Click here to switch to the map view.

The map label for this gene is pyc [H]

Identifier: 225853228

GI number: 225853228

Start: 1728498

End: 1731974

Strand: Reverse

Name: pyc [H]

Synonym: BMEA_A1831

Alternate gene names: 225853228

Gene position: 1731974-1728498 (Counterclockwise)

Preceding gene: 225853229

Following gene: 225853227

Centisome position: 81.48

GC content: 58.73

Gene sequence:

>3477_bases
TTGTCTTTCGCTCCAAAGCCTATCTCGAAAATTCTGGTCGCCAACCGATCTGAAATCGCAATTCGCGTATTCCGCGCCGC
CAATGAGCTGGGGCTCAAAACGGTGACCATATGGGCTGAGGAAGACAAGCTTTCCCTGCATCGCTTCAAGGCGGATGAAA
GCTATCAGGTCGGTCGCGGACCGCATCTGGATCGCGATCTTGGCCCCATTGAAAGCTATCTTTCCATTGACGAAATCATC
CGCGTTGCCAAGCTTTCGGGCGCCGATGCGATCCATCCAGGTTACGGTCTCCTGTCGGAAAGCCCGGAATTTGCCGAAGC
CTGCGCGGAAAACGGTATCGTCTTCATCGGGCCGAAGCCGGAAACCATGCGCCGCCTCGGCAACAAGGTCGCCGCGCGCA
ATCTCGCTATCGAGATTGGCGTGCCGGTGGTGCCTGCCACCGATCCGCTGCCGGATGATATGGATGAGGTGAAGAAGCTT
GCCGCCCAGATCGGCTATCCGCTGATGCTGAAAGCAAGCTGGGGCGGCGGCGGCCGCGGTATGCGCGCCATCCGGGCTGA
AGCCGATCTTGCCCGCGAGGTGATGGAAGCCAAGCGCGAGGCCAAGGCGGCCTTTGGCAAGGATGAAGTTTATCTCGAAA
AGCTGGTGGAGCGTGCCCGCCATGTCGAAGTGCAGATATTGGGCGATACGTACGGCAATGCGGTCCATCTTTTTGAGCGT
GACTGCTCCATCCAGCGCCGTAACCAGAAGGTCGTGGAGCGCGCGCCTGCACCCTATCTCAACGATGCGCAGCGCCGCGA
GCTGGCCGATTATGGCCTGAAGATCGCGCATGCCACCGATTATATCGGTGCTGGCACGGTTGAGTTCCTCATGGATGCCG
ATACCGGCAAGTTCTATTTCATCGAGGTCAATCCACGCATTCAGGTGGAGCATACGGTCACGGAAGAAGTGACCGGCATC
GATATCGTCAAGGCGCAGATCCATATTCTGGAAGGCTTTGCCATCGGCACGCCGGAATCGGGCGTGCCGCGCCAGGAGGA
TATCCGCCTCAATGGCCACGCGCTGCAATGCCGCATCACAACGGAAGACCCGGAACAGAATTTCATCCCCGATTACGGGC
GCATTCAGGCCTATCGTTCGGCGGCGGGCTTCGGCATCCGTCTCGATGGCGGCACGGCCTATTCGGGCGCATTCATCACC
CGTTATTACGACCCGCTTCTGGTAAAGGTGACGGCATCCGGCGCGACGCCGCTTGAAGCCATTCACCGCATGGACCGCGC
CTTGCGCGAGTTCCGCATTCGCGGCGTGGCAACGAACCTCACCTTCCTCGAAGCGATCATCAATCATCCGAAATTCCAGT
CGAACGATTATACGACCCGTTTCATCGATACGACGCCGGAATTGTTCGAGCAGATGAAGCGGCAGGATCGCGCCACCAAG
CTTTTGACCTATATTGCCGATGTGACCGTCAACGGCCATCCCGAAACCAAGGGCCGCGCGAAACCCGCCAGGGATGCTGC
CAAGCCGCGCGTGCCGTGGTTTGGCGACAAGCTGGTCGCTGACGGCACCAAACAGCTTCTGGACCAGCTTGGGCCGAAGA
AGTTTGCCGAATGGATGCGCAATGAAAAGCGCGCGCTGATTACTGATACCACCATGCGCGATGGCCACCAGTCATTGCTT
GCCACGCGCGTGCGCACCTATGATATTGCGCGGATCGCCAATGCTTACGCGCAGGCGCTGCCAAACCTGTTCTCGCTGGA
ATGCTGGGGCGGGGCTACTTTCGACGTCTCCATGCGCTTCCTGACCGAAGACCCGTGGGAGCGTCTGGCACTGGTGCGCG
AAGGCGCGCCCAACCTCCTGTTGCAGATGCTTCTGCGCGGTGCGAACGGGGTTGGCTACAAATCCTATCCGGACAATGTG
GTGAAATATTTCGTGCGCGAGGCAGCGCGCGCGGGCATTGACCTGTTCCGCGTTTTCGACAGCCTCAACTGGGTTGAGAA
CATGCGCGTGTCGATGGATGCGGTGCTGGAGGAAAACAAGCTCTGTGAAGCGGCGATCTGCTATACGGGCGATATTTTGA
ACCCGGATCGCGCCAAATACGACCTTAATTATTACGTCAATCTGGCGAAGGAAGTGGAAAAGGCTGGCGCGCATATTATT
GCGGTCAAGGATATGGCGGGCTTGCTGAAGCCTGCCGCCGCGCGCGTGCTGTTCAAGGCGCTGCGCGAGGAAACCGATCT
GCCGATCCATTTCCACACACATGATACGTCGGGCATTTCGGCGGCGACCGTGCTTGCTGCAATCGATGCGGGCGTGGATG
TCGTGGATGCAGCGATGGACGCACTTTCGGGCAATACATCGCAGCCCTGCCTCGGTTCCATCGTTGAAGCGCTGCATGGT
TCCGAGCGTGATTCGGGGCTCGACCCGGATTTGATCCGCCGTATTTCCTTTTATTGGGAAGCGGTGCGCCATCAATATGC
AGCTTTTGAAAGCGACCTCAAGGGACCGGCTTCGGAAGTCTATCTTCACGAAATGCCGGGTGGCCAGTTCACCAATCTGA
AGGAACAGGCGCGCTCGCTGGGGCTTGAAACGCGCTGGCATGAAGTGGCGCAGGCCTATGCCGATGTGAACCGCATGTTC
GGCGATATCGTCAAGGTCACGCCATCCTCCAAGGTGGTGGGCGACATGGCGCTGATGATGGTTGCCCAAGACCTCACCGT
TGCCGATGTCGAGAACCCTGCCAAGGATATTGCCTTCCCGGATTCGGTGGTTTCCATGATGCGTGGCGATCTCGGCCAGC
CGCCATCCGGCTGGCCGGAAGCCTTGCAGAAAAAGGTTCTGAAAGGTGAAAAGCCTTTCACCGTGCGCCCCGGCTCGCTT
CTGCCTGCCGCCGATCTCGATGCGGAACGCAAGAGCTTTGAGGACAGTGTCGGCCGCAAGCTTTCCGATCAGGAATTTGC
TTCGGCGCTGATGTATCCGAAGGTCTTCACCGATTATGCTACGGCGCATGAAACCTATGGTCCGACGAGCGTGCTGCCGA
CGCCGGTTTATTTCTACGGCCTCAAGCCGGAAGAAGAAGTTTTTGTCGATCTGGAGCGTGGAAAGACGCTGGTGATCGTC
AATCAGGCTATGAGCGAGACCGACGAGAAGGGCATGGTGACGGTGTTCTTCGAGCTGAACGGCCAGCCGCGCCGCATCAA
GGTGCCAAACCGTGCCAAGAGTGCTTCCGGTGGTGTCCGCCGCAAGGTGGAGGCGGGCAATGACAAACAGGTCGGTGCGC
CAATGCCGGGCGTTATCTCCACCGTTGCGGTTGTGGCAGGCCAGAAGGTTACGCAGGGCGACGTGCTTCTATCCATCGAG
GCGATGAAGATGGAAACCGCCATCCATGCCGAACGCGATGGCACTATCGCGGAAGTGCTGGTCCGCCCCGGCGAGCAGAT
CGACGCGAAGGATTTGCTCATCGTTTACGCCGAGTAA

Upstream 100 bases:

>100_bases
AAACGGAATCGTTGGAACCGTTCTATTTCTTTGTTTTTACGCATTATCTGACGCAAAACCGCTTCGCATTTTTGCTGGAA
ATGCACTAGGGAGATCTGCC

Downstream 100 bases:

>100_bases
GTCTGTGCGGCGGCGGGTATGAAGGTTTTACGGGCGGCAGCGGACCGCAACTGAGGGATAGATGGTACAGGTTTCCGGAC
GCGCAGATATGGCGCCTGCG

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1158; Mature: 1157

Protein sequence:

>1158_residues
MSFAPKPISKILVANRSEIAIRVFRAANELGLKTVTIWAEEDKLSLHRFKADESYQVGRGPHLDRDLGPIESYLSIDEII
RVAKLSGADAIHPGYGLLSESPEFAEACAENGIVFIGPKPETMRRLGNKVAARNLAIEIGVPVVPATDPLPDDMDEVKKL
AAQIGYPLMLKASWGGGGRGMRAIRAEADLAREVMEAKREAKAAFGKDEVYLEKLVERARHVEVQILGDTYGNAVHLFER
DCSIQRRNQKVVERAPAPYLNDAQRRELADYGLKIAHATDYIGAGTVEFLMDADTGKFYFIEVNPRIQVEHTVTEEVTGI
DIVKAQIHILEGFAIGTPESGVPRQEDIRLNGHALQCRITTEDPEQNFIPDYGRIQAYRSAAGFGIRLDGGTAYSGAFIT
RYYDPLLVKVTASGATPLEAIHRMDRALREFRIRGVATNLTFLEAIINHPKFQSNDYTTRFIDTTPELFEQMKRQDRATK
LLTYIADVTVNGHPETKGRAKPARDAAKPRVPWFGDKLVADGTKQLLDQLGPKKFAEWMRNEKRALITDTTMRDGHQSLL
ATRVRTYDIARIANAYAQALPNLFSLECWGGATFDVSMRFLTEDPWERLALVREGAPNLLLQMLLRGANGVGYKSYPDNV
VKYFVREAARAGIDLFRVFDSLNWVENMRVSMDAVLEENKLCEAAICYTGDILNPDRAKYDLNYYVNLAKEVEKAGAHII
AVKDMAGLLKPAAARVLFKALREETDLPIHFHTHDTSGISAATVLAAIDAGVDVVDAAMDALSGNTSQPCLGSIVEALHG
SERDSGLDPDLIRRISFYWEAVRHQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADVNRMF
GDIVKVTPSSKVVGDMALMMVAQDLTVADVENPAKDIAFPDSVVSMMRGDLGQPPSGWPEALQKKVLKGEKPFTVRPGSL
LPAADLDAERKSFEDSVGRKLSDQEFASALMYPKVFTDYATAHETYGPTSVLPTPVYFYGLKPEEEVFVDLERGKTLVIV
NQAMSETDEKGMVTVFFELNGQPRRIKVPNRAKSASGGVRRKVEAGNDKQVGAPMPGVISTVAVVAGQKVTQGDVLLSIE
AMKMETAIHAERDGTIAEVLVRPGEQIDAKDLLIVYAE

Sequences:

>Translated_1158_residues
MSFAPKPISKILVANRSEIAIRVFRAANELGLKTVTIWAEEDKLSLHRFKADESYQVGRGPHLDRDLGPIESYLSIDEII
RVAKLSGADAIHPGYGLLSESPEFAEACAENGIVFIGPKPETMRRLGNKVAARNLAIEIGVPVVPATDPLPDDMDEVKKL
AAQIGYPLMLKASWGGGGRGMRAIRAEADLAREVMEAKREAKAAFGKDEVYLEKLVERARHVEVQILGDTYGNAVHLFER
DCSIQRRNQKVVERAPAPYLNDAQRRELADYGLKIAHATDYIGAGTVEFLMDADTGKFYFIEVNPRIQVEHTVTEEVTGI
DIVKAQIHILEGFAIGTPESGVPRQEDIRLNGHALQCRITTEDPEQNFIPDYGRIQAYRSAAGFGIRLDGGTAYSGAFIT
RYYDPLLVKVTASGATPLEAIHRMDRALREFRIRGVATNLTFLEAIINHPKFQSNDYTTRFIDTTPELFEQMKRQDRATK
LLTYIADVTVNGHPETKGRAKPARDAAKPRVPWFGDKLVADGTKQLLDQLGPKKFAEWMRNEKRALITDTTMRDGHQSLL
ATRVRTYDIARIANAYAQALPNLFSLECWGGATFDVSMRFLTEDPWERLALVREGAPNLLLQMLLRGANGVGYKSYPDNV
VKYFVREAARAGIDLFRVFDSLNWVENMRVSMDAVLEENKLCEAAICYTGDILNPDRAKYDLNYYVNLAKEVEKAGAHII
AVKDMAGLLKPAAARVLFKALREETDLPIHFHTHDTSGISAATVLAAIDAGVDVVDAAMDALSGNTSQPCLGSIVEALHG
SERDSGLDPDLIRRISFYWEAVRHQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADVNRMF
GDIVKVTPSSKVVGDMALMMVAQDLTVADVENPAKDIAFPDSVVSMMRGDLGQPPSGWPEALQKKVLKGEKPFTVRPGSL
LPAADLDAERKSFEDSVGRKLSDQEFASALMYPKVFTDYATAHETYGPTSVLPTPVYFYGLKPEEEVFVDLERGKTLVIV
NQAMSETDEKGMVTVFFELNGQPRRIKVPNRAKSASGGVRRKVEAGNDKQVGAPMPGVISTVAVVAGQKVTQGDVLLSIE
AMKMETAIHAERDGTIAEVLVRPGEQIDAKDLLIVYAE
>Mature_1157_residues
SFAPKPISKILVANRSEIAIRVFRAANELGLKTVTIWAEEDKLSLHRFKADESYQVGRGPHLDRDLGPIESYLSIDEIIR
VAKLSGADAIHPGYGLLSESPEFAEACAENGIVFIGPKPETMRRLGNKVAARNLAIEIGVPVVPATDPLPDDMDEVKKLA
AQIGYPLMLKASWGGGGRGMRAIRAEADLAREVMEAKREAKAAFGKDEVYLEKLVERARHVEVQILGDTYGNAVHLFERD
CSIQRRNQKVVERAPAPYLNDAQRRELADYGLKIAHATDYIGAGTVEFLMDADTGKFYFIEVNPRIQVEHTVTEEVTGID
IVKAQIHILEGFAIGTPESGVPRQEDIRLNGHALQCRITTEDPEQNFIPDYGRIQAYRSAAGFGIRLDGGTAYSGAFITR
YYDPLLVKVTASGATPLEAIHRMDRALREFRIRGVATNLTFLEAIINHPKFQSNDYTTRFIDTTPELFEQMKRQDRATKL
LTYIADVTVNGHPETKGRAKPARDAAKPRVPWFGDKLVADGTKQLLDQLGPKKFAEWMRNEKRALITDTTMRDGHQSLLA
TRVRTYDIARIANAYAQALPNLFSLECWGGATFDVSMRFLTEDPWERLALVREGAPNLLLQMLLRGANGVGYKSYPDNVV
KYFVREAARAGIDLFRVFDSLNWVENMRVSMDAVLEENKLCEAAICYTGDILNPDRAKYDLNYYVNLAKEVEKAGAHIIA
VKDMAGLLKPAAARVLFKALREETDLPIHFHTHDTSGISAATVLAAIDAGVDVVDAAMDALSGNTSQPCLGSIVEALHGS
ERDSGLDPDLIRRISFYWEAVRHQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADVNRMFG
DIVKVTPSSKVVGDMALMMVAQDLTVADVENPAKDIAFPDSVVSMMRGDLGQPPSGWPEALQKKVLKGEKPFTVRPGSLL
PAADLDAERKSFEDSVGRKLSDQEFASALMYPKVFTDYATAHETYGPTSVLPTPVYFYGLKPEEEVFVDLERGKTLVIVN
QAMSETDEKGMVTVFFELNGQPRRIKVPNRAKSASGGVRRKVEAGNDKQVGAPMPGVISTVAVVAGQKVTQGDVLLSIEA
MKMETAIHAERDGTIAEVLVRPGEQIDAKDLLIVYAE

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1152, Percent_Identity=48.8715277777778, Blast_Score=1056, Evalue=0.0,
Organism=Homo sapiens, GI106049295, Length=1152, Percent_Identity=48.8715277777778, Blast_Score=1056, Evalue=0.0,
Organism=Homo sapiens, GI106049292, Length=1152, Percent_Identity=48.8715277777778, Blast_Score=1056, Evalue=0.0,
Organism=Homo sapiens, GI116805327, Length=466, Percent_Identity=43.3476394849785, Blast_Score=385, Evalue=1e-106,
Organism=Homo sapiens, GI65506442, Length=489, Percent_Identity=40.4907975460123, Blast_Score=352, Evalue=1e-96,
Organism=Homo sapiens, GI189095269, Length=489, Percent_Identity=40.4907975460123, Blast_Score=352, Evalue=2e-96,
Organism=Homo sapiens, GI295821183, Length=489, Percent_Identity=40.4907975460123, Blast_Score=352, Evalue=2e-96,
Organism=Homo sapiens, GI134142062, Length=524, Percent_Identity=32.6335877862595, Blast_Score=237, Evalue=4e-62,
Organism=Homo sapiens, GI38679960, Length=574, Percent_Identity=30.4878048780488, Blast_Score=233, Evalue=7e-61,
Organism=Homo sapiens, GI38679977, Length=574, Percent_Identity=30.4878048780488, Blast_Score=233, Evalue=8e-61,
Organism=Homo sapiens, GI38679967, Length=574, Percent_Identity=30.4878048780488, Blast_Score=233, Evalue=8e-61,
Organism=Homo sapiens, GI38679971, Length=574, Percent_Identity=30.4878048780488, Blast_Score=233, Evalue=9e-61,
Organism=Homo sapiens, GI38679974, Length=574, Percent_Identity=30.4878048780488, Blast_Score=233, Evalue=9e-61,
Organism=Homo sapiens, GI18105007, Length=325, Percent_Identity=20.9230769230769, Blast_Score=68, Evalue=5e-11,
Organism=Escherichia coli, GI1789654, Length=465, Percent_Identity=45.3763440860215, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562816, Length=1161, Percent_Identity=49.7846683893196, Blast_Score=1064, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71987519, Length=474, Percent_Identity=43.6708860759494, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567343, Length=464, Percent_Identity=39.8706896551724, Blast_Score=327, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI133931226, Length=507, Percent_Identity=29.9802761341223, Blast_Score=207, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=523, Percent_Identity=29.0630975143403, Blast_Score=206, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=523, Percent_Identity=29.0630975143403, Blast_Score=205, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1163, Percent_Identity=46.6895958727429, Blast_Score=1038, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1160, Percent_Identity=47.1551724137931, Blast_Score=1020, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319685, Length=465, Percent_Identity=36.5591397849462, Blast_Score=310, Evalue=9e-85,
Organism=Saccharomyces cerevisiae, GI6324343, Length=527, Percent_Identity=30.3605313092979, Blast_Score=221, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6323863, Length=437, Percent_Identity=32.7231121281465, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24652212, Length=1157, Percent_Identity=48.0553154710458, Blast_Score=1045, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652210, Length=1157, Percent_Identity=48.0553154710458, Blast_Score=1045, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652214, Length=1157, Percent_Identity=48.0553154710458, Blast_Score=1045, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921944, Length=1157, Percent_Identity=48.0553154710458, Blast_Score=1045, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652216, Length=1157, Percent_Identity=48.0553154710458, Blast_Score=1045, Evalue=0.0,
Organism=Drosophila melanogaster, GI281363050, Length=1173, Percent_Identity=47.5703324808184, Blast_Score=1041, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652224, Length=1173, Percent_Identity=47.5703324808184, Blast_Score=1041, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652222, Length=1173, Percent_Identity=47.5703324808184, Blast_Score=1041, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652220, Length=1173, Percent_Identity=47.5703324808184, Blast_Score=1041, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652218, Length=1173, Percent_Identity=47.5703324808184, Blast_Score=1041, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651757, Length=461, Percent_Identity=42.0824295010846, Blast_Score=360, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24651759, Length=421, Percent_Identity=41.0926365795724, Blast_Score=315, Evalue=1e-85,
Organism=Drosophila melanogaster, GI161076409, Length=518, Percent_Identity=30.3088803088803, Blast_Score=208, Evalue=1e-53,
Organism=Drosophila melanogaster, GI161076407, Length=518, Percent_Identity=30.3088803088803, Blast_Score=208, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24586460, Length=518, Percent_Identity=30.3088803088803, Blast_Score=208, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24586458, Length=518, Percent_Identity=30.3088803088803, Blast_Score=208, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 127927; Mature: 127796

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFAPKPISKILVANRSEIAIRVFRAANELGLKTVTIWAEEDKLSLHRFKADESYQVGRG
CCCCCCCHHHHHHCCCCHHEEHEEHHHHHCCCEEEEEEECCCCCCHHEECCCCCCCCCCC
PHLDRDLGPIESYLSIDEIIRVAKLSGADAIHPGYGLLSESPEFAEACAENGIVFIGPKP
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCC
ETMRRLGNKVAARNLAIEIGVPVVPATDPLPDDMDEVKKLAAQIGYPLMLKASWGGGGRG
HHHHHHHHHHHHCCEEEEECCCEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
MRAIRAEADLAREVMEAKREAKAAFGKDEVYLEKLVERARHVEVQILGDTYGNAVHLFER
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEEECCCCCCEEEEEHH
DCSIQRRNQKVVERAPAPYLNDAQRRELADYGLKIAHATDYIGAGTVEFLMDADTGKFYF
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCEEEEECCCCCCCCCEEEEEECCCCEEEE
IEVNPRIQVEHTVTEEVTGIDIVKAQIHILEGFAIGTPESGVPRQEDIRLNGHALQCRIT
EEECCEEEEEEEHHHHHCCCEEEEEEEEEEECEEECCCCCCCCCCCCEEECCEEEEEEEE
TEDPEQNFIPDYGRIQAYRSAAGFGIRLDGGTAYSGAFITRYYDPLLVKVTASGATPLEA
CCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEECCEEHEEECCCEEEEEECCCCCHHHH
IHRMDRALREFRIRGVATNLTFLEAIINHPKFQSNDYTTRFIDTTPELFEQMKRQDRATK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHH
LLTYIADVTVNGHPETKGRAKPARDAAKPRVPWFGDKLVADGTKQLLDQLGPKKFAEWMR
HHHHHHHEEECCCCCCCCCCCCCHHCCCCCCCCCCCHHHHCHHHHHHHHCCHHHHHHHHH
NEKRALITDTTMRDGHQSLLATRVRTYDIARIANAYAQALPNLFSLECWGGATFDVSMRF
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEE
LTEDPWERLALVREGAPNLLLQMLLRGANGVGYKSYPDNVVKYFVREAARAGIDLFRVFD
CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
SLNWVENMRVSMDAVLEENKLCEAAICYTGDILNPDRAKYDLNYYVNLAKEVEKAGAHII
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCEEE
AVKDMAGLLKPAAARVLFKALREETDLPIHFHTHDTSGISAATVLAAIDAGVDVVDAAMD
EEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHH
ALSGNTSQPCLGSIVEALHGSERDSGLDPDLIRRISFYWEAVRHQYAAFESDLKGPASEV
HHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHE
YLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADVNRMFGDIVKVTPSSKVVGDMALMM
EEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
VAQDLTVADVENPAKDIAFPDSVVSMMRGDLGQPPSGWPEALQKKVLKGEKPFTVRPGSL
HHHCCEEECCCCCHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCC
LPAADLDAERKSFEDSVGRKLSDQEFASALMYPKVFTDYATAHETYGPTSVLPTPVYFYG
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
LKPEEEVFVDLERGKTLVIVNQAMSETDEKGMVTVFFELNGQPRRIKVPNRAKSASGGVR
CCCCHHEEEEECCCCEEEEEECHHCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCE
RKVEAGNDKQVGAPMPGVISTVAVVAGQKVTQGDVLLSIEAMKMETAIHAERDGTIAEVL
EEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHCCCCCCHHHHH
VRPGEQIDAKDLLIVYAE
HCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SFAPKPISKILVANRSEIAIRVFRAANELGLKTVTIWAEEDKLSLHRFKADESYQVGRG
CCCCCCHHHHHHCCCCHHEEHEEHHHHHCCCEEEEEEECCCCCCHHEECCCCCCCCCCC
PHLDRDLGPIESYLSIDEIIRVAKLSGADAIHPGYGLLSESPEFAEACAENGIVFIGPKP
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCC
ETMRRLGNKVAARNLAIEIGVPVVPATDPLPDDMDEVKKLAAQIGYPLMLKASWGGGGRG
HHHHHHHHHHHHCCEEEEECCCEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCC
MRAIRAEADLAREVMEAKREAKAAFGKDEVYLEKLVERARHVEVQILGDTYGNAVHLFER
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEEECCCCCCEEEEEHH
DCSIQRRNQKVVERAPAPYLNDAQRRELADYGLKIAHATDYIGAGTVEFLMDADTGKFYF
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCEEEEECCCCCCCCCEEEEEECCCCEEEE
IEVNPRIQVEHTVTEEVTGIDIVKAQIHILEGFAIGTPESGVPRQEDIRLNGHALQCRIT
EEECCEEEEEEEHHHHHCCCEEEEEEEEEEECEEECCCCCCCCCCCCEEECCEEEEEEEE
TEDPEQNFIPDYGRIQAYRSAAGFGIRLDGGTAYSGAFITRYYDPLLVKVTASGATPLEA
CCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEECCEEHEEECCCEEEEEECCCCCHHHH
IHRMDRALREFRIRGVATNLTFLEAIINHPKFQSNDYTTRFIDTTPELFEQMKRQDRATK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHH
LLTYIADVTVNGHPETKGRAKPARDAAKPRVPWFGDKLVADGTKQLLDQLGPKKFAEWMR
HHHHHHHEEECCCCCCCCCCCCCHHCCCCCCCCCCCHHHHCHHHHHHHHCCHHHHHHHHH
NEKRALITDTTMRDGHQSLLATRVRTYDIARIANAYAQALPNLFSLECWGGATFDVSMRF
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEE
LTEDPWERLALVREGAPNLLLQMLLRGANGVGYKSYPDNVVKYFVREAARAGIDLFRVFD
CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
SLNWVENMRVSMDAVLEENKLCEAAICYTGDILNPDRAKYDLNYYVNLAKEVEKAGAHII
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCEEE
AVKDMAGLLKPAAARVLFKALREETDLPIHFHTHDTSGISAATVLAAIDAGVDVVDAAMD
EEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHH
ALSGNTSQPCLGSIVEALHGSERDSGLDPDLIRRISFYWEAVRHQYAAFESDLKGPASEV
HHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHE
YLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADVNRMFGDIVKVTPSSKVVGDMALMM
EEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
VAQDLTVADVENPAKDIAFPDSVVSMMRGDLGQPPSGWPEALQKKVLKGEKPFTVRPGSL
HHHCCEEECCCCCHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCC
LPAADLDAERKSFEDSVGRKLSDQEFASALMYPKVFTDYATAHETYGPTSVLPTPVYFYG
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
LKPEEEVFVDLERGKTLVIVNQAMSETDEKGMVTVFFELNGQPRRIKVPNRAKSASGGVR
CCCCHHEEEEECCCCEEEEEECHHCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCE
RKVEAGNDKQVGAPMPGVISTVAVVAGQKVTQGDVLLSIEAMKMETAIHAERDGTIAEVL
EEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHCCCCCCHHHHH
VRPGEQIDAKDLLIVYAE
HCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]