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The map label for this gene is hslU [H]

Identifier: 225853510

GI number: 225853510

Start: 2021265

End: 2022569

Strand: Reverse

Name: hslU [H]

Synonym: BMEA_A2141

Alternate gene names: 225853510

Gene position: 2022569-2021265 (Counterclockwise)

Preceding gene: 225853511

Following gene: 225853509

Centisome position: 95.15

GC content: 59.85

Gene sequence:

>1305_bases
ATGAGCAATTTTTCTCCCCGTGAAATCGTTTCGGAGCTTGACCGCTTCATCATCGGCCAGAAGGACGCCAAGCGCGCGGT
GGCCATTGCGCTGCGCAATCGCTGGCGCCGCCAGCAGCTTGAAGGGCAGATGCGCGAAGAGGTCATGCCGAAGAATATCC
TGATGATCGGGCCGACCGGCGTGGGCAAAACGGAAATCTCGCGCCGTCTGGCCAAGCTTGCAGGCGCGCCCTTCGTCAAG
GTGGAGGCCACCAAATTTACCGAAGTGGGCTATGTCGGCCGCGATGTGGAGCAGATCATCCGCGATCTGGTCGAGATCGC
CATCGCGCTTGTGCGTGAAAAGCGCCGCGAGGACGTGAAGGCCAAGGCGCATCTCAACGCCGAGGAACGGGTTCTGGACG
CGCTCGTGGGCAAGACGGCCAGCCCCGTCACCCGTGACAGCTTCCGCAAGAAGCTGCGCAATGGCGAGATGGACGACAAG
GAAATCGAGATCGAGGTTTCCGATTCCGGCGCCAGCCCGAACTTCGAGATTCCCGGCATGCCGGGCGCGAATATCGGCGT
GCTCAATATTTCCGACATGCTGGGCAAGGCCATGGGCGGGCGCACCAAGACGCGCAAGACCACGGTGAAGGATTCCTACC
CCATCCTCATCAATGACGAATCCGACAAGCTGCTCGATCAGGACCAGATCGTGCAGGAGGCGCTGCGTGTGAGCGAGGAT
GAAGGCATCGTCTTCATCGATGAGATTGACAAGATCGCCGCGCGCGAAGGCGGGAGCGGGGCAGGCGTCTCGCGTGAAGG
CGTGCAGCGCGACCTGCTACCGCTTGTCGAAGGCACAACGGTCGCGACCAAATACGGGCCGGTGAAGACGGATCACATTC
TTTTCATCACCTCAGGCGCGTTCCATGTCTCCAAGCCATCCGATCTTCTGCCGGAATTGCAGGGCCGCCTGCCCATCCGC
GTGGAACTTTCCGCGCTGACGCGGGAGGATTTCCGCCGCATTCTGACGGAAACCGAGGCAAGCCTCATCAAGCAGTATAT
TGCGCTCATGGAAACGGAAGAGGTGAAGCTTGAATTCTCCGACGACGCGATTGATGCGCTGGCCGATATCGCGGTCGATC
TCAACGCGACGGTGGAGAATATCGGCGCCCGCCGCCTGCAAACCGTGATGGAGAAGGTGCTGGACGAAATTTCCTTCACC
GCGCCGGACAAGGCCGGAGCAACCTTCATCATCGACGCAGCCTATGTGAAGGAGAAGATCGGCGGCCTTGCCAAAAACAC
CGATCTTTCGCGCTTCATTCTTTAA

Upstream 100 bases:

>100_bases
ATCGTCGAAAGCCTCGACGCGCAGTGAGATCTGCCGCCAGCCAATCTCCTCACCATATCGCCGCCGCCTGGTGACGGCGG
CAACAGGGATTTGACAAGAA

Downstream 100 bases:

>100_bases
AACAGCTCATGACGTGACCGGAAAGCCACGGGCATCCGCCCGCTTTTGCCGGCCATGCAAAAACCCCTCGACTTGCATCG
GGGGGTTTTCTATTTTCCCG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSNFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVK
VEATKFTEVGYVGRDVEQIIRDLVEIAIALVREKRREDVKAKAHLNAEERVLDALVGKTASPVTRDSFRKKLRNGEMDDK
EIEIEVSDSGASPNFEIPGMPGANIGVLNISDMLGKAMGGRTKTRKTTVKDSYPILINDESDKLLDQDQIVQEALRVSED
EGIVFIDEIDKIAAREGGSGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHILFITSGAFHVSKPSDLLPELQGRLPIR
VELSALTREDFRRILTETEASLIKQYIALMETEEVKLEFSDDAIDALADIAVDLNATVENIGARRLQTVMEKVLDEISFT
APDKAGATFIIDAAYVKEKIGGLAKNTDLSRFIL

Sequences:

>Translated_434_residues
MSNFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVK
VEATKFTEVGYVGRDVEQIIRDLVEIAIALVREKRREDVKAKAHLNAEERVLDALVGKTASPVTRDSFRKKLRNGEMDDK
EIEIEVSDSGASPNFEIPGMPGANIGVLNISDMLGKAMGGRTKTRKTTVKDSYPILINDESDKLLDQDQIVQEALRVSED
EGIVFIDEIDKIAAREGGSGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHILFITSGAFHVSKPSDLLPELQGRLPIR
VELSALTREDFRRILTETEASLIKQYIALMETEEVKLEFSDDAIDALADIAVDLNATVENIGARRLQTVMEKVLDEISFT
APDKAGATFIIDAAYVKEKIGGLAKNTDLSRFIL
>Mature_433_residues
SNFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVKV
EATKFTEVGYVGRDVEQIIRDLVEIAIALVREKRREDVKAKAHLNAEERVLDALVGKTASPVTRDSFRKKLRNGEMDDKE
IEIEVSDSGASPNFEIPGMPGANIGVLNISDMLGKAMGGRTKTRKTTVKDSYPILINDESDKLLDQDQIVQEALRVSEDE
GIVFIDEIDKIAAREGGSGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHILFITSGAFHVSKPSDLLPELQGRLPIRV
ELSALTREDFRRILTETEASLIKQYIALMETEEVKLEFSDDAIDALADIAVDLNATVENIGARRLQTVMEKVLDEISFTA
PDKAGATFIIDAAYVKEKIGGLAKNTDLSRFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=446, Percent_Identity=57.1748878923767, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1786642, Length=114, Percent_Identity=42.1052631578947, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648289, Length=242, Percent_Identity=29.3388429752066, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648291, Length=242, Percent_Identity=29.3388429752066, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 47956; Mature: 47824

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTG
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAGAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAIALVREKRREDVK
CCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAHLNAEERVLDALVGKTASPVTRDSFRKKLRNGEMDDKEIEIEVSDSGASPNFEIPGM
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
PGANIGVLNISDMLGKAMGGRTKTRKTTVKDSYPILINDESDKLLDQDQIVQEALRVSED
CCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHCCHHHHHHHHHHCCCC
EGIVFIDEIDKIAAREGGSGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHILFITSGA
CCEEEEECHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCC
FHVSKPSDLLPELQGRLPIRVELSALTREDFRRILTETEASLIKQYIALMETEEVKLEFS
EECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
DDAIDALADIAVDLNATVENIGARRLQTVMEKVLDEISFTAPDKAGATFIIDAAYVKEKI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHH
GGLAKNTDLSRFIL
CCCCCCCCHHHHCC
>Mature Secondary Structure 
SNFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAGAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAIALVREKRREDVK
CCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAHLNAEERVLDALVGKTASPVTRDSFRKKLRNGEMDDKEIEIEVSDSGASPNFEIPGM
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
PGANIGVLNISDMLGKAMGGRTKTRKTTVKDSYPILINDESDKLLDQDQIVQEALRVSED
CCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHCCHHHHHHHHHHCCCC
EGIVFIDEIDKIAAREGGSGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHILFITSGA
CCEEEEECHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCC
FHVSKPSDLLPELQGRLPIRVELSALTREDFRRILTETEASLIKQYIALMETEEVKLEFS
EECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
DDAIDALADIAVDLNATVENIGARRLQTVMEKVLDEISFTAPDKAGATFIIDAAYVKEKI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHH
GGLAKNTDLSRFIL
CCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA