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The map label for this gene is aqpZ [H]

Identifier: 225853437

GI number: 225853437

Start: 1943257

End: 1943943

Strand: Direct

Name: aqpZ [H]

Synonym: BMEA_A2060

Alternate gene names: 225853437

Gene position: 1943257-1943943 (Clockwise)

Preceding gene: 225853436

Following gene: 225853438

Centisome position: 91.42

GC content: 58.52

Gene sequence:

>687_bases
ATGTTGAACAAATTATCGGCTGAATTTTTCGGAACATTCTGGCTGGTCTTCGGAGGGTGCGGCAGCGCGATTCTCGCCGC
CGCTTTCCCTGAACTGGGTATCGGCTTCCTCGGTGTTGCCCTTGCTTTCGGTTTAACCGTCCTCACCATGGCCTATGCTG
TTGGCGGCATTTCCGGCGGACATTTCAACCCCGCCGTATCGCTCGGCCTCACCGTTGCCGGGCGTCTTCCGGCCAAGGAT
CTGATTCCCTATTGGGTCGCGCAGGTTCTGGGAGCCATCGCCGCTGCTGCCATCCTCTATGTCATTGCTTCTGGCAAAGA
TGGCTTCTCGGCTGGAGGTCTCGCCTCGAACGGTTATGGTGAGCTTTCTCCCGGCGGCTACAGCATGATGGCCGGCCTGC
TCATCGAAATCATCCTGACGGCCTTCTTCATCATCATCATTCTGGGCTCGACTTCGTCGCTTGCACCAGCGGGTTTCGCC
CCGATTGCGATCGGCTTTGGCCTCACCCTCATCCATCTGGTCTCCATTCCGGTTACCAATACGTGGGTAAACCCGGCGCG
CTCGACCGGCGTTGCCCTCTTCGCCGATACGGCAGCCCTCAGCCAGCTCTGGCTTTTCTGGGTTGCACCACTTGTAGGCG
CGGTAATCGGTGCAATCATCTGGAAGGGCCTGCTCGGCCGAGATTAA

Upstream 100 bases:

>100_bases
AGAATCTAAACGATATTGCTGCAATAAATATGCGACTATATATTCTTGGATACCTGATTCGCATACTTGCCGTATCACTA
CACGAACTCTGGGGATTTCC

Downstream 100 bases:

>100_bases
TCAGAAGGGGTAGTCTCGGTATTTGATGGGCCGGATTCGAATAGCATCGATCCGGCTCACAATCCGGGCCTGCGCTGTTT
TAGAGCGCATCCCGAAAAGT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: Aquaporin X [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MLNKLSAEFFGTFWLVFGGCGSAILAAAFPELGIGFLGVALAFGLTVLTMAYAVGGISGGHFNPAVSLGLTVAGRLPAKD
LIPYWVAQVLGAIAAAAILYVIASGKDGFSAGGLASNGYGELSPGGYSMMAGLLIEIILTAFFIIIILGSTSSLAPAGFA
PIAIGFGLTLIHLVSIPVTNTWVNPARSTGVALFADTAALSQLWLFWVAPLVGAVIGAIIWKGLLGRD

Sequences:

>Translated_228_residues
MLNKLSAEFFGTFWLVFGGCGSAILAAAFPELGIGFLGVALAFGLTVLTMAYAVGGISGGHFNPAVSLGLTVAGRLPAKD
LIPYWVAQVLGAIAAAAILYVIASGKDGFSAGGLASNGYGELSPGGYSMMAGLLIEIILTAFFIIIILGSTSSLAPAGFA
PIAIGFGLTLIHLVSIPVTNTWVNPARSTGVALFADTAALSQLWLFWVAPLVGAVIGAIIWKGLLGRD
>Mature_228_residues
MLNKLSAEFFGTFWLVFGGCGSAILAAAFPELGIGFLGVALAFGLTVLTMAYAVGGISGGHFNPAVSLGLTVAGRLPAKD
LIPYWVAQVLGAIAAAAILYVIASGKDGFSAGGLASNGYGELSPGGYSMMAGLLIEIILTAFFIIIILGSTSSLAPAGFA
PIAIGFGLTLIHLVSIPVTNTWVNPARSTGVALFADTAALSQLWLFWVAPLVGAVIGAIIWKGLLGRD

Specific function: Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=226, Percent_Identity=38.4955752212389, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI4502183, Length=227, Percent_Identity=40.0881057268723, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4502179, Length=221, Percent_Identity=34.841628959276, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI6912506, Length=221, Percent_Identity=35.7466063348416, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI4502181, Length=216, Percent_Identity=33.7962962962963, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4755125, Length=228, Percent_Identity=32.4561403508772, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI45446752, Length=202, Percent_Identity=34.6534653465347, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI157266307, Length=238, Percent_Identity=32.7731092436975, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI22538420, Length=245, Percent_Identity=30.6122448979592, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI86792455, Length=228, Percent_Identity=30.7017543859649, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4826645, Length=246, Percent_Identity=29.6747967479675, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1787101, Length=230, Percent_Identity=67.8260869565217, Blast_Score=285, Evalue=2e-78,
Organism=Escherichia coli, GI1790362, Length=247, Percent_Identity=29.5546558704453, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71993722, Length=235, Percent_Identity=33.1914893617021, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17558372, Length=241, Percent_Identity=29.4605809128631, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71992966, Length=234, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17531429, Length=243, Percent_Identity=28.8065843621399, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17531431, Length=243, Percent_Identity=28.8065843621399, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71994009, Length=239, Percent_Identity=29.2887029288703, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992961, Length=232, Percent_Identity=30.1724137931034, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325450, Length=224, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24652747, Length=218, Percent_Identity=33.0275229357798, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551084, Length=218, Percent_Identity=33.0275229357798, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24652751, Length=220, Percent_Identity=35.9090909090909, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922038, Length=220, Percent_Identity=35.9090909090909, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136672, Length=218, Percent_Identity=28.8990825688073, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24762344, Length=232, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24762346, Length=232, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24762348, Length=232, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130305, Length=232, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550503, Length=228, Percent_Identity=25.8771929824561, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762342, Length=188, Percent_Identity=28.1914893617021, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23190; Mature: 23190

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKLSAEFFGTFWLVFGGCGSAILAAAFPELGIGFLGVALAFGLTVLTMAYAVGGISGG
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HFNPAVSLGLTVAGRLPAKDLIPYWVAQVLGAIAAAAILYVIASGKDGFSAGGLASNGYG
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ELSPGGYSMMAGLLIEIILTAFFIIIILGSTSSLAPAGFAPIAIGFGLTLIHLVSIPVTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
TWVNPARSTGVALFADTAALSQLWLFWVAPLVGAVIGAIIWKGLLGRD
CCCCCCHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNKLSAEFFGTFWLVFGGCGSAILAAAFPELGIGFLGVALAFGLTVLTMAYAVGGISGG
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HFNPAVSLGLTVAGRLPAKDLIPYWVAQVLGAIAAAAILYVIASGKDGFSAGGLASNGYG
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ELSPGGYSMMAGLLIEIILTAFFIIIILGSTSSLAPAGFAPIAIGFGLTLIHLVSIPVTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
TWVNPARSTGVALFADTAALSQLWLFWVAPLVGAVIGAIIWKGLLGRD
CCCCCCHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11101683 [H]