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The map label for this gene is gor

Identifier: 225858592

GI number: 225858592

Start: 754150

End: 755496

Strand: Reverse

Name: gor

Synonym: SP70585_0827

Alternate gene names: 225858592

Gene position: 755496-754150 (Counterclockwise)

Preceding gene: 225858610

Following gene: 225858591

Centisome position: 34.58

GC content: 43.88

Gene sequence:

>1347_bases
ATGAGAGAATATGATATCATTGCTATCGGTGGAGGTAGCGGAGGAATCGCTACCATGAACCGTGCTGGTGAACATGGAGC
CCAAGCAGCCGTTATTGAGGAAAAGAAATTAGGTGGAACCTGTGTCAACGTCGGTTGTGTTCCTAAAAAAATCATGTGGT
ACGGGGCACAAATCGCTGAGACTTTCCATCAATTTGGAGAAGACTACGGCTTTAAGACTACTGATCTTAACTTTGACTTT
GCAACCCTACGTCGCAATCGTGAATCCTACATTGATCGCGCTCGTTCTTCTTATGATGGCAGTTTTAAACGCAACGGTGT
AGACTTGATTGAAGGTCATGCTGAATTTGTAGATTCTCATACTGTAAGCGTAAATGGTGAACTGATTCGTGCTAAACATA
TCGTGATTGCTACAGGTGCCCATCCAAGTATTCCTAATATTCCTGGTGCTGAGCTAGGTGGCTCTTCTGATGATGTATTT
GCCTGGGAAGAACTTCCAGAGTCAGTTGCCATTCTAGGCGCTGGTTATATCGCCGTTGAATTAGCTGGCGTACTCCACAC
TTTTGGTGTCAAGACAGATCTCTTTGTTCGCCGCGATCGTCCTTTACGTGGTTTTGATTCCTACATCGTTGAAGGTTTGG
TCAAGGAAATGGAAAGAACAAACTTACCACTTCACACTCACAAAGTCCCTGTCAAGTTAGAAAAAACTACTGACGGCATT
ACCATTCATTTCGAAGATGGTACTAGTCACACAGCTAGCCAAGTTATCTGGGCTACAGGCCGCCGTCCAAACGTTAAGGG
CTTGCAACTTGAAAAAGCTGGAGTGACTCTGAACGAACGTGGCTTTATCCAAGTGGATGAATACCAAAATACTGTTGTTG
AGGGAATCTATGCTCTAGGTGATGTAACGGGCGAGAAAGAACTGACTCCAGTTGCAATCAAGGCCGGACGTACCCTATCT
GAACGTCTCTTTAACGGAAAAACTACTGCAAAAATGGATTACTCAACTATTCCAACTGTTGTCTTTTCACACCCTGCTAT
CGGAACTGTTGGTTTGACAGAAGAGCAAGCTATTAAAGAATACGGTCAAGACCAAATCAAGGTTTACAAATCAAGCTTTG
CATCTATGTACTCTGCTTGCACTCGCAACCGTCAAGAATCCCGTTTCAAACTCATAACAGCTGGTTCAGAAGAAAAAGTT
GTCGGACTTCATGGAATTGGCTACGGCGTTGATGAAATGATTCAGGGATTTGCCGTTGCTATCAAAATGGGAGTAACCAA
GGCTGACTTTGACGCAACTGTAGCGATTCACCCAACTTCATCTGAAGAATTTGTAACCATGCGTTAA

Upstream 100 bases:

>100_bases
TTTGTGCGTAGCAGATTTTTGCAATCAAATCAAAAAAAGAATAAAATATAACTATCAAAAAAGACGCTCTACTATTTAAA
AGATTACAAAGGAGTTTTCA

Downstream 100 bases:

>100_bases
TCGAAACAAAAGAAGCTGATATAAATATGTCTGCTTCTTTTTTAATGATTTTCGAATCAACAAAAAAATTATCCAACTTG
ACTAGTCACGAAAATCGGCT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MREYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFDF
ATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVF
AWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGI
TIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLS
ERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKV
VGLHGIGYGVDEMIQGFAVAIKMGVTKADFDATVAIHPTSSEEFVTMR

Sequences:

>Translated_448_residues
MREYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFDF
ATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVF
AWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGI
TIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLS
ERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKV
VGLHGIGYGVDEMIQGFAVAIKMGVTKADFDATVAIHPTSSEEFVTMR
>Mature_448_residues
MREYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFDF
ATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVF
AWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGI
TIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLS
ERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKV
VGLHGIGYGVDEMIQGFAVAIKMGVTKADFDATVAIHPTSSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=49.0196078431373, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=36.2869198312236, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI148277071, Length=431, Percent_Identity=34.338747099768, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI148277065, Length=431, Percent_Identity=34.338747099768, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI33519430, Length=431, Percent_Identity=34.338747099768, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI33519428, Length=431, Percent_Identity=34.338747099768, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI33519426, Length=431, Percent_Identity=34.338747099768, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI291045266, Length=433, Percent_Identity=33.9491916859122, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI291045268, Length=433, Percent_Identity=30.715935334873, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=28.0777537796976, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1789915, Length=448, Percent_Identity=60.9375, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=29.490022172949, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=28.0701754385965, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=28.2560706401766, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=49.8891352549889, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=49.8891352549889, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=35.5932203389831, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=33.4719334719335, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=27.3318872017354, Blast_Score=158, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=44.8275862068966, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=28.051391862955, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=24.0506329113924, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=36.864406779661, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=36.864406779661, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=36.864406779661, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=34.7457627118644, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=28.322440087146, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48890; Mature: 48890

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNVGCVPKKIMWYGAQIAE
CCCEEEEEEECCCCCEEECCCCCCCCCCEEEEEHHCCCCEEEECCCCCHHHHHHHHHHHH
TFHQFGEDYGFKTTDLNFDFATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSH
HHHHHHHHCCCEEECCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEECCHHHHHCCE
TVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVFAWEELPESVAILGAGYIAVE
EEEECCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEHHHCCCCEEHHCCCHHHHH
LAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGI
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCE
TIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALG
EEEEECCCCCCCCEEEEECCCCCCCCCEEEECCCCEECCCCCEEEHHHHHHHHHHHHHHH
DVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKE
CCCCCCCCCEEEEECCCHHHHHHHCCCCEEEECCCCCCEEEECCCCCCCCCCCHHHHHHH
YGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQGFAVA
HCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHEE
IKMGVTKADFDATVAIHPTSSEEFVTMR
HEECCEECCCCEEEEEECCCCCCEEEEC
>Mature Secondary Structure
MREYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNVGCVPKKIMWYGAQIAE
CCCEEEEEEECCCCCEEECCCCCCCCCCEEEEEHHCCCCEEEECCCCCHHHHHHHHHHHH
TFHQFGEDYGFKTTDLNFDFATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSH
HHHHHHHHCCCEEECCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEECCHHHHHCCE
TVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVFAWEELPESVAILGAGYIAVE
EEEECCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEHHHCCCCEEHHCCCHHHHH
LAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGI
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCE
TIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALG
EEEEECCCCCCCCEEEEECCCCCCCCCEEEECCCCEECCCCCEEEHHHHHHHHHHHHHHH
DVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKE
CCCCCCCCCEEEEECCCHHHHHHHCCCCEEEECCCCCCEEEECCCCCCCCCCCHHHHHHH
YGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQGFAVA
HCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHEE
IKMGVTKADFDATVAIHPTSSEEFVTMR
HEECCEECCCCEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8525054 [H]