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The map label for this gene is gyaR [H]

Identifier: 225853601

GI number: 225853601

Start: 2118125

End: 2119129

Strand: Direct

Name: gyaR [H]

Synonym: BMEA_A2237

Alternate gene names: 225853601

Gene position: 2118125-2119129 (Clockwise)

Preceding gene: 225853599

Following gene: 225853606

Centisome position: 99.64

GC content: 60.4

Gene sequence:

>1005_bases
ATGTCGAACAAGAAGAAGCCGATGGTCGTTCTTACGAGAAAACTGCCGGACCCGGTGGAAACCCGAATGAGGGAACTGTT
CGATGCGCGTCTGAACATAGACGATCACCGCATGAGCCAGCCGGAAATCATCGCTGCCCTGAAGGAAGCTGATGTTCTGG
TGCCCTGCATCACCGATGTCATCGACGCAGCGGTCATCGAACAGGCAGGACCAAATCTGAAGCTGATCGCCAATTTTGGC
AACGGCGTGGATAATATCGATGTAGCTGCCGCCGCCAGGCGCGGCATCACCGTCACCAATACGCCCAATGTTCTGACCGA
AGACACTGCCGACATGACGCTGGCGCTGCTTTTGTCGGTGCCGCGCCGCCTCGTGGAAGGTGCAAATGTCATCAATGAGC
GCCATGGCCAGTGGCCGGGCTGGTCGCCCACATGGATGCTCGGACGCCGCATCTGGGGCAAACGTCTCGGCATTGTGGGC
ATGGGGCGCATCGGAACGGCGGTTGCCCGCCGCGCCAAGGCCTTTGGCCTCTCGATCCATTATCACAATCGCAAGCGCGT
CAGCCCGCAGGTTGAGGAAGAGCTGGAGGCGACCTATTGGGACAGCCTCGACCAGATGCTGGCCCGCATGGACATCATCT
CGGTCAATTGCCCGTCCACGCCCGCGACCTTCCACCTGCTTTCCGCCCGCCACATTGCGCTGATGCAGCCGACCGCCTAT
CTGGTCAACACGGCGCGCGGCCAGATCATCGATGAAAATGCGCTGATCGACCTTATCGAAGAGGGCAGGCTGGCCGGTGC
CGGGCTGGATGTCTTCGAGCATGAGCCAGCCGTCAATCCGCGCCTGCTGGCACTGGCCGAAAAGGGCAAGGTGGTGCTTC
TGCCGCATATGGGATCGGCCACGATAGAAGGCCGTATCGATATGGGCGACAAGGTCATCATCAATATTCGTGCCTTCGTG
GACGGCCACCGTTCGCCCGATCGCGTGCTGCCCAACCGGGTCTGA

Upstream 100 bases:

>100_bases
GGGATTCCGTTTCCATGGGGAAATGTGCAGGAAATTATCGGGACGTCCGTTTGGTCATTGTGGCGGCGTTCTGAAGGCAT
TCTCAAATGACGGGGTGGAA

Downstream 100 bases:

>100_bases
GGCCGGGTCTGAGACGGGATCAGCTTATGGCCCGTCGATGAATCGCAGCACCGCACGGGTCACGACGGTATCATGATCCC
CGATCACGATAGCGGTGCGA

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSNKKKPMVVLTRKLPDPVETRMRELFDARLNIDDHRMSQPEIIAALKEADVLVPCITDVIDAAVIEQAGPNLKLIANFG
NGVDNIDVAAAARRGITVTNTPNVLTEDTADMTLALLLSVPRRLVEGANVINERHGQWPGWSPTWMLGRRIWGKRLGIVG
MGRIGTAVARRAKAFGLSIHYHNRKRVSPQVEEELEATYWDSLDQMLARMDIISVNCPSTPATFHLLSARHIALMQPTAY
LVNTARGQIIDENALIDLIEEGRLAGAGLDVFEHEPAVNPRLLALAEKGKVVLLPHMGSATIEGRIDMGDKVIINIRAFV
DGHRSPDRVLPNRV

Sequences:

>Translated_334_residues
MSNKKKPMVVLTRKLPDPVETRMRELFDARLNIDDHRMSQPEIIAALKEADVLVPCITDVIDAAVIEQAGPNLKLIANFG
NGVDNIDVAAAARRGITVTNTPNVLTEDTADMTLALLLSVPRRLVEGANVINERHGQWPGWSPTWMLGRRIWGKRLGIVG
MGRIGTAVARRAKAFGLSIHYHNRKRVSPQVEEELEATYWDSLDQMLARMDIISVNCPSTPATFHLLSARHIALMQPTAY
LVNTARGQIIDENALIDLIEEGRLAGAGLDVFEHEPAVNPRLLALAEKGKVVLLPHMGSATIEGRIDMGDKVIINIRAFV
DGHRSPDRVLPNRV
>Mature_333_residues
SNKKKPMVVLTRKLPDPVETRMRELFDARLNIDDHRMSQPEIIAALKEADVLVPCITDVIDAAVIEQAGPNLKLIANFGN
GVDNIDVAAAARRGITVTNTPNVLTEDTADMTLALLLSVPRRLVEGANVINERHGQWPGWSPTWMLGRRIWGKRLGIVGM
GRIGTAVARRAKAFGLSIHYHNRKRVSPQVEEELEATYWDSLDQMLARMDIISVNCPSTPATFHLLSARHIALMQPTAYL
VNTARGQIIDENALIDLIEEGRLAGAGLDVFEHEPAVNPRLLALAEKGKVVLLPHMGSATIEGRIDMGDKVIINIRAFVD
GHRSPDRVLPNRV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=324, Percent_Identity=32.4074074074074, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI23308577, Length=294, Percent_Identity=32.312925170068, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI61743967, Length=264, Percent_Identity=34.469696969697, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4557497, Length=264, Percent_Identity=34.469696969697, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI145580578, Length=260, Percent_Identity=33.4615384615385, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI4557499, Length=260, Percent_Identity=33.4615384615385, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=33.4615384615385, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI87082289, Length=332, Percent_Identity=38.5542168674699, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1789279, Length=268, Percent_Identity=33.955223880597, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787645, Length=203, Percent_Identity=29.064039408867, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI87081824, Length=294, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788660, Length=315, Percent_Identity=26.031746031746, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=289, Percent_Identity=30.4498269896194, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=209, Percent_Identity=34.4497607655502, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=37.0967741935484, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=323, Percent_Identity=28.4829721362229, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=267, Percent_Identity=30.3370786516854, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=286, Percent_Identity=30.0699300699301, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=263, Percent_Identity=28.5171102661597, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=31.6091954022989, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=149, Percent_Identity=30.8724832214765, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571528, Length=329, Percent_Identity=37.0820668693009, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28574286, Length=307, Percent_Identity=34.2019543973941, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=36.8, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI28574284, Length=273, Percent_Identity=34.4322344322344, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45551003, Length=273, Percent_Identity=34.4322344322344, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24585514, Length=273, Percent_Identity=34.4322344322344, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28574282, Length=273, Percent_Identity=34.4322344322344, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19921140, Length=304, Percent_Identity=31.5789473684211, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646446, Length=226, Percent_Identity=37.6106194690265, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24646448, Length=226, Percent_Identity=37.6106194690265, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24646452, Length=226, Percent_Identity=37.6106194690265, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24646450, Length=226, Percent_Identity=37.6106194690265, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI62472511, Length=226, Percent_Identity=37.6106194690265, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24585516, Length=286, Percent_Identity=29.7202797202797, Blast_Score=127, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36858; Mature: 36727

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKKKPMVVLTRKLPDPVETRMRELFDARLNIDDHRMSQPEIIAALKEADVLVPCITDV
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHCCCHHHHHHHH
IDAAVIEQAGPNLKLIANFGNGVDNIDVAAAARRGITVTNTPNVLTEDTADMTLALLLSV
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHH
PRRLVEGANVINERHGQWPGWSPTWMLGRRIWGKRLGIVGMGRIGTAVARRAKAFGLSIH
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHEEEEE
YHNRKRVSPQVEEELEATYWDSLDQMLARMDIISVNCPSTPATFHLLSARHIALMQPTAY
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEHHHCEEEEECCHHH
LVNTARGQIIDENALIDLIEEGRLAGAGLDVFEHEPAVNPRLLALAEKGKVVLLPHMGSA
HHCCCCCCEECCHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEEEECCCCEEEEECCCCE
TIEGRIDMGDKVIINIRAFVDGHRSPDRVLPNRV
EEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SNKKKPMVVLTRKLPDPVETRMRELFDARLNIDDHRMSQPEIIAALKEADVLVPCITDV
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHCCCHHHHHHHH
IDAAVIEQAGPNLKLIANFGNGVDNIDVAAAARRGITVTNTPNVLTEDTADMTLALLLSV
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHH
PRRLVEGANVINERHGQWPGWSPTWMLGRRIWGKRLGIVGMGRIGTAVARRAKAFGLSIH
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHEEEEE
YHNRKRVSPQVEEELEATYWDSLDQMLARMDIISVNCPSTPATFHLLSARHIALMQPTAY
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEHHHCEEEEECCHHH
LVNTARGQIIDENALIDLIEEGRLAGAGLDVFEHEPAVNPRLLALAEKGKVVLLPHMGSA
HHCCCCCCEECCHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEEEECCCCEEEEECCCCE
TIEGRIDMGDKVIINIRAFVDGHRSPDRVLPNRV
EEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA