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The map label for this gene is glmU [H]

Identifier: 225853529

GI number: 225853529

Start: 2041349

End: 2042068

Strand: Direct

Name: glmU [H]

Synonym: BMEA_A2162

Alternate gene names: 225853529

Gene position: 2041349-2042068 (Clockwise)

Preceding gene: 225853528

Following gene: 225853530

Centisome position: 96.03

GC content: 59.17

Gene sequence:

>720_bases
ATGAAAATGCCTGAAACCGCAATGGTTCTTGCCGCCGGTCTTGGCAAGCGTATGCGTCCCATCACCGAAACCATGCCGAA
GCCGCTGGTGAACGTCGCGGGCAAGCCGCTGATCGACTGGTGCCTCGATGCGGTAGAGCGGGCAGGGGTGGCCCGTGCAA
TCGTCAATGTGCATTATTTAGCCGACCAGCTTGAGCACCATCTTGCGACCCGCAACCGTCCGCAGATTATCATTTCCGAC
GAACGCGGCCTTCTTCTCGATTCGGCGGGCGGTATCGTCAAGGTACTGCCGGATCTGGTTGGAGAGCCCTTCTTCATCTT
GAATGCGGATACGTTCTGGGTCGGGGATGAGGCCGAACCCAATCTCGTCAGGCTTGCCGAAACATGGGATGATGCCCGCA
TGGACATCCTGTTGATGACGGCACGGCTCGATCAGGAAACGGGCTATGAAGGCAAGGGTGATTTTGTTGCCGATGCCGAA
GGCCGCCTGCGCCGTGCACGCGATGTCCCGGGCGAACCGGTGATCTATGCGGGTGCCGGTATCATTCACCCGCGCATCTT
TGCCGATGCGACACCCGGCATTGCTTCGCTCAATTGCCATTTCGATCAGGCAATCGCCGCAGGCCGTCTTTATGGGATGC
CCATGACCGGGCACTGGCTGACGGTGGGAACACCGGAAGCCATCGGCAAGGCAGAGGCCGTGTTGTCCGCATTTGCATGA

Upstream 100 bases:

>100_bases
ATCCATGATTATCTGGGGCGTGTTCTCAAACATCCGGTCATGGCCCCCGTCGCGGCATGGTTCAAGGCACTCGGATTGAT
GCAGGAAGGGACGGTGCACA

Downstream 100 bases:

>100_bases
GGGAGGCAAGCAGCATGTGCGCATCGCGGCCCGGAGATGGAAAACAGCGCCTGTTTTCCATTCCTCCCGGCCAGCCCTTC
CTGCCCGCTTTCGCAAAGGC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKMPETAMVLAAGLGKRMRPITETMPKPLVNVAGKPLIDWCLDAVERAGVARAIVNVHYLADQLEHHLATRNRPQIIISD
ERGLLLDSAGGIVKVLPDLVGEPFFILNADTFWVGDEAEPNLVRLAETWDDARMDILLMTARLDQETGYEGKGDFVADAE
GRLRRARDVPGEPVIYAGAGIIHPRIFADATPGIASLNCHFDQAIAAGRLYGMPMTGHWLTVGTPEAIGKAEAVLSAFA

Sequences:

>Translated_239_residues
MKMPETAMVLAAGLGKRMRPITETMPKPLVNVAGKPLIDWCLDAVERAGVARAIVNVHYLADQLEHHLATRNRPQIIISD
ERGLLLDSAGGIVKVLPDLVGEPFFILNADTFWVGDEAEPNLVRLAETWDDARMDILLMTARLDQETGYEGKGDFVADAE
GRLRRARDVPGEPVIYAGAGIIHPRIFADATPGIASLNCHFDQAIAAGRLYGMPMTGHWLTVGTPEAIGKAEAVLSAFA
>Mature_239_residues
MKMPETAMVLAAGLGKRMRPITETMPKPLVNVAGKPLIDWCLDAVERAGVARAIVNVHYLADQLEHHLATRNRPQIIISD
ERGLLLDSAGGIVKVLPDLVGEPFFILNADTFWVGDEAEPNLVRLAETWDDARMDILLMTARLDQETGYEGKGDFVADAE
GRLRRARDVPGEPVIYAGAGIIHPRIFADATPGIASLNCHFDQAIAAGRLYGMPMTGHWLTVGTPEAIGKAEAVLSAFA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=229, Percent_Identity=28.3842794759825, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI11761621, Length=229, Percent_Identity=28.3842794759825, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=238, Percent_Identity=28.1512605042017, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21355443, Length=229, Percent_Identity=29.2576419213974, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644084, Length=229, Percent_Identity=29.2576419213974, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 25902; Mature: 25902

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPETAMVLAAGLGKRMRPITETMPKPLVNVAGKPLIDWCLDAVERAGVARAIVNVHYL
CCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHH
ADQLEHHLATRNRPQIIISDERGLLLDSAGGIVKVLPDLVGEPFFILNADTFWVGDEAEP
HHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCEEEEECCEEEECCCCCC
NLVRLAETWDDARMDILLMTARLDQETGYEGKGDFVADAEGRLRRARDVPGEPVIYAGAG
CEEEEEHHCCCCCEEEEEEEECCCHHCCCCCCCCEEECCHHHHHHHHCCCCCCEEEECCC
IIHPRIFADATPGIASLNCHFDQAIAAGRLYGMPMTGHWLTVGTPEAIGKAEAVLSAFA
EECCEEECCCCCCEEEEECCHHHHHHHCEEECCCCCCCEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKMPETAMVLAAGLGKRMRPITETMPKPLVNVAGKPLIDWCLDAVERAGVARAIVNVHYL
CCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHH
ADQLEHHLATRNRPQIIISDERGLLLDSAGGIVKVLPDLVGEPFFILNADTFWVGDEAEP
HHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCEEEEECCEEEECCCCCC
NLVRLAETWDDARMDILLMTARLDQETGYEGKGDFVADAEGRLRRARDVPGEPVIYAGAG
CEEEEEHHCCCCCEEEEEEEECCCHHCCCCCCCCEEECCHHHHHHHHCCCCCCEEEECCC
IIHPRIFADATPGIASLNCHFDQAIAAGRLYGMPMTGHWLTVGTPEAIGKAEAVLSAFA
EECCEEECCCCCCEEEEECCHHHHHHHCEEECCCCCCCEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]