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The map label for this gene is tesB [H]

Identifier: 225853335

GI number: 225853335

Start: 1850946

End: 1851899

Strand: Reverse

Name: tesB [H]

Synonym: BMEA_A1951

Alternate gene names: 225853335

Gene position: 1851899-1850946 (Counterclockwise)

Preceding gene: 225853337

Following gene: 225853333

Centisome position: 87.12

GC content: 59.43

Gene sequence:

>954_bases
ATGCCTCTTGAACTTTGTAAAGCATATATGGTTGCGGGAGGCAGGCTGTCCATGTCTGATGAAGAAAAGTCCGGGATCGA
GCAGACGGCGGCAATGCGCGAACTGCTGTCGATCCTTGATCTCGAAACGCTTGAAATGGATCTTTTTCGCGGCAACAGCC
CGCAGGTCGGCTGGCAGCGCGTCTTTGGCGGGCAGGTCATCGGGCAGGCGCTGATTGCGGCGCAGCGCACCGTCGATCCC
GAACGCCATGTGCATTCGCTCCACGCCTATTTCGTGCGTCCGGGCGATCCTGCCATTCCCATCATCTATGAGGTGGATCG
CATCCGCGACGGTTCCAGCTTCAGCACCCGCCGCGTGCTGGCCAAGCAGCACGGCAAGGCGATCTTTACGCTTTCCGCTT
CCTTCCAGATCGATGAAGGCGGCCTCGACCATCAAATGCCGATGCCCGAAGGGTTGCCGCAGCCGGAGCAGCTCGTCGGC
GACCATGACATCAAGGAAAAATATCTCGATATGGCACCACCCGGCGTGCGCAAATATTGGGAACGGGAGCGCCCGATCGA
AATCAAGCCGGTCTCGCTCACCCATTATTTCTCGCGCGAGAAGCTGGAGCCGGTGCAGCATGTCTGGGTGCGGGCAAGGG
GGCTTGTCCCTGATGACCGCGCATTGCAGGCCGCCATTCTCGCTTATCTTTCCGATATGACGCTGCTCGATACCTCGCTT
CACCCGCATGGCCGTTTCATTTTCGACCGCGACATGCAGGTAGCGAGCCTTGACCATGCCATGTGGTTCCACCGCCCGTG
CCGGCTGGATGACTGGCTTCTTTATACGCAGGATGCGCCGAGCGCTTCTGGTGCGCGCGGCTTCAATCGTGGCGCGCTTT
ATACGCGCGATGGTGTGCTGATCGCATCGGTGGCGCAGGAAGGGCTGATCCGCGTCCACGAAAAAAACAAGTGA

Upstream 100 bases:

>100_bases
TATTTTGCCGCGCCGCCTGTTCCAGCCCAATCGCTGGTGCGCGAATGTGTTTCCTTTGGCCTGCCCGGTTCTTGACAGGC
CCGGATGTGCAGGCTCAAAC

Downstream 100 bases:

>100_bases
TGGTTATTTAATCAGCAGTTTTTCTGTAGCTTAAATTTTAAGCAGATTGGTGATTGCGCGCAAGGTTTCATCCTTTCCGC
GCATTTCATTTCAGGGAGGA

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MPLELCKAYMVAGGRLSMSDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQRVFGGQVIGQALIAAQRTVDP
ERHVHSLHAYFVRPGDPAIPIIYEVDRIRDGSSFSTRRVLAKQHGKAIFTLSASFQIDEGGLDHQMPMPEGLPQPEQLVG
DHDIKEKYLDMAPPGVRKYWERERPIEIKPVSLTHYFSREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSL
HPHGRFIFDRDMQVASLDHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVLIASVAQEGLIRVHEKNK

Sequences:

>Translated_317_residues
MPLELCKAYMVAGGRLSMSDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQRVFGGQVIGQALIAAQRTVDP
ERHVHSLHAYFVRPGDPAIPIIYEVDRIRDGSSFSTRRVLAKQHGKAIFTLSASFQIDEGGLDHQMPMPEGLPQPEQLVG
DHDIKEKYLDMAPPGVRKYWERERPIEIKPVSLTHYFSREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSL
HPHGRFIFDRDMQVASLDHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVLIASVAQEGLIRVHEKNK
>Mature_316_residues
PLELCKAYMVAGGRLSMSDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQRVFGGQVIGQALIAAQRTVDPE
RHVHSLHAYFVRPGDPAIPIIYEVDRIRDGSSFSTRRVLAKQHGKAIFTLSASFQIDEGGLDHQMPMPEGLPQPEQLVGD
HDIKEKYLDMAPPGVRKYWERERPIEIKPVSLTHYFSREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSLH
PHGRFIFDRDMQVASLDHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVLIASVAQEGLIRVHEKNK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=286, Percent_Identity=45.1048951048951, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI1786657, Length=273, Percent_Identity=48.3516483516484, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71988741, Length=291, Percent_Identity=39.1752577319588, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17558508, Length=308, Percent_Identity=38.3116883116883, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI115532456, Length=314, Percent_Identity=35.6687898089172, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17531889, Length=314, Percent_Identity=35.6687898089172, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17531885, Length=314, Percent_Identity=35.6687898089172, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI212645202, Length=268, Percent_Identity=36.1940298507463, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71982224, Length=272, Percent_Identity=34.5588235294118, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322480, Length=332, Percent_Identity=26.8072289156627, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 35874; Mature: 35742

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLELCKAYMVAGGRLSMSDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQR
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHH
VFGGQVIGQALIAAQRTVDPERHVHSLHAYFVRPGDPAIPIIYEVDRIRDGSSFSTRRVL
HHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHH
AKQHGKAIFTLSASFQIDEGGLDHQMPMPEGLPQPEQLVGDHDIKEKYLDMAPPGVRKYW
HHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCHHHHHH
ERERPIEIKPVSLTHYFSREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSL
HCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHEECCC
HPHGRFIFDRDMQVASLDHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVL
CCCCCEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEE
IASVAQEGLIRVHEKNK
EEEHHHHCCEEEECCCC
>Mature Secondary Structure 
PLELCKAYMVAGGRLSMSDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQR
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHH
VFGGQVIGQALIAAQRTVDPERHVHSLHAYFVRPGDPAIPIIYEVDRIRDGSSFSTRRVL
HHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHH
AKQHGKAIFTLSASFQIDEGGLDHQMPMPEGLPQPEQLVGDHDIKEKYLDMAPPGVRKYW
HHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCHHHHHH
ERERPIEIKPVSLTHYFSREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSL
HCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHEECCC
HPHGRFIFDRDMQVASLDHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVL
CCCCCEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEE
IASVAQEGLIRVHEKNK
EEEHHHHCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]