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The map label for this gene is hemK [H]

Identifier: 225853307

GI number: 225853307

Start: 1822175

End: 1823062

Strand: Reverse

Name: hemK [H]

Synonym: BMEA_A1922

Alternate gene names: 225853307

Gene position: 1823062-1822175 (Counterclockwise)

Preceding gene: 225853308

Following gene: 225853305

Centisome position: 85.76

GC content: 58.11

Gene sequence:

>888_bases
GTGAGCAGCGAAGAGGTGGAGCGCCTTGACCGGCTGATGGCAGAGGCCCGCGCGAAATTGCGTGCGGCGGGGGGCGAGAC
GCCCGATCTCGATGCGCGTCTGCTCATTGAATGGGCGACGGGTGCGACACGCCTCGATCTTGTTTCCCAGCCGGAAAAGC
TAATCGGCAGCGCCGAGGCTGAAAAGCTGCGGGCGGCGCTGGAACGGCGTGCGGGCGGAGAGCCGGTGCACCGAATCATG
GGCCAGCGTGAATTTTATGGCCTGCCTTTCCGCCTTTCCGCCCAAACGCTGGAGCCGCGGCCGGATACGGAGGCGCTGGT
GGAACTGGTGATTCCCGTCCTTGAGCAGCTCATCGCCAGGCACGGTACGGCCGAGGTGCTGGATATGGGCACCGGCACGG
GTGCGATCATCATTTCGCTTCTGCATCGCTTCGAGCATATGCACGGGATCGGTGTCGATGTGGCCGAGGGAGCGCTTGCC
ACGGCGCGAATCAACGCCATAGACAATGGCGTTGGCGAGAGGTTTGCCGGTTTGAAGAGCGACTGGTTCTCCAATGTCAG
CGGGAAATTTCATCTGATTGTTTCAAATCCGCCTTATATTCCCCATGCTGAGATTGCCGGTTTGTCGCGCGAAGTGCGTG
AGCATGATCCGCTTGCAGCACTTGATGGCGGGCCGGATGGACTTGATTTTTACAAAGCCCTTGCACAAGGAGTGGGTGCG
TATTTATATAAAGACGGGATGGTTGCCGTAGAAATCGGCGCCGGACAATTCCAGGATGTCGAAGCACTGTTCAAAAGCAC
AGGTTTTTCGCTTGCCGGCGAAGCAAATGATCTTGGTGGCCACAGAAGAGCCATGCTTTTCGGGCAGATATCTAATACGC
AATTTTGA

Upstream 100 bases:

>100_bases
ACAAGCTCGACCGCGTGATGGAAGGCGAACTGGACGAACTGGTCGATGCGCTGATTTCCGATCACCAGACCGCCCTTCTG
GCCGAACTGGGCGAGCAGCC

Downstream 100 bases:

>100_bases
TAAGCGCCGACGCTAAAAAACGCTTGGAATTTACTGCGAAGCCGTTTAGTTTCCGGCCACCGTATACAGCCAGAATGGTT
TTGCCCTCGTGAGGGCGGTG

Product: methyltransferase, HemK family protein

Products: NA

Alternate protein names: M.MloHemKP [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSSEEVERLDRLMAEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEAEKLRAALERRAGGEPVHRIM
GQREFYGLPFRLSAQTLEPRPDTEALVELVIPVLEQLIARHGTAEVLDMGTGTGAIIISLLHRFEHMHGIGVDVAEGALA
TARINAIDNGVGERFAGLKSDWFSNVSGKFHLIVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGA
YLYKDGMVAVEIGAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF

Sequences:

>Translated_295_residues
MSSEEVERLDRLMAEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEAEKLRAALERRAGGEPVHRIM
GQREFYGLPFRLSAQTLEPRPDTEALVELVIPVLEQLIARHGTAEVLDMGTGTGAIIISLLHRFEHMHGIGVDVAEGALA
TARINAIDNGVGERFAGLKSDWFSNVSGKFHLIVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGA
YLYKDGMVAVEIGAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF
>Mature_294_residues
SSEEVERLDRLMAEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEAEKLRAALERRAGGEPVHRIMG
QREFYGLPFRLSAQTLEPRPDTEALVELVIPVLEQLIARHGTAEVLDMGTGTGAIIISLLHRFEHMHGIGVDVAEGALAT
ARINAIDNGVGERFAGLKSDWFSNVSGKFHLIVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGAY
LYKDGMVAVEIGAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=256, Percent_Identity=29.6875, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1787463, Length=276, Percent_Identity=35.1449275362319, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082085, Length=214, Percent_Identity=28.9719626168224, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24582226, Length=246, Percent_Identity=27.2357723577236, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 31820; Mature: 31688

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEEVERLDRLMAEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHHCCHHH
EKLRAALERRAGGEPVHRIMGQREFYGLPFRLSAQTLEPRPDTEALVELVIPVLEQLIAR
HHHHHHHHHCCCCCHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
HGTAEVLDMGTGTGAIIISLLHRFEHMHGIGVDVAEGALATARINAIDNGVGERFAGLKS
CCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCHH
DWFSNVSGKFHLIVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGA
HHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHH
YLYKDGMVAVEIGAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF
HHCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEECCCCCC
>Mature Secondary Structure 
SSEEVERLDRLMAEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEA
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHHCCHHH
EKLRAALERRAGGEPVHRIMGQREFYGLPFRLSAQTLEPRPDTEALVELVIPVLEQLIAR
HHHHHHHHHCCCCCHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
HGTAEVLDMGTGTGAIIISLLHRFEHMHGIGVDVAEGALATARINAIDNGVGERFAGLKS
CCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCHH
DWFSNVSGKFHLIVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGA
HHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHH
YLYKDGMVAVEIGAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF
HHCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]