGACAAGTATATCTTTGTTCACGCAGGTATTGATTTGACCTTGGACGACTGGCATGAAACAACAGATTATAAAAAAGTA
TGGCTTAGAAAACCATTCCACGGAGCTGAAAATCATACTGGAAAAACCATTGTCTTCGGTCATACACCGGTCTATGGTTT
GTTACAGCAAGAACGCGGTACATCTGAGCTTTGGACTACAGAAGATGGCAAGATTGGAATGGATGGAGGAGCTGTTTATG
GTGGTGTCCTTCACGGGATTGTCTTTACAGACCAAGGAATGACAGAACACCACTTTATCGAAAATGACGGCTTTGTCGCT
GAAGATTAG

Upstream 100 bases:

>100_bases
GAGCGAGTGGAGGAAGTTGCCAAGATGTTGGCAGGTGATGATGTGACAGAAGCAGCCCTGACGCAAGCCAGAGAATTGTT
GAGAAACAGGGAGAAATAAG

Downstream 100 bases:

>100_bases
TACTCCTAGCAGGGTATGGTCTTGTCAAAATATCAAAAACAATTTATAATAAATAGATACCCTGAAAGGAAGAGAATCAT
GAACTTAGAAGAATTGAAAA

Product: serine/threonine protein phosphatase

Products: A Protein; Orthophosphate. [C]

Alternate protein names: Serine/Threonine Protein Phosphatase; Bis(5Nucleosyl)-Tetraphosphatase ApaH; Serine/Threonine Protein Phosphatase Family Protein; Serine/Threonine Specific Protein Phosphatase Protein; Phosphatase; Ser/Thr Protein Phosphatase Family Protein; Diadenosine Tetraphosphatase-Like Protein; Calcineurin-Like Phosphoesterase; Serine-Threonine Protein Phosphatase; Serine/Threonine Protein Phosphatase I; Diadenosine Tetraphosphatase; Serinethreonine Protein Phosphatase; Phosphoprotein Phosphatase; Serine/Threonine Specific Protein Phosphatase; Bis(5-Nucleosyl)-Tetraphosphatase; Serine/Threonine Phosphatase; Serine/Threonine-Protein Phosphatase

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSHRVLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEES
YDHYRRNGGDTTINSILGRPLDAPVDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKV
WLRKPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVFTDQGMTEHHFIENDGFVA
ED

Sequences:

>Translated_242_residues
MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSHRVLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEES
YDHYRRNGGDTTINSILGRPLDAPVDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKV
WLRKPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVFTDQGMTEHHFIENDGFVA
ED
>Mature_241_residues
TDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSHRVLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEESY
DHYRRNGGDTTINSILGRPLDAPVDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKVW
LRKPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVFTDQGMTEHHFIENDGFVAE
D

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 27220; Mature: 27088

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSHRVLEMVKDLVDNQGAI
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEHHHHCCCCHHHHHHHHHHHHCCCCCE
CLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLDAPVDGVEDAKRVAAEAAD
EEECCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKVWLRKPFHGAENHTGKTIVFG
HHHHHHHCCEEEECCCEEEEEECCEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEE
HTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVFTDQGMTEHHFIENDGFVA
CCCHHHHHHHCCCCCCCEECCCCCEECCCCHHHHHHHHEEEEECCCCCHHEEECCCCEEE
ED
CC
>Mature Secondary Structure 
TDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSHRVLEMVKDLVDNQGAI
CCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEHHHHCCCCHHHHHHHHHHHHCCCCCE
CLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLDAPVDGVEDAKRVAAEAAD
EEECCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKVWLRKPFHGAENHTGKTIVFG
HHHHHHHCCEEEECCCEEEEEECCEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEE
HTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVFTDQGMTEHHFIENDGFVA
CCCHHHHHHHCCCCCCCEECCCCCEECCCCHHHHHHHHEEEEECCCCCHHEEECCCCEEE
ED
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA