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The map label for this gene is hemC

Identifier: 225853324

GI number: 225853324

Start: 1839677

End: 1840621

Strand: Reverse

Name: hemC

Synonym: BMEA_A1940

Alternate gene names: 225853324

Gene position: 1840621-1839677 (Counterclockwise)

Preceding gene: 225853330

Following gene: 225853323

Centisome position: 86.59

GC content: 62.65

Gene sequence:

>945_bases
ATGCAAACAGCATCCTTCAAGAATGGCACGTTGAAGATCGGCACCAGGGGCAGCAAGCTGGCTCTGGCACAGGCTTACCT
CACGCGCCGCCTTTTGCAGGAGGCTCATGGTTTGCCGGAAGATGCGATTGAAATCCTGCCCATGTCCACCGCAGGCGACC
GCATTCAGGACCGCCCGCTTTCGGAAGTTGGCGGCAAGGGGCTGTTTACGGAGGAAATCGAGCAGGCGCTGAAGGATGGG
CGAATCGATATTGCCGTCCACTCGACCAAGGATATGCCCACCGCCTTGCCAGAGGGGCTTCACCTTTCCGTTTTTCTGGA
GCGTGAGGACCCGCGCGACGCTTTCATCGGGCGCAGCGCAAGGCGTTTCATGGATTTGCCGCAGGGCGCCACCGTTGGCT
CGTCCTCGCTGCGCCGTCAGGCGCTTATTCGCCGTCTTCGCCCGGATATCGAGGTGGTGATGTATCGCGGCAATGTGGAT
ACCCGCCTGCGCAAGCTCGATGCGGGCGAAGTGGATGGCACTTTCCTTGCCTGTGCCGGTTTGCGCCGGCTCGGCCTTGC
CGATGTCATCACCGATGTTCTCGATCCATCCGTTTTCCCGCCTGCGCCGGGGCAGGGCGCAATCGGCATTGAAAGCCGCA
TTGGCGACGAGCGGATCGATGTGCTTCTTGCGCCGCTCGCCCATCGCGAAACGCAAATTGCGCTTGCCTGCGAGCGGGCC
TTTCTCGGCGCTCTCGACGGTTCCTGCCGTACGCCTATTGCCGGTCTTGCAACGGTCGAGGGCGACCGGTTGTCCTTCCG
CGGGATGATCCTGACGCCGGATGGCCGGCAGGCCCATGAAGTGACGGCCGAAGGGGTTGTCTCGGATGCAGCCGCGCTCG
GCACAGATGCGGCAAACCGCGTGCGCGCCATGGCGGGCCCGCATTTCTTTGATGGGTGGCAGTAG

Upstream 100 bases:

>100_bases
TGGCTCATATTGGCGCATGTTCAGCAAAAGTGGAAACCGGTTTTGCCTTTGGACATGCATGAAAACGAATGATGAAACCC
GGTACCATGGACGAGGCAAT

Downstream 100 bases:

>100_bases
CATTGTCGGAGCGGTGAAACCGGATGAAGCGGGTTCTTGTTACACGGCCTGAGCCGGCAGCAGCGCAAACCGCAGCAAAG
CTTCGCGCGGCGGGCTATGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDG
RIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVD
TRLRKLDAGEVDGTFLACAGLRRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAGPHFFDGWQ

Sequences:

>Translated_314_residues
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDG
RIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVD
TRLRKLDAGEVDGTFLACAGLRRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAGPHFFDGWQ
>Mature_314_residues
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDG
RIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVD
TRLRKLDAGEVDGTFLACAGLRRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAGPHFFDGWQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=290, Percent_Identity=38.2758620689655, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI66933009, Length=285, Percent_Identity=38.2456140350877, Blast_Score=181, Evalue=9e-46,
Organism=Escherichia coli, GI48994974, Length=294, Percent_Identity=45.578231292517, Blast_Score=236, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319996, Length=317, Percent_Identity=35.6466876971609, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20130425, Length=266, Percent_Identity=40.9774436090226, Blast_Score=191, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_BRUA1 (B2S842)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935725.1
- ProteinModelPortal:   B2S842
- SMR:   B2S842
- GeneID:   6326869
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I17690
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33838; Mature: 33838

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCHHCCCH
SEVGGKGLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSA
HHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHCHHH
RRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAG
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCHHHHHHH
LRRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
HHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANR
HHHHCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
VRAMAGPHFFDGWQ
HHHHCCCCCCCCCC
>Mature Secondary Structure
MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCHHCCCH
SEVGGKGLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSA
HHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHCHHH
RRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAG
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCHHHHHHH
LRRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERA
HHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
FLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANR
HHHHCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
VRAMAGPHFFDGWQ
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA