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The map label for this gene is pepA [H]

Identifier: 225853605

GI number: 225853605

Start: 2121171

End: 2122553

Strand: Reverse

Name: pepA [H]

Synonym: BMEA_A2241

Alternate gene names: 225853605

Gene position: 2122553-2121171 (Counterclockwise)

Preceding gene: 225853607

Following gene: 225853604

Centisome position: 99.85

GC content: 63.41

Gene sequence:

>1383_bases
ATGTCCGCCGAAATCATTTCCCAAAAATCCGCCGCCAGCCGCCCCATCTGGTTTGTCGCCAAGAACGCGCTGGATGAAGC
CGCCCTTCCCGAAAGCGCCGCTGCCTGGGCGAAGGCCAATGGCTTCGATGGTGAAGCCGGGCGTGTGCTGGTGCTGCCGG
GGCGCGATGGCGCGATTGCGGGCGCCCTGTTTGGCACCGGCGAGGCGCCGGAGAACGGCCAGCCGCAGCTTATCGCCGGA
AAGCTTGCCCGCAACCTGCCGGAAGGCGATTGGCATATTGAAGGCAAGCCGGGCGATGCCGGTCTTGCCGCACTCGCTTT
CCTGATGGGCGGTTATAGTTTCACACGCTATCGCAAGGCTAATGGCAAGACGGTCCGCCTGGCCCTGCCCGAAGGCGCGG
ACGCTTCTGAAACACGCCGTCTGGCAGAAGCCGTCACGCTCGTGCGCGATCTCATCAACACACCCGCCAACGACATGGGG
CCGGCGGCGCTGGAGCAGGCCGCACGCGATCTGGCGGCACAGCATGGCGCGCGGGTGGCAACCACGGAAGGCGAAGCGCT
TCTGGAAAAGAATTTCCCCATGATCCATGCGGTTGGCCGTGCAGGTGCCGTGGCCCCGCGCCTGATCGACCTTCAATGGG
GGCGGGACAGCGATCCGAAGATCACGCTTGTCGGCAAGGGCGTCTGTTTCGATACGGGCGGTCTCGACATCAAATCCGCA
AGCGGGATGCTGCTGATGAAGAAGGACATGGGCGGCGCGGCCAATGTGCTGGGTCTTGCCGCACTCATCATGGATGCGAA
ACTGCCGGTACGGCTGCGCGTGCTCATTCCCGCGATAGAAAACGCAATCGCGGGCAATGCTTTCCGCCCCGGCGACATTC
TGCAAAGCCGCAAGGGGCTGACCGTTGAAATCGGCAATACCGATGCCGAGGGCCGTCTGGTTCTGGCCGATGCGCTGGCG
CTTGCCGACGAAGAAGAGCCGGAAATGCTGATCGACATGGCAACGCTGACGGGCGCGGCCCGCGTGGCGCTGGGGCCGGA
TCTTCCGCCCTTCTATACGCATGACGACCAGCTTGCGGGCGAAATCGCCGTAAAGGCCAGAGAGACCGCCGACCCTCTAT
GGCGGATGCCGCTCTGGCAGCCCTATGCGCAAAAGCTTTCCTCGCGCGTGGCCGATATCAACAATGTCACCACGGACGGT
TTCGCCGGTTCCGTGACAGCGGCACTGTTTCTCGCCAAATTCGTCAAGAGGGCACGCCAATGGGCGCATTTCGACATTTT
CGGCTGGGTGCCGGTCGAAAAGCCTGCCTCCCCCGTTGGCGGCGAAGCGCAGGCCATCCGCGCCCTTTACCAGCTTTTGA
AGGAACGTTATCCGGCCCGCTGA

Upstream 100 bases:

>100_bases
CTTCGCGACAATAAGAAACTAGGTTCAAGCCGGTTTGCATATGCAGGCCGGCTTTTGTGTTTTCCCTTGAATCCAACTTT
CCATTGCCGAGAGATTTGCG

Downstream 100 bases:

>100_bases
AAATGCTTGCCTGCGCGGCCAAAAGCGGGTTGAATAAAACGGTTCCGAAACAATCCCTGTTTTGATGGAGCCGGATGCCG
ATAGAGCTGAAGCCGTTACA

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSAEIISQKSAASRPIWFVAKNALDEAALPESAAAWAKANGFDGEAGRVLVLPGRDGAIAGALFGTGEAPENGQPQLIAG
KLARNLPEGDWHIEGKPGDAGLAALAFLMGGYSFTRYRKANGKTVRLALPEGADASETRRLAEAVTLVRDLINTPANDMG
PAALEQAARDLAAQHGARVATTEGEALLEKNFPMIHAVGRAGAVAPRLIDLQWGRDSDPKITLVGKGVCFDTGGLDIKSA
SGMLLMKKDMGGAANVLGLAALIMDAKLPVRLRVLIPAIENAIAGNAFRPGDILQSRKGLTVEIGNTDAEGRLVLADALA
LADEEEPEMLIDMATLTGAARVALGPDLPPFYTHDDQLAGEIAVKARETADPLWRMPLWQPYAQKLSSRVADINNVTTDG
FAGSVTAALFLAKFVKRARQWAHFDIFGWVPVEKPASPVGGEAQAIRALYQLLKERYPAR

Sequences:

>Translated_460_residues
MSAEIISQKSAASRPIWFVAKNALDEAALPESAAAWAKANGFDGEAGRVLVLPGRDGAIAGALFGTGEAPENGQPQLIAG
KLARNLPEGDWHIEGKPGDAGLAALAFLMGGYSFTRYRKANGKTVRLALPEGADASETRRLAEAVTLVRDLINTPANDMG
PAALEQAARDLAAQHGARVATTEGEALLEKNFPMIHAVGRAGAVAPRLIDLQWGRDSDPKITLVGKGVCFDTGGLDIKSA
SGMLLMKKDMGGAANVLGLAALIMDAKLPVRLRVLIPAIENAIAGNAFRPGDILQSRKGLTVEIGNTDAEGRLVLADALA
LADEEEPEMLIDMATLTGAARVALGPDLPPFYTHDDQLAGEIAVKARETADPLWRMPLWQPYAQKLSSRVADINNVTTDG
FAGSVTAALFLAKFVKRARQWAHFDIFGWVPVEKPASPVGGEAQAIRALYQLLKERYPAR
>Mature_459_residues
SAEIISQKSAASRPIWFVAKNALDEAALPESAAAWAKANGFDGEAGRVLVLPGRDGAIAGALFGTGEAPENGQPQLIAGK
LARNLPEGDWHIEGKPGDAGLAALAFLMGGYSFTRYRKANGKTVRLALPEGADASETRRLAEAVTLVRDLINTPANDMGP
AALEQAARDLAAQHGARVATTEGEALLEKNFPMIHAVGRAGAVAPRLIDLQWGRDSDPKITLVGKGVCFDTGGLDIKSAS
GMLLMKKDMGGAANVLGLAALIMDAKLPVRLRVLIPAIENAIAGNAFRPGDILQSRKGLTVEIGNTDAEGRLVLADALAL
ADEEEPEMLIDMATLTGAARVALGPDLPPFYTHDDQLAGEIAVKARETADPLWRMPLWQPYAQKLSSRVADINNVTTDGF
AGSVTAALFLAKFVKRARQWAHFDIFGWVPVEKPASPVGGEAQAIRALYQLLKERYPAR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=342, Percent_Identity=34.7953216374269, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI47155554, Length=292, Percent_Identity=33.9041095890411, Blast_Score=129, Evalue=6e-30,
Organism=Escherichia coli, GI87082123, Length=356, Percent_Identity=39.8876404494382, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1790710, Length=285, Percent_Identity=39.2982456140351, Blast_Score=183, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=301, Percent_Identity=36.8770764119601, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=235, Percent_Identity=31.063829787234, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24661038, Length=288, Percent_Identity=35.0694444444444, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21355725, Length=288, Percent_Identity=34.375, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI221379063, Length=299, Percent_Identity=35.1170568561873, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221379062, Length=299, Percent_Identity=35.1170568561873, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21357381, Length=299, Percent_Identity=35.1170568561873, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355645, Length=325, Percent_Identity=26.7692307692308, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24662223, Length=325, Percent_Identity=26.7692307692308, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20129969, Length=291, Percent_Identity=28.5223367697594, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24662227, Length=291, Percent_Identity=26.8041237113402, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922386, Length=324, Percent_Identity=27.7777777777778, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161077148, Length=416, Percent_Identity=28.125, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI20130057, Length=416, Percent_Identity=28.125, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI20129963, Length=322, Percent_Identity=27.9503105590062, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646701, Length=201, Percent_Identity=32.3383084577114, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646703, Length=201, Percent_Identity=32.3383084577114, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358201, Length=201, Percent_Identity=32.3383084577114, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 48743; Mature: 48612

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEIISQKSAASRPIWFVAKNALDEAALPESAAAWAKANGFDGEAGRVLVLPGRDGAIA
CCCHHHCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCEE
GALFGTGEAPENGQPQLIAGKLARNLPEGDWHIEGKPGDAGLAALAFLMGGYSFTRYRKA
EEEECCCCCCCCCCCCEEHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCHHEEEEEC
NGKTVRLALPEGADASETRRLAEAVTLVRDLINTPANDMGPAALEQAARDLAAQHGARVA
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEE
TTEGEALLEKNFPMIHAVGRAGAVAPRLIDLQWGRDSDPKITLVGKGVCFDTGGLDIKSA
ECCCHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCEEECC
SGMLLMKKDMGGAANVLGLAALIMDAKLPVRLRVLIPAIENAIAGNAFRPGDILQSRKGL
CCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCHHHHHCCCCC
TVEIGNTDAEGRLVLADALALADEEEPEMLIDMATLTGAARVALGPDLPPFYTHDDQLAG
EEEECCCCCCCCEEEEEHHHHCCCCCCHHEEEHHHHCCCEEEEECCCCCCCCCCCHHHCC
EIAVKARETADPLWRMPLWQPYAQKLSSRVADINNVTTDGFAGSVTAALFLAKFVKRARQ
CEEEEEHHCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WAHFDIFGWVPVEKPASPVGGEAQAIRALYQLLKERYPAR
CCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAEIISQKSAASRPIWFVAKNALDEAALPESAAAWAKANGFDGEAGRVLVLPGRDGAIA
CCHHHCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCEE
GALFGTGEAPENGQPQLIAGKLARNLPEGDWHIEGKPGDAGLAALAFLMGGYSFTRYRKA
EEEECCCCCCCCCCCCEEHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCHHEEEEEC
NGKTVRLALPEGADASETRRLAEAVTLVRDLINTPANDMGPAALEQAARDLAAQHGARVA
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEE
TTEGEALLEKNFPMIHAVGRAGAVAPRLIDLQWGRDSDPKITLVGKGVCFDTGGLDIKSA
ECCCHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCEEECC
SGMLLMKKDMGGAANVLGLAALIMDAKLPVRLRVLIPAIENAIAGNAFRPGDILQSRKGL
CCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCHHHHHCCCCC
TVEIGNTDAEGRLVLADALALADEEEPEMLIDMATLTGAARVALGPDLPPFYTHDDQLAG
EEEECCCCCCCCEEEEEHHHHCCCCCCHHEEEHHHHCCCEEEEECCCCCCCCCCCHHHCC
EIAVKARETADPLWRMPLWQPYAQKLSSRVADINNVTTDGFAGSVTAALFLAKFVKRARQ
CEEEEEHHCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WAHFDIFGWVPVEKPASPVGGEAQAIRALYQLLKERYPAR
CCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]