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The map label for this gene is lysA [H]

Identifier: 225853419

GI number: 225853419

Start: 1927714

End: 1928979

Strand: Direct

Name: lysA [H]

Synonym: BMEA_A2040

Alternate gene names: 225853419

Gene position: 1927714-1928979 (Clockwise)

Preceding gene: 225853418

Following gene: 225853420

Centisome position: 90.69

GC content: 60.98

Gene sequence:

>1266_bases
GTGAACCACTTTGAATATCGCAACGGCGTTCTCCACGCTGAAAATGTCAGCCTGCCCGAAATAGCCAAGGCCGTCGGCAC
GCCTTTCTATGTCTATTCGCGCGCAACCATCGAGCGCCATTTTCGCGTGTTCCATGACGCCTTTGCCGATATGGACACGC
TCGTCACCTATGCGCTGAAGGCGAATTCCAACCAGGCTGTGCTGACGGCGCTGGCAAAGCTTGGCGCGGGCGCGGACACG
GTTTCGCAGGGCGAGATCCGCCGTGCGCTTGCCGCGGGCATTCCGGCAAACAGGATTGTATTTTCCGGCGTCGGCAAGAC
CCCGCGCGAAATGGATTTTGCGCTGGAAGCTGGCATTTACTGTTTCAACGTCGAATCCGAGCCGGAGCTGGAAATTCTTT
CAGCCCGCGCCGTCGCCGCCGGCAAGGTGGCGCCTGTCTCGCTGCGTATCAACCCGGATGTGGATGCGAAGACCCACGCG
AAAATCTCCACCGGCAAGTCGGAGAACAAGTTCGGCATCCCGCGCGACAAGGCGCGCGCGGCCTATGCCCGCGCGGCAAG
CCTGCCCGGCCTCAACGTCGTCGGCATCGACATGCACATCGGAAGCCAGATCATCGATCTTGAGCCTTTCGACAATGCTT
TCGCGCTGATGGCGGAACTGGTGAAGGAATTGCAGGCCGATGGCCACAATATCCGCCATGTCGATGTGGGCGGCGGGCTG
GGCATTCCCTACCGCACCGACAACACGCCGCCGCCGCCACCTGTTGCCTATGCCCAAATAGTGGCGAAACACATCAAGCC
GCTCGGCCTCAAGACCGTGTTTGAGCCGGGCCGCCTGATCGTCGGCAATGCCGGGCTTCTCGTGACGGAAGTAATTTTCG
TGAAGGAAGGCGATGCGAAGAATTTCGTGATCGTGGACGCGGCGATGAACGATCTCATCCGCCCGACGCTTTACGATGCC
TTTCACGATATCAGGCCGGTCATTATGCCGAACGACAATGCCCCGCGCATCCGCGCCGATTTCGTCGGTCCGGTCTGCGA
GACGGGCGACTATCTGGGCCTCGACCGCGAGGTGGCAAAGCCCGCCCCCGGCGACCTGATCGCCATCTGCACCACCGGCG
CTTATGGCGCGGTGCTTTCCAGCACCTATAACAGCCGCCTTCTCATTCCCGAAGTGCTGGTGGACGGCGAGCGTTACCAT
GTGGTTCGTCCGCGCCGCACCTATGAGGAATTGCTGGCGCTCGATTCCGTGCCGGACTGGCTGTAA

Upstream 100 bases:

>100_bases
AACCGACGATCAGGGTCATACCCAGGAGAAACCGAAGGAAGACAAGCCCTTCATTCTCGACAAGATATTGTAATTCCATC
CCCCTCAAGGGACATTTCCC

Downstream 100 bases:

>100_bases
ATCCCACTATTATAATTCTCATGGCATAGCCTCGCCTTTGCCATGATGCGTGTTATCTTGTTGCGGGATAAAAATGCGAT
ACACGCCAGAAAGGCCAGAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MNHFEYRNGVLHAENVSLPEIAKAVGTPFYVYSRATIERHFRVFHDAFADMDTLVTYALKANSNQAVLTALAKLGAGADT
VSQGEIRRALAAGIPANRIVFSGVGKTPREMDFALEAGIYCFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHA
KISTGKSENKFGIPRDKARAAYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQADGHNIRHVDVGGGL
GIPYRTDNTPPPPPVAYAQIVAKHIKPLGLKTVFEPGRLIVGNAGLLVTEVIFVKEGDAKNFVIVDAAMNDLIRPTLYDA
FHDIRPVIMPNDNAPRIRADFVGPVCETGDYLGLDREVAKPAPGDLIAICTTGAYGAVLSSTYNSRLLIPEVLVDGERYH
VVRPRRTYEELLALDSVPDWL

Sequences:

>Translated_421_residues
MNHFEYRNGVLHAENVSLPEIAKAVGTPFYVYSRATIERHFRVFHDAFADMDTLVTYALKANSNQAVLTALAKLGAGADT
VSQGEIRRALAAGIPANRIVFSGVGKTPREMDFALEAGIYCFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHA
KISTGKSENKFGIPRDKARAAYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQADGHNIRHVDVGGGL
GIPYRTDNTPPPPPVAYAQIVAKHIKPLGLKTVFEPGRLIVGNAGLLVTEVIFVKEGDAKNFVIVDAAMNDLIRPTLYDA
FHDIRPVIMPNDNAPRIRADFVGPVCETGDYLGLDREVAKPAPGDLIAICTTGAYGAVLSSTYNSRLLIPEVLVDGERYH
VVRPRRTYEELLALDSVPDWL
>Mature_421_residues
MNHFEYRNGVLHAENVSLPEIAKAVGTPFYVYSRATIERHFRVFHDAFADMDTLVTYALKANSNQAVLTALAKLGAGADT
VSQGEIRRALAAGIPANRIVFSGVGKTPREMDFALEAGIYCFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHA
KISTGKSENKFGIPRDKARAAYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQADGHNIRHVDVGGGL
GIPYRTDNTPPPPPVAYAQIVAKHIKPLGLKTVFEPGRLIVGNAGLLVTEVIFVKEGDAKNFVIVDAAMNDLIRPTLYDA
FHDIRPVIMPNDNAPRIRADFVGPVCETGDYLGLDREVAKPAPGDLIAICTTGAYGAVLSSTYNSRLLIPEVLVDGERYH
VVRPRRTYEELLALDSVPDWL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=359, Percent_Identity=27.8551532033426, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI16506287, Length=350, Percent_Identity=24.5714285714286, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=422, Percent_Identity=32.9383886255924, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17562780, Length=366, Percent_Identity=22.4043715846995, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24586472, Length=366, Percent_Identity=26.2295081967213, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24586474, Length=358, Percent_Identity=26.2569832402235, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45612; Mature: 45612

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFEYRNGVLHAENVSLPEIAKAVGTPFYVYSRATIERHFRVFHDAFADMDTLVTYALK
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEE
ANSNQAVLTALAKLGAGADTVSQGEIRRALAAGIPANRIVFSGVGKTPREMDFALEAGIY
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCEE
CFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHAKISTGKSENKFGIPRDKARA
EEECCCCCCCEEEEHHHHHCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHH
AYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQADGHNIRHVDVGGGL
HHHHHHCCCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCC
GIPYRTDNTPPPPPVAYAQIVAKHIKPLGLKTVFEPGRLIVGNAGLLVTEVIFVKEGDAK
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCEEEEECCCEEEEEEEEEECCCCC
NFVIVDAAMNDLIRPTLYDAFHDIRPVIMPNDNAPRIRADFVGPVCETGDYLGLDREVAK
CEEEEEHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEHCCCCCHHCCCCCCCCCHHHCC
PAPGDLIAICTTGAYGAVLSSTYNSRLLIPEVLVDGERYHVVRPRRTYEELLALDSVPDW
CCCCCEEEEEECCCHHHHHHHCCCCEEEEHHHHCCCCEEEEECCHHHHHHHHHHCCCCCC
L
C
>Mature Secondary Structure
MNHFEYRNGVLHAENVSLPEIAKAVGTPFYVYSRATIERHFRVFHDAFADMDTLVTYALK
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEE
ANSNQAVLTALAKLGAGADTVSQGEIRRALAAGIPANRIVFSGVGKTPREMDFALEAGIY
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCEE
CFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHAKISTGKSENKFGIPRDKARA
EEECCCCCCCEEEEHHHHHCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHH
AYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQADGHNIRHVDVGGGL
HHHHHHCCCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCC
GIPYRTDNTPPPPPVAYAQIVAKHIKPLGLKTVFEPGRLIVGNAGLLVTEVIFVKEGDAK
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCEEEEECCCEEEEEEEEEECCCCC
NFVIVDAAMNDLIRPTLYDAFHDIRPVIMPNDNAPRIRADFVGPVCETGDYLGLDREVAK
CEEEEEHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEHCCCCCHHCCCCCCCCCHHHCC
PAPGDLIAICTTGAYGAVLSSTYNSRLLIPEVLVDGERYHVVRPRRTYEELLALDSVPDW
CCCCCEEEEEECCCHHHHHHHCCCCEEEEHHHHCCCCEEEEECCHHHHHHHHHHCCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]