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The map label for this gene is sdhA [H]

Identifier: 225853339

GI number: 225853339

Start: 1854933

End: 1856774

Strand: Reverse

Name: sdhA [H]

Synonym: BMEA_A1956

Alternate gene names: 225853339

Gene position: 1856774-1854933 (Counterclockwise)

Preceding gene: 225853340

Following gene: 225853338

Centisome position: 87.35

GC content: 61.78

Gene sequence:

>1842_bases
ATGGCTAGTGCAGTAAACAATGCGGCGCCCGCCGCTGCAAGCAAGTACACCTATGTCGATCACAAGTTCGACGTGGTGGT
GGTCGGAGCCGGCGGCGCGGGCTTGCGCGCAACCCTCGGCATGGCCGAACAGGGCCTCAAGACGGCTTGTATCACCAAGG
TTTTCCCGACCCGCTCGCATACGGTTGCGGCGCAGGGCGGCATCGCCGCTTCGCTCAAGAACATGGGGCCGGATAGCTGG
CAGTGGCATATGTACGACACCGTGAAAGGGTCGGACTGGCTGGGCGATACCGACGCCATGGAATATCTGACCCGCGAAGC
GCCTGCCGCCGTCTACGAGCTTGAGCATTACGGCGTGCCGTTCTCGCGTACGGAAGAAGGCAAGATCTATCAGCGCCCCT
TTGGCGGCCACATGCAGAATTTCGGCGATGGTCCTCCGGTTCAGCGCACCTGCGCTGCTGCCGACCGTACCGGCCATGCC
ATCCTGCATACGCTTTACGGCCAGTCGCTGAAGAACAATGCGCAGTTCTTCATTGAATATTTCGCGCTCGACCTCATCAT
GACCGATGGCGTGTGCACCGGCGTCGTGGCGTGGAACCTCGATGACGGCACGATCCATCGCTTCTCCGCCAAGATGGTGG
TTCTGGCGACGGGCGGCTATGGCCGCGCCTATTTCTCGGCAACCTCTGCCCATACCTGCACCGGCGACGGCGGCGGCATG
GTGGCACGCGCCGGCCTGCCGTTGCAGGACATGGAATTCGTGCAGTTCCACCCGACCGGCATTTATGGCGCGGGCTGCCT
CATCACCGAAGGCGCGCGCGGCGAAGGCGGCTATCTGGTCAATTCCGAAGGCGAACGCTTCATGGAGCGTTATGCCCCCT
CGGCCAAGGACCTTGCCTCGCGAGACGTTGTTTCGCGCTGCATGACGATGGAAATTCGTGCGGGCCGCGGCGTCGGCAAG
AACAAGGACCACATCTACCTGCATCTCGACCATCTCGACCCTGCTGTTCTGCATGAACGCCTGCCGGGCATTTCCGAGTC
GGCCAAGATTTTCGCGGGCGTGGATGTGACCAAGGAACCGATCCCGGTTCTGCCGACCGTTCACTACAATATGGGCGGCA
TTCCGACCAACTATTGGGGCGAAGTGCTGAACCCGACCAAGGAAGACCCGGACCGCGTGCAGCCGGGCCTGATGGCCGTG
GGCGAAGCGGGCTGCGCTTCGGTGCATGGCGCAAACCGTCTCGGCTCCAACTCGCTGATCGATCTCGTGGTGTTCGGCCG
CGCGGCTGCGATCCGCGCCGGTCAGGTCATCGACCGCAAGTCGAAGATCCCGGATATCGATATCGCTGCCTGTGACAAGA
TCATGGAACGCTTCGACCGCCTGCGCTTTGCCAACGGCTCCACGCCGACGGCTGTGCTGCGTGAAAAGATGCAGCGCACC
ATGCAGGAAGATGCCGCCGTGTTCCGCACGGAGGAATCGCTCAAGCAGGGTGTCGAGCGCATGGAAAAGCTCTGGCATGA
ACTGCCGGACATCAAGGTCACAGACCGCTCCATGATCTGGAACTCGGATCTCGTTGAAACGCTGGAACTTGAAAATCTGA
TGGCGAATGCGCTGACGACCGTTGTTTCGGCGGAAGCCCGTCAGGAAAGCCGCGGCGCCCATGCGCGCGAGGATTTCCCG
GACCGCAACGACGCGGAATGGCGCAAGCACACGCTTTCCCGGCTTTCGCCTGACGGCAAGGTCACGCTCGACTATCGTCC
GGTTCATCTCGATCCGCTGACGACGGAAGAGGAAGGTGGCATCAGCCTCGCCAAGATTGCGCCGAAGAAGCGCGTTTACT
GA

Upstream 100 bases:

>100_bases
AAGATCGTGCTGGTGATGCTGAACACCTTCTTTACGGTGGTGGTTGGTCTTGCCTGCGTTTTCGCGATCCTCAAGCTCAG
CTTTGGAGGTTGATGGCCCG

Downstream 100 bases:

>100_bases
TCAGGGGCAAGAGCAATGGTTGAACTCGCACTTCCCAAGAATTCCCGTATGCAGGAGGGCAAGACCTGGCCCCGTCCTGA
TGGCGCCACCCGTGTCACGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MASAVNNAAPAAASKYTYVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLKNMGPDSW
QWHMYDTVKGSDWLGDTDAMEYLTREAPAAVYELEHYGVPFSRTEEGKIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHA
ILHTLYGQSLKNNAQFFIEYFALDLIMTDGVCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGM
VARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIRAGRGVGK
NKDHIYLHLDHLDPAVLHERLPGISESAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNYWGEVLNPTKEDPDRVQPGLMAV
GEAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGQVIDRKSKIPDIDIAACDKIMERFDRLRFANGSTPTAVLREKMQRT
MQEDAAVFRTEESLKQGVERMEKLWHELPDIKVTDRSMIWNSDLVETLELENLMANALTTVVSAEARQESRGAHAREDFP
DRNDAEWRKHTLSRLSPDGKVTLDYRPVHLDPLTTEEEGGISLAKIAPKKRVY

Sequences:

>Translated_613_residues
MASAVNNAAPAAASKYTYVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLKNMGPDSW
QWHMYDTVKGSDWLGDTDAMEYLTREAPAAVYELEHYGVPFSRTEEGKIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHA
ILHTLYGQSLKNNAQFFIEYFALDLIMTDGVCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGM
VARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIRAGRGVGK
NKDHIYLHLDHLDPAVLHERLPGISESAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNYWGEVLNPTKEDPDRVQPGLMAV
GEAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGQVIDRKSKIPDIDIAACDKIMERFDRLRFANGSTPTAVLREKMQRT
MQEDAAVFRTEESLKQGVERMEKLWHELPDIKVTDRSMIWNSDLVETLELENLMANALTTVVSAEARQESRGAHAREDFP
DRNDAEWRKHTLSRLSPDGKVTLDYRPVHLDPLTTEEEGGISLAKIAPKKRVY
>Mature_612_residues
ASAVNNAAPAAASKYTYVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLKNMGPDSWQ
WHMYDTVKGSDWLGDTDAMEYLTREAPAAVYELEHYGVPFSRTEEGKIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHAI
LHTLYGQSLKNNAQFFIEYFALDLIMTDGVCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMV
ARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTMEIRAGRGVGKN
KDHIYLHLDHLDPAVLHERLPGISESAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNYWGEVLNPTKEDPDRVQPGLMAVG
EAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGQVIDRKSKIPDIDIAACDKIMERFDRLRFANGSTPTAVLREKMQRTM
QEDAAVFRTEESLKQGVERMEKLWHELPDIKVTDRSMIWNSDLVETLELENLMANALTTVVSAEARQESRGAHAREDFPD
RNDAEWRKHTLSRLSPDGKVTLDYRPVHLDPLTTEEEGGISLAKIAPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=619, Percent_Identity=61.8739903069467, Blast_Score=742, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=573, Percent_Identity=52.7050610820244, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1790597, Length=586, Percent_Identity=40.7849829351536, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=31.0834813499112, Blast_Score=213, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17550100, Length=606, Percent_Identity=63.2013201320132, Blast_Score=751, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=622, Percent_Identity=59.967845659164, Blast_Score=720, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=613, Percent_Identity=63.6215334420881, Blast_Score=775, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=604, Percent_Identity=64.2384105960265, Blast_Score=769, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=631, Percent_Identity=62.7575277337559, Blast_Score=764, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=631, Percent_Identity=62.7575277337559, Blast_Score=764, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=631, Percent_Identity=62.7575277337559, Blast_Score=764, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=631, Percent_Identity=55.9429477020602, Blast_Score=707, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66963; Mature: 66831

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAVNNAAPAAASKYTYVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSH
CCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCC
TVAAQGGIAASLKNMGPDSWQWHMYDTVKGSDWLGDTDAMEYLTREAPAAVYELEHYGVP
EEEECCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCC
FSRTEEGKIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHAILHTLYGQSLKNNAQFFIEY
CCCCCCCCEEECCCCCCHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
FALDLIMTDGVCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGM
HHHHHHHCCCCEEEEEEEECCCCCEEEEEEEEEEEEECCCCEEEEECCCCCEEECCCCCE
VARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLAS
EEECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHH
RDVVSRCMTMEIRAGRGVGKNKDHIYLHLDHLDPAVLHERLPGISESAKIFAGVDVTKEP
HHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCC
IPVLPTVHYNMGGIPTNYWGEVLNPTKEDPDRVQPGLMAVGEAGCASVHGANRLGSNSLI
CCCCCEEECCCCCCCCHHHHHHCCCCCCCHHHCCCCCEEECCCCCCCCCCCCCCCCCCEE
DLVVFGRAAAIRAGQVIDRKSKIPDIDIAACDKIMERFDRLRFANGSTPTAVLREKMQRT
EEEECCCHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHH
MQEDAAVFRTEESLKQGVERMEKLWHELPDIKVTDRSMIWNSDLVETLELENLMANALTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHH
VVSAEARQESRGAHAREDFPDRNDAEWRKHTLSRLSPDGKVTLDYRPVHLDPLTTEEEGG
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCC
ISLAKIAPKKRVY
EEEEEECCCCCCC
>Mature Secondary Structure 
ASAVNNAAPAAASKYTYVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSH
CCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCC
TVAAQGGIAASLKNMGPDSWQWHMYDTVKGSDWLGDTDAMEYLTREAPAAVYELEHYGVP
EEEECCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCC
FSRTEEGKIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHAILHTLYGQSLKNNAQFFIEY
CCCCCCCCEEECCCCCCHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
FALDLIMTDGVCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGM
HHHHHHHCCCCEEEEEEEECCCCCEEEEEEEEEEEEECCCCEEEEECCCCCEEECCCCCE
VARAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLAS
EEECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHH
RDVVSRCMTMEIRAGRGVGKNKDHIYLHLDHLDPAVLHERLPGISESAKIFAGVDVTKEP
HHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCC
IPVLPTVHYNMGGIPTNYWGEVLNPTKEDPDRVQPGLMAVGEAGCASVHGANRLGSNSLI
CCCCCEEECCCCCCCCHHHHHHCCCCCCCHHHCCCCCEEECCCCCCCCCCCCCCCCCCEE
DLVVFGRAAAIRAGQVIDRKSKIPDIDIAACDKIMERFDRLRFANGSTPTAVLREKMQRT
EEEECCCHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHH
MQEDAAVFRTEESLKQGVERMEKLWHELPDIKVTDRSMIWNSDLVETLELENLMANALTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHH
VVSAEARQESRGAHAREDFPDRNDAEWRKHTLSRLSPDGKVTLDYRPVHLDPLTTEEEGG
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCC
ISLAKIAPKKRVY
EEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA