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The map label for this gene is rppH [H]

Identifier: 225853278

GI number: 225853278

Start: 1786011

End: 1786547

Strand: Reverse

Name: rppH [H]

Synonym: BMEA_A1886

Alternate gene names: 225853278

Gene position: 1786547-1786011 (Counterclockwise)

Preceding gene: 225853279

Following gene: 225853277

Centisome position: 84.05

GC content: 60.34

Gene sequence:

>537_bases
ATGTCCGAGCATAAAGGCCCAACCGGCGCGATGGTCGATCCTGAAAGCCTGCCTTACCGTCCCTGTGTCGGGCTGATGGT
TCTCAACAAGGCGGGGCTGGTCTGGGCCGGGCGGCGCATCGTCATTCCGGGCGATGAAATGGATGGCGCCACACAGCTCT
GGCAGATGCCGCAGGGGGGCATCGATAAGGGCGAGGACCCGGCGCAAGCCGCGCTGCGCGAACTTTATGAAGAAACCGGC
ATGACGTCGGTCTCGCTTCTGGAGGAAGCATCGGACTGGATCAATTACGATCTGCCGCCGCATCTGGTGGGGCTGGCGCT
CAAGGGAAAATATCGCGGCCAGACGCAGAAATGGTTCGCCTATCGCTTCGAGGGCGATGAAAGTGAAATTGCGATCAATC
CGCCACCCGGTGGCCACACTGCTGAGTTCGATTGCTGGGAATGGAAGCCGATGGCTGACCTGCCGAACCTGATCGTGCCG
TTCAAGCGCAAGGTCTATGAACAGGTGGTTGCGACTTTCCGGCATCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
TATTGCCTGTAATTTGCCAGATTGCCTGTAATTTGATTGAAGGCGTGAAAGCTGCTGGATATCAATCGAGTGAAATATCC
GCGAATTGATGGAGAGTGGC

Downstream 100 bases:

>100_bases
TTTTCATCGGTCGTGCCTGTCTCCCCCCTTGTGCGGTGGGTCAACATATTGTCAACTCCACCTCAAATCGCTTCGGCCTT
TTTCGCGCGAAGCGTTTTGA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSEHKGPTGAMVDPESLPYRPCVGLMVLNKAGLVWAGRRIVIPGDEMDGATQLWQMPQGGIDKGEDPAQAALRELYEETG
MTSVSLLEEASDWINYDLPPHLVGLALKGKYRGQTQKWFAYRFEGDESEIAINPPPGGHTAEFDCWEWKPMADLPNLIVP
FKRKVYEQVVATFRHLAA

Sequences:

>Translated_178_residues
MSEHKGPTGAMVDPESLPYRPCVGLMVLNKAGLVWAGRRIVIPGDEMDGATQLWQMPQGGIDKGEDPAQAALRELYEETG
MTSVSLLEEASDWINYDLPPHLVGLALKGKYRGQTQKWFAYRFEGDESEIAINPPPGGHTAEFDCWEWKPMADLPNLIVP
FKRKVYEQVVATFRHLAA
>Mature_177_residues
SEHKGPTGAMVDPESLPYRPCVGLMVLNKAGLVWAGRRIVIPGDEMDGATQLWQMPQGGIDKGEDPAQAALRELYEETGM
TSVSLLEEASDWINYDLPPHLVGLALKGKYRGQTQKWFAYRFEGDESEIAINPPPGGHTAEFDCWEWKPMADLPNLIVPF
KRKVYEQVVATFRHLAA

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=165, Percent_Identity=36.3636363636364, Blast_Score=98, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19855; Mature: 19724

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHKGPTGAMVDPESLPYRPCVGLMVLNKAGLVWAGRRIVIPGDEMDGATQLWQMPQGG
CCCCCCCCCCCCCCCCCCCCCHHHEEEECCCCEEEECCEEEECCCCCCCHHHHHHCCCCC
IDKGEDPAQAALRELYEETGMTSVSLLEEASDWINYDLPPHLVGLALKGKYRGQTQKWFA
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCCEEEE
YRFEGDESEIAINPPPGGHTAEFDCWEWKPMADLPNLIVPFKRKVYEQVVATFRHLAA
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEHKGPTGAMVDPESLPYRPCVGLMVLNKAGLVWAGRRIVIPGDEMDGATQLWQMPQGG
CCCCCCCCCCCCCCCCCCCCHHHEEEECCCCEEEECCEEEECCCCCCCHHHHHHCCCCC
IDKGEDPAQAALRELYEETGMTSVSLLEEASDWINYDLPPHLVGLALKGKYRGQTQKWFA
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCCEEEE
YRFEGDESEIAINPPPGGHTAEFDCWEWKPMADLPNLIVPFKRKVYEQVVATFRHLAA
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA